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TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  7.30E+6nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM103302(SCH772984 | US8546404, 6)
Affinity DataKd:  233nMpH: 7.5 T: 2°CAssay Description:For ERK1 and ERK2, the buffer contained 20 mM HEPES (pH 7.5), 150 mM NaCl and 0.5 mM TCEP. For haspin, the buffer contained 20 mM HEPES (pH 7.5), 250...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2014
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM103302(SCH772984 | US8546404, 6)
Affinity DataKd:  300nMpH: 7.5 T: 2°CAssay Description:For ERK1 and ERK2, the buffer contained 20 mM HEPES (pH 7.5), 150 mM NaCl and 0.5 mM TCEP. For haspin, the buffer contained 20 mM HEPES (pH 7.5), 250...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2014
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM275430(1-[7-(hydroxymethyl)-1- (tetrahydro-2H-pyran-4-ylm...)
Affinity DataAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for full-length ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50271389(CHEMBL4127417)
Affinity DataKd: >1.00E+6nMAssay Description:Binding affinity to ATP-binding site of ERK2 (unknown origin) by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataKd:  0.0501nMAssay Description:Binding affinity to non-phosphorylated biotinylated ERK2 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50169956(2-(Benzooxazol-2-ylsulfanyl)-N-(4-tetrazol-1-yl-ph...)
Affinity DataKd:  5.00E+3nMAssay Description:Dissociation constant for ERK2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50132260(CHEMBL105442 | US8575391, 341 | CI-1040 | 2-(2-chl...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50169957(N-[4-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-thiazol-2...)
Affinity DataKd:  1.60E+4nMAssay Description:Dissociation constant for ERK2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50271374(CHEMBL4127139)
Affinity DataKd: >1.00E+6nMAssay Description:Binding affinity to ATP-binding site of ERK2 (unknown origin) by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM5931(cid_3025986 | CHEMBL296468 | N-(5-{[(5-tert-butyl-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for full-length ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50271376(CHEMBL4127157)
Affinity DataKd:  4.95E+5nMAssay Description:Binding affinity to ATP-binding site of ERK2 (unknown origin) by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM15244(cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50505988(CHEMBL4482864)
Affinity DataKd:  0.0501nMAssay Description:Binding affinity to MEK-activated phosphorylated biotinylated ERK2 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM26300(cid_16007391 | 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)a...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM13531(4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for full-length ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50265959(CHEMBL4071576)
Affinity DataKd:  0.794nMAssay Description:Binding affinity to non-phosphorylated biotinylated ERK2 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM24773(N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for full-length ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50254739(CHEMBL4079223)
Affinity DataKd:  16nMAssay Description:Binding affinity to full length wild type human ERK2 (M1 to P379 residues) expressed in bacterial expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50195448(1-(4-bromophenyl)-2-(5-(furan-2-yl)-4H-1,2,4-triaz...)
Affinity DataKd:  4.50E+4nMAssay Description:Binding affinity to ERK2 by fluorescence quenchingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM32362(cid_11617559 | GW-2580 | 5-[[3-methoxy-4-[(4-metho...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for full-length ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for full-length ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM13535(N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for full-length ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50127014(CHEMBL3628248)
Affinity DataKd:  9.70E+4nMAssay Description:Binding affinity to ERK2 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM13336(4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for full-length ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM13336(4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50271372(CHEMBL4128128)
Affinity DataKd: >1.00E+6nMAssay Description:Binding affinity to ATP-binding site of ERK2 (unknown origin) by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM60665(US9145414, R406 | US9212178, R406 | BDBM50249542)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50355495(CHEMBL1908391)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for full-length ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50309910(N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50254740(CHEMBL4104378)
Affinity DataKd:  500nMAssay Description:Binding affinity to C-terminal FLAG-tagged human ERK2 expressed in Escherichia coli (DE3) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM25084(JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for full-length ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM12621(2,4-Diamino-5-ketopyrimidine 39 | 5-[(2,3-difluoro...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM5931(cid_3025986 | CHEMBL296468 | N-(5-{[(5-tert-butyl-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for full-length ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50271383(CHEMBL4126554)
Affinity DataKd: >1.00E+6nMAssay Description:Binding affinity to ATP-binding site of ERK2 (unknown origin) by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM26474(GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for full-length ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM120095(US8697715, 39 | US9259470, 39 | US10525036, Exampl...)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to MEK-activated phosphorylated biotinylated ERK2 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31088(1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for full-length ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for full-length ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
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