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TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470392(CHEMBL4283208)
Affinity DataIC50: 3nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470403(CHEMBL4294467)
Affinity DataIC50: 4nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470400(CHEMBL4289998)
Affinity DataIC50: 4nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470394(CHEMBL4281775)
Affinity DataIC50: 8nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470395(CHEMBL4279313)
Affinity DataIC50: 9nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470405(CHEMBL4289650)
Affinity DataIC50: 10nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470393(CHEMBL4291061)
Affinity DataIC50: 12nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470404(CHEMBL4279382)
Affinity DataIC50: 14nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470402(CHEMBL4278317)
Affinity DataIC50: 21nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470399(CHEMBL4286573)
Affinity DataIC50: 23nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470406(CHEMBL4295081)
Affinity DataIC50: 24nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470398(CHEMBL4286232)
Affinity DataIC50: 25nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM737448(US20250136618, Compound 4)
Affinity DataIC50: 44nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/3/2025
Entry Details
Go to US Patent

TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM737446(US20250136618, Compound 2)
Affinity DataIC50: 45nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/3/2025
Entry Details
Go to US Patent

TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470396(CHEMBL4293447)
Affinity DataIC50: 49nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM595423(US11590142, Compound 13 | US20250136618, Compound ...)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2025
Entry Details
Go to US Patent

TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM737447(US20250136618, Compound 3)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/3/2025
Entry Details
Go to US Patent

TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM737454(US20250136618, Compound 10)
Affinity DataIC50: 78nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/3/2025
Entry Details
Go to US Patent

TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM737453(US20250136618, Compound 9)
Affinity DataIC50: 91nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/3/2025
Entry Details
Go to US Patent

TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM737449(US20250136618, Compound 5)
Affinity DataIC50: 110nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/3/2025
Entry Details
Go to US Patent

TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM737450(US20250136618, Compound 6)
Affinity DataIC50: 130nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/3/2025
Entry Details
Go to US Patent

TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470401(CHEMBL4290062)
Affinity DataIC50: 200nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470397(CHEMBL4294536)
Affinity DataIC50: 400nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50006565(CHEMBL3235085)
Affinity DataIC50: 700nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50058511(CHEMBL3329318)
Affinity DataIC50: 780nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50058509(CHEMBL3329317)
Affinity DataIC50: 940nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470407(CHEMBL4286625)
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM21690(Ciprinol | 1-cyclopropyl-6-fluoro-4-oxo-7-(piperaz...)
Affinity DataIC50: 1.44E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2025
Entry Details
Go to US Patent

TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50058510(CHEMBL3329319)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM24616(N-cyclopropyl-1-{2-[(ethylcarbamoyl)amino]-7-(pyri...)
Affinity DataKi:  7nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM24617(3-ethyl-1-[7-(3-fluoropyridin-2-yl)-5-(1-methyl-2-...)
Affinity DataKi:  11nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM24615(N-cyclopropyl-1-{2-[(ethylcarbamoyl)amino]-7-(1H-p...)
Affinