Compile Data Set for Download or QSAR
Report error Found 76 of affinity data for UniProtKB/TrEMBL: P22199
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398061(CHEMBL2181928)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at rat GAL4-DBD fused MR ligand binding domain transfected in human Huh7 cells co-expressing GAL4-RE-Luc assessed as reduction in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50531569(CHEMBL4532472)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at gal4-fused rat mineralocorticoid receptor LBD in expressed in human U2OS cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM404273(US10017502, Example 6b)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at gal4-fused rat mineralocorticoid receptor LBD in expressed in human U2OS cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398062(CHEMBL2181930)
Affinity DataIC50: 21nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor after 18 hrs by liquid scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398062(CHEMBL2181930)
Affinity DataIC50: 21nMAssay Description:Displacement of [3H]-Aldosterone from MR in rat kidney cytosolic fraction measured after 18 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398060(CHEMBL2181931)
Affinity DataIC50: 22nMAssay Description:Displacement of [3H]Aldosterone C from rat mineralocorticoid receptor by liquid scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50235950(CHEMBL4087750)
Affinity DataIC50: 22nMAssay Description:Displacement of [3H]-Aldosterone from MR in rat renal soluble fraction measured after 18 hrs in presence of glucocorticoid receptor antagonist RU-486...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50235982(CHEMBL4085281)
Affinity DataIC50: 31nMAssay Description:Displacement of [3H]-Aldosterone from MR in rat renal soluble fraction measured after 18 hrs in presence of glucocorticoid receptor antagonist RU-486...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318300(CHEMBL1095097 | SC-66110 | EPLERENONE)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at gal4-fused rat mineralocorticoid receptor LBD in expressed in human U2OS cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM19214([3H]Aldosterone | (1S,2R,10S,11S,14S,15R,17S)-17-h...)
Affinity DataIC50: 43nMAssay Description:Displacement of [3H]Aldo from mineralocorticoid receptor in Sprague-Dawley rat kidney after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM19214([3H]Aldosterone | (1S,2R,10S,11S,14S,15R,17S)-17-h...)
Affinity DataIC50: 43nMAssay Description:Displacement of [3H]aldosterone from Sprague-Dawley rat MR by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50235983(CHEMBL4095450)
Affinity DataIC50: 60nMAssay Description:Displacement of [3H]-Aldosterone from MR in rat renal soluble fraction measured after 18 hrs in presence of glucocorticoid receptor antagonist RU-486...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50235951(CHEMBL4066419)
Affinity DataIC50: 61nMAssay Description:Displacement of [3H]-Aldosterone from MR in rat renal soluble fraction measured after 18 hrs in presence of glucocorticoid receptor antagonist RU-486...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM238159(US9394291, 4a | US10017502, Example 4b)
Affinity DataIC50: 79nMAssay Description:Antagonist activity at gal4-fused rat mineralocorticoid receptor LBD in expressed in human U2OS cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50531586(CHEMBL4462110)
Affinity DataIC50: 79nMAssay Description:Antagonist activity at gal4-fused rat mineralocorticoid receptor LBD in expressed in human U2OS cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50235954(CHEMBL4075017)
Affinity DataIC50: 84nMAssay Description:Displacement of [3H]-Aldosterone from MR in rat renal soluble fraction measured after 18 hrs in presence of glucocorticoid receptor antagonist RU-486...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50531568(CHEMBL4455600)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at gal4-fused rat mineralocorticoid receptor LBD in expressed in human U2OS cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50235952(CHEMBL4079872)
Affinity DataIC50: 100nMAssay Description:Displacement of [3H]-Aldosterone from MR in rat renal soluble fraction measured after 18 hrs in presence of glucocorticoid receptor antagonist RU-486...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50531567(CHEMBL4557032)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at gal4-fused rat mineralocorticoid receptor LBD in expressed in human U2OS cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50235976(CHEMBL4060780)
Affinity DataIC50: 500nMAssay Description:Displacement of [3H]-Aldosterone from MR in Sprague-Dawley rat kidney cytosolic fraction measured after overnight incubation by liquid scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50235978(CHEMBL4064627)
Affinity DataIC50: 500nMAssay Description:Displacement of [3H]-Aldosterone from MR in Sprague-Dawley rat kidney cytosolic fraction measured after overnight incubation by liquid scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50235979(CHEMBL4086138)
Affinity DataIC50: 500nMAssay Description:Displacement of [3H]-Aldosterone from MR in Sprague-Dawley rat kidney cytosolic fraction measured after overnight incubation by liquid scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50235977(CHEMBL4082663)
Affinity DataIC50: 500nMAssay Description:Displacement of [3H]-Aldosterone from MR in Sprague-Dawley rat kidney cytosolic fraction measured after overnight incubation by liquid scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50004519(CHEMBL2181929)
Affinity DataIC50: 500nMAssay Description:Binding affinity to rat mineralocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336275(1-oxo-1,3,4,5,6,7,8,9-octahydrobenzo[c][1]oxacyclo...)
Affinity DataIC50: 580nMAssay Description:Antagonist activity at rat mineralocorticoid receptor-ligand binding domain expressed in AH109 yeast cells co expressing pGADT7-hSRC-1 by two hybrid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336276(1-oxo-1,3,4,5,6,7,8,9,10,11-decahydrobenzo[c][1]ox...)
