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TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM39347(MLS000028708 | cid_32798 | SMR000058745 | CLOBETAS...)
Affinity DataKd:  100nMAssay Description:Binding affinity to heme in His-tagged CYP3A5 (unknown origin) expressed in Escherichia coli DH5alpha assessed as changes in absorbance spectra of he...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataKd:  3.10E+3nMAssay Description:Binding affinity to heme in His-tagged CYP3A5 (unknown origin) expressed in Escherichia coli DH5alpha assessed as changes in absorbance spectra of he...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataIC50: 13nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using Midazolam as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM39347(MLS000028708 | cid_32798 | SMR000058745 | CLOBETAS...)
Affinity DataIC50: 21nMAssay Description:Inhibition of CYP3A5 in doxycycline-induced CYP3A5 overexpressing wild type human AsPC1 cells assessed as decrease in 1-hydroxymidazolam formation us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM39347(MLS000028708 | cid_32798 | SMR000058745 | CLOBETAS...)
Affinity DataIC50: 44nMAssay Description:Inhibition of CYP3A5 in wild type human AsPC1 cells assessed as decrease in 1-hydroxymidazolam formation using midazolam as substrate after 24 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50123453(CHEMBL3623290)
Affinity DataIC50: 50nMAssay Description:Inhibition of CYP3A5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM39347(MLS000028708 | cid_32798 | SMR000058745 | CLOBETAS...)
Affinity DataIC50: 78nMAssay Description:Inhibition of CYP3A5 in lentiviral pLVX-TRE3G-ZsGreen1-CYP3A5 transduced wild type human AsPC1 cells overexpressing CYP3A5 assessed as decrease in 1-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM39347(MLS000028708 | cid_32798 | SMR000058745 | CLOBETAS...)
Affinity DataIC50: 103nMAssay Description:Inhibition of CYP3A5 in CRISPR/Cas9-mediated CYP3A5 knock-out and doxycycline-induced CYP3A5 overexpressing human AsPC1 cells assessed as decrease in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM151585(US8987315, Ketoconazole | US9180183, Ketoconazole ...)
Affinity DataIC50: 120nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2016
Entry Details
Go to US Patent

TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM151585(US8987315, Ketoconazole | US9180183, Ketoconazole ...)
Affinity DataIC50: 120nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2016
Entry Details
Go to US Patent

TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50030448(CHEMBL269732 | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN ...)
Affinity DataIC50: 140nMAssay Description:Inhibition of human CYP3A5 expressed in supersomes assessed inhibition of 1'-OH midazolam formation preincubated with compound before substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataIC50: 141nMAssay Description:Inhibition of CYP3A5 in doxycycline-induced CYP3A5 overexpressing wild type human AsPC1 cells assessed as decrease in 1-hydroxymidazolam formation us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataIC50: 162nMAssay Description:Inhibition of CYP3A5 in CRISPR/Cas9-mediated CYP3A5 knock-out and doxycycline-induced CYP3A5 overexpressing human AsPC1 cells assessed as decrease in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490735(DNDI1449875 | CHEMBL1863002)
Affinity DataIC50: 300nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataIC50: 439nMAssay Description:Inhibition of CYP3A5 in lentiviral pLVX-TRE3G-ZsGreen1-CYP3A5 transduced wild type human AsPC1 cells overexpressing CYP3A5 assessed as decrease in 1-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataIC50: 513nMAssay Description:Inhibition of CYP3A5 in wild type human AsPC1 cells assessed as decrease in 1-hydroxymidazolam formation using midazolam as substrate after 24 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50081468(CHEMBL3422028)
Affinity DataIC50: 556nMAssay Description:Inhibition of human recombinant CYP3A5 assessed as metabolism of 7-benzyloxy-4-trifluoromethylcoumarin to HFC after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50014757(CHEMBL137192 | (4-Chloro-phenyl)-(2-chloro-phenyl)...)
Affinity DataIC50: 600nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490750(CHEMBL2334336)
Affinity DataIC50: 600nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50030448(CHEMBL269732 | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN ...)
Affinity DataIC50: 630nMAssay Description:Inhibition of human CYP3A5 expressed in supersomes assessed inhibition of 1'-OH midazolam formation by LC-MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50435005(CHEMBL2386285)
Affinity DataIC50: 723nMAssay Description:Inhibition of human recombinant CYP3A5 assessed as metabolism of 7-benzyloxy-4-trifluoromethylcoumarin to HFC after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490748(DNDI1435775 | CHEMBL1863056)
Affinity DataIC50: 810nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50113995(CHEMBL3605542)
Affinity DataIC50: 830nMAssay Description:Inhibition of CYP3A5 in human liver microsomes incubated for 5 mins in presence of NADPH and specific substrates by LC/MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485474(DNDI1322027 | CHEMBL1862838)
Affinity DataIC50: 900nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50364653(CHEMBL1951443)
Affinity DataIC50: 980nMAssay Description:Inhibition of recombinant human CYP3A5 in supersomes using midazolam as substrate after 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490737(DNDI1538112 | CHEMBL1863288)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490744(DNDI1467768 | CHEMBL1862905)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485473(DNDI1336037 | CHEMBL1863499)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490736(DNDI1343536 | CHEMBL1863145)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485466(DNDI1335913 | CHEMBL1863004)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485471(DNDI1335912 | CHEMBL1863383)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50364661(CHEMBL1951339)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of recombinant human CYP3A5 in supersomes using midazolam as substrate after 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490742(DNDI1460901 | CHEMBL1863462)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485476(DNDI1294211 | CHEMBL1863160)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490743(DNDI1434940 | CHEMBL1863046)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490749(DNDI1434923 | CHEMBL1862798)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490753(DNDI1465083 | CHEMBL1863455)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50584760(CHEMBL2068968)
Affinity DataIC50: 2.34E+3nMAssay Description:Time dependent inhibition of recombinant human CYP3A5 using midazolam as substrate preincubated for 30 mins in presence of NADPH generating system fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485475(DNDI1336031 | CHEMBL1863146)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50584761(BUFALIN | CHEBI:517248 | Bufalin)
Affinity DataIC50: 2.76E+3nMAssay Description:Time dependent inhibition of recombinant human CYP3A5 incubated for 30 mins in presence of NADPH generating system by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490741(CHEMBL2334337)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490751(DNDI1434944 | CHEMBL1863306)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490745(DNDI1338491 | CHEMBL1863273)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485468(DNDI1467766 | CHEMBL1863039)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490746(DNDI1388149 | CHEMBL1863393)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490752(DNDI1551253 | CHEMBL1862941)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485467(DNDI1574842 | CHEMBL1863325)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485470(DNDI1342987 | CHEMBL1863007)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50265673(CHEMBL4068611)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of CYP3A5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485469(DNDI1268111 | CHEMBL1863183)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
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