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TargetMuscarinic acetylcholine receptor M3(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193784(US9670209, Compound 302 1-((R)-3-((1R,3R,5S)-3-(cy...)
Affinity DataEC50:  160nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193787(US9670209, Compound 304 1-((R)-3-(3-(Cyclopropylme...)
Affinity DataEC50:  40nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193789(US9670209, Compound 307 1-((R)-3-(3-(Cyclopropylme...)
Affinity DataEC50:  50nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193790(US9670209, Compound 308 1-((R)-3-(3-(Allyloxy)-8-a...)
Affinity DataEC50:  500nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193791(US9670209, Compound 309 1-((R)-3-(3-(2-Methoxyethy...)
Affinity DataEC50:  130nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193802(US9670209, Compound 312 1-((R)-3-(3-(cyclopropylme...)
Affinity DataEC50:  500nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193787(US9670209, Compound 304 1-((R)-3-(3-(Cyclopropylme...)
Affinity DataEC50:  40nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | VEMURAFENIB | US...)
Affinity DataEC50:  4.00E+3nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193834(US9670209, Comparative compound 2)
Affinity DataEC50:  79nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM43819(ethyl 4-[2-(thiophen-2-ylcarbonylamino)ethylamino]...)
Affinity DataEC50:  7.70E+4nMAssay Description:Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Grant Title: Discovery of novel allosteric modulators of the M1 mus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
TargetMuscarinic acetylcholine receptor M3(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM43820(4-[2-[[(2-chlorophenyl)-oxomethyl]amino]ethylamino...)
Affinity DataEC50:  5.93E+4nMAssay Description:Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Grant Title: Discovery of novel allosteric modulators of the M1 mus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
TargetMuscarinic acetylcholine receptor M3(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM43821(4-(2-benzamidoethylamino)-1-piperidinecarboxylic a...)
Affinity DataEC50:  1.24E+4nMAssay Description:Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Grant Title: Discovery of novel allosteric modulators of the M1 mus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
TargetMuscarinic acetylcholine receptor M3(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM43822(ethyl 4-[2-[(2-methylbenzoyl)amino]ethylamino]pipe...)
Affinity DataEC50:  3.60E+5nMAssay Description:Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Grant Title: Discovery of novel allosteric modulators of the M1 mus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
TargetMuscarinic acetylcholine receptor M3(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM50313639(cid_44251554 | CHEMBL1084941 | VU0365137 | 1-(4-(1...)
Affinity DataEC50:  2.71E+3nMAssay Description:Selective M1 activation is an attractive therapeutic approach for the treatment of cognitive impairment, Alzheimer's disease, schizophrenia and a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2011
Entry Details
PCBioAssay
TargetMuscarinic acetylcholine receptor M3(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM50079583(WAY-132983 | (R)-3-(3-Hexylsulfanyl-pyrazin-2-ylox...)
Affinity DataEC50:  3.70nMAssay Description:In vitro functional agonism against M3 muscarinic receptor (PI)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50229048(CHEMBL349844)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229049(CHEMBL351934)
Affinity DataEC50:  100nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229050(CHEMBL422710)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229054(CHEMBL161748)
Affinity DataEC50:  1.28E+3nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229057(CHEMBL161419)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229059(CHEMBL159708)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229053(CHEMBL161364)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229052(CHEMBL159651)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229051(CHEMBL159935)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229064(CHEMBL159839)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229055(CHEMBL161670)
Affinity DataEC50:  1.46E+3nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50046728(1-Methyl-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-1,2,3,...)
Affinity DataEC50:  32nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229058(CHEMBL161088)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50228565(CHEMBL108557)
Affinity DataKd:  7.00E+3nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228566(CHEMBL2092932)
Affinity DataKd:  3.23E+3nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228567(CHEMBL2092931)
Affinity DataKd:  7.85E+3nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228568(CHEMBL322126)
Affinity DataKd:  1.60E+4nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228569(CHEMBL1788225)
Affinity DataKd:  161nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228570(CHEMBL1788202)
Affinity DataKd:  200nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228571(CHEMBL107456)
Affinity DataKd:  97nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228572(CHEMBL432629)
Affinity DataKd:  110nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228573(CHEMBL106056)
Affinity DataKd:  3.55E+3nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228071(CHEMBL110892)
Affinity DataKd:  1.40E+3nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228574(CHEMBL108582)
Affinity DataKd:  8.30E+3nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228087(CHEMBL323032)
Affinity DataKd:  1.25E+5nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228575(CHEMBL108140)
Affinity DataEC50:  2.80E+3nMAssay Description:Compound was tested for its potency against Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228576(CHEMBL2092930)
Affinity DataKd:  80nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228577(CHEMBL1788224)
Affinity DataKd:  1.16E+3nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50004656((2-Hydroxyethyl)trimethyl ammonium chloride carbam...)
Affinity DataEC50:  100nMAssay Description:Compound was tested for its potency against Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228578(CHEMBL111327)
Affinity DataKd:  4.95E+4nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228579(CHEMBL1788219)
Affinity DataKd:  6.32E+3nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228578(CHEMBL111327)
Affinity DataEC50:  7.50E+3nMAssay Description:Compound was tested for its potency against Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228570(CHEMBL1788202)
Affinity DataEC50:  94nMAssay Description:Compound was tested for its potency against Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50403547(ATROPEN | ATROPINE)
Affinity DataKd:  0.900nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50229065(CHEMBL262517)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
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