Affinity DataIC50: 820nMAssay Description:Antagonist activity at rat mineralocorticoid receptor-ligand binding domain expressed in AH109 yeast cells co expressing pGADT7-hSRC-1 by two hybrid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336277(1-oxo-3,4,5,6,7,8,9,10-octahydro-1H-benzo[c][1]oxa...)
Affinity DataIC50: 1.11E+3nMAssay Description:Antagonist activity at rat mineralocorticoid receptor-ligand binding domain expressed in AH109 yeast cells co expressing pGADT7-hSRC-1 by two hybrid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM18161(DHT | Dihydrotestosterone | [3H]DHT | (5alpha,17be...)
Affinity DataIC50: 2.10E+3nMAssay Description:Displacement of [3H]aldosterone from Sprague-Dawley rat MR by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM18161(DHT | Dihydrotestosterone | [3H]DHT | (5alpha,17be...)
Affinity DataIC50: 2.10E+3nMAssay Description:Displacement of [3H]Aldo from mineralocorticoid receptor in Sprague-Dawley rat kidney after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336278((R)-3-methyl-1-oxo-3,4,5,6,7,8,9,10-octahydro-1H-b...)
Affinity DataIC50: 2.78E+3nMAssay Description:Antagonist activity at rat mineralocorticoid receptor-ligand binding domain expressed in AH109 yeast cells co expressing pGADT7-hSRC-1 by two hybrid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336274(1-oxo-3,4,5,6,7,8,9,10,11,12-decahydro-1H-benzo[c]...)
Affinity DataIC50: 2.90E+3nMAssay Description:Antagonist activity at rat mineralocorticoid receptor-ligand binding domain expressed in AH109 yeast cells co expressing pGADT7-hSRC-1 by two hybrid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM19192(BMCL173354 benzo[f]indazole, 6 | (R)-[(4aR,5S)-1-(...)
Affinity DataIC50: 5.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM19191((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 5.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM19199((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 5.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM19200(BMCL173354 benzo[f]indazole, 7 | (S)-[(4aR,5S)-1-(...)
Affinity DataIC50: 5.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM19201((1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4...)
Affinity DataIC50: 5.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM19207((1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4...)
Affinity DataIC50: 5.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338693(2-methyl-2-((3aR,4S,9bS)-8-nitro-3a,4,5,9b-tetrahy...)
Affinity DataIC50: 6.30E+3nMAssay Description:Displacement of [3H]aldosterone from Sprague-Dawley rat MR by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336279((R)-3-methyl-1-oxo-3,4,5,6,7,8,9,10-octahydro-1H-b...)
Affinity DataIC50: 6.51E+3nMAssay Description:Antagonist activity at rat mineralocorticoid receptor-ligand binding domain expressed in AH109 yeast cells co expressing pGADT7-hSRC-1 by two hybrid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167799(1-(4-fluorophenyl)-4a-methyl-4',5'-divinyl-(4'R,4a...)
Affinity DataIC50: 7.40E+3nMAssay Description:Binding affinity for rat mineralocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167808(1-(4-fluorophenyl)-4a-methyl-(4aS)-spiro[4,4a,5,6,...)
Affinity DataIC50: 7.56E+3nMAssay Description:Binding affinity for rat mineralocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336280((R)-de-O-methyllasioplodin | CHEMBL1669749)
Affinity DataIC50: 8.93E+3nMAssay Description:Antagonist activity at rat mineralocorticoid receptor-ligand binding domain expressed in AH109 yeast cells co expressing pGADT7-hSRC-1 by two hybrid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167795(1-(4-fluorophenyl)-4',4a,5'-trimethyl-(4'R,4aS,5'R...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity for rat mineralocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167790(1-(4-fluorophenyl)-4',4a,6'-trimethyl-(4'S,4aS,6'S...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity for rat mineralocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167794(1-(4-fluorophenyl)-4a-methylspiro[1,4,4a,5,6,7-hex...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity for rat mineralocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167796(1-(4-fluorophenyl)-4a-methyl-4',5'-divinyl-(4'R,4a...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity for rat mineralocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50355936(CHEMBL1910411)
Affinity DataIC50: 1.40E+4nMAssay Description:Displacement of [3H]Aldo from mineralocorticoid receptor in Sprague-Dawley rat kidney after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336281((R,Z)-12,14-dimethoxy-3-methyl-3,4,5,6,9,10-hexahy...)
Affinity DataIC50: 1.66E+4nMAssay Description:Antagonist activity at rat mineralocorticoid receptor-ligand binding domain expressed in AH109 yeast cells co expressing pGADT7-hSRC-1 by two hybrid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336282((R)-3-methyl-1-oxo-3,4,5,6,7,8,9,10-octahydro-1H-b...)
Affinity DataIC50: 3.17E+4nMAssay Description:Antagonist activity at rat mineralocorticoid receptor-ligand binding domain expressed in AH109 yeast cells co expressing pGADT7-hSRC-1 by two hybrid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM18525(N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluoro...)
Affinity DataIC50: 3.60E+5nMAssay Description:Displacement of [3H]Aldo from mineralocorticoid receptor in Sprague-Dawley rat kidney after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
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