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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataEC50:  500nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50010981(4-(3-Butoxy-4-methoxy-benzyl)-imidazolidin-2-one |...)
Affinity DataEC50:  3.30E+3nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50085135(4-(8-(3-nitrophenyl)-1,7-naphthyridin-6-yl)benzoic...)
Affinity DataEC50:  20nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50393510(CHEMBL1232082)
Affinity DataEC50:  17nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50108504(4-(8-(benzo[c][1,2,5]oxadiazol-5-yl)-1,7-naphthyri...)
Affinity DataEC50:  250nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50040348(BRL-61063 | 8-Amino-1,3-bis-cyclopropylmethyl-3,7-...)
Affinity DataEC50:  910nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50393515(CHEMBL2158061)
Affinity DataEC50:  500nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50393517(CHEMBL2158063)
Affinity DataEC50:  2.10E+3nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50393521(CHEMBL2158067)
Affinity DataEC50:  5.60E+3nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50393523(CHEMBL2158068)
Affinity DataEC50:  4.60E+3nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50240404(CHEMBL19449 | (Ibudilast)1-(2-Isopropyl-pyrazolo[1...)
Affinity DataEC50:  900nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50393511(CHEMBL2158056)
Affinity DataEC50:  15nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50393512(CHEMBL2158057)
Affinity DataEC50:  270nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50042056((R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolid...)
Affinity DataEC50:  3.40E+3nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50042058((4R)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrroli...)
Affinity DataEC50:  480nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50393509(PYRIDOPYRIDAZINONE)
Affinity DataEC50:  220nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50228245(LY-186126 | CHEMBL34945)
Affinity DataKd:  3.90nMAssay Description:Binding affinity for sarcoplasmic reticulum phosphodiesterase 4 of canine ventricleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2019
Entry Details Article
PubMed
LigandPNGBDBM50228245(LY-186126 | CHEMBL34945)
Affinity DataKd:  4.10nMAssay Description:Binding affinity for Phosphodiesterase 4 of canine myocardial vesiclesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2019
Entry Details Article
PubMed
LigandPNGBDBM50471841(CHEMBL334988)
Affinity DataEC50:  7.50E+3nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50223132(CHEMBL30619)
Affinity DataEC50:  3.50E+3nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50471846(CHEMBL434822)
Affinity DataEC50:  2.10E+4nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50223121(CHEMBL281244)
Affinity DataEC50:  1.05E+3nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50223118(CHEMBL31530)
Affinity DataEC50:  600nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50223123(CHEMBL31877)
Affinity DataEC50:  1.80E+4nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50223055(CHEMBL31439)
Affinity DataEC50:  2.10E+3nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50223097(CHEMBL28562)
Affinity DataEC50:  1.70E+3nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50223052(CHEMBL30733)
Affinity DataEC50:  700nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50223129(CHEMBL30379)
Affinity DataEC50:  1.80E+3nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50223187(CHEMBL30966)
Affinity DataEC50:  3.40E+3nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50223189(CHEMBL288545)
Affinity DataEC50:  1.80E+3nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50223120(CHEMBL31063)
Affinity DataEC50:  200nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50223128(CHEMBL31795)
Affinity DataEC50:  2.00E+3nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50415001(GSK-256066 | CHEMBL570015 | GSK-256066 (3))
Affinity DataIC50: 0.00300nMAssay Description:Inhibition of human PDE4 expressed in Saccharomyces cerevisiae preincubated for 30 mins followed by cAMP substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50415001(GSK-256066 | CHEMBL570015 | GSK-256066 (3))
Affinity DataIC50: 0.00300nMAssay Description:Inhibition of human PDE4 expressed in Sf9 cells by non-linear regression analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50495704(Chf-6001 | Chf6001 | J3.309.618F)
Affinity DataIC50: 0.0260nMAssay Description:Inhibition of PDE4 in human U937 cell lysate using cAMP as substrate by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50495709(CHEMBL3113966)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50495735(CHEMBL3113954)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50495736(CHEMBL3113948)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50495750(CHEMBL3113949)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50199701(CHEMBL3968147)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of PDE4 (unknown origin) expressed in Saccharomyces cerevisiae using [3H] cAMP as substrate incubated for 1 hr by scintillation proximity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50495703(CHEMBL3113943)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50495704(Chf-6001 | Chf6001 | J3.309.618F)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50495710(CHEMBL3113976)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50495733(CHEMBL3113962)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50495747(CHEMBL3113968)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50495705(CHEMBL3113964)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50495724(CHEMBL3113950)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50495703(CHEMBL3113943)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50495725(CHEMBL3113946)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50495746(CHEMBL3113953)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
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