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TargetCytochrome P450(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50508661(CHEMBL4524830)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP450More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A7(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50584760(CHEMBL2068968)
Affinity DataIC50: 1.08E+4nMAssay Description:Time dependent inhibition of recombinant human CYP3A7 incubated for 30 mins in presence of NADPH generating system by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A43/3A5/3A7(Human)
Keimyung University

Curated by ChEMBL
LigandPNGBDBM50464556(CHEMBL4289811 | US10464907, Compound 21f | US10889...)
Affinity DataIC50: 2.59E+4nMAssay Description:Inhibition of CYP3A in human pooled human liver microsomes using midazolam as substrate assessed as midazolam 1'-hydroxylation preincubated for 5 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A7 [T409R](Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50088503(CHEMBL3527048)
Affinity DataIC50: 3.30E+4nMAssay Description:Reversible inhibition of midazolam 1'-hydroxylase activity of human recombinant CYP3A7 harboring human P450 oxidoreductase and b5More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A43/3A5/3A7(Human)
Keimyung University

Curated by ChEMBL
LigandPNGBDBM50508419(CHEMBL4471264)
Affinity DataIC50: 3.66E+4nMAssay Description:Inhibition of CYP3A in human liver microsomes assessed as reduction in midazolam 1'-hydroxylation by tandem mass spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A43/3A5/3A7(Human)
Keimyung University

Curated by ChEMBL
LigandPNGBDBM50527104(CHEMBL4447583)
Affinity DataIC50: 6.22E+4nMAssay Description:Inhibition of CYP3A in human liver microsomes using testosterone as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A7(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50584760(CHEMBL2068968)
Affinity DataIC50: 6.48E+4nMAssay Description:Time dependent inhibition of recombinant human CYP3A7 using midazolam as substrate preincubated for 30 mins in presence of NADPH generating system fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A43/3A5/3A7(Human)
Keimyung University

Curated by ChEMBL
LigandPNGBDBM50527104(CHEMBL4447583)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A7(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50584761(BUFALIN | CHEBI:517248 | Bufalin)
Affinity DataIC50: 1.00E+5nMAssay Description:Time dependent inhibition of recombinant human CYP3A7 incubated for 30 mins in presence of NADPH generating system by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A7(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50318484(CHEMBL190461 | 2-((1R,6R)-6-Isopropenyl-3-methyl-c...)
Affinity DataKi:  1.23E+4nMAssay Description:Mixed type inhibition of human recombinant CYP3A7 expressed in baculovirus-infected insect cells using diltiazem as substrate incubated for 30 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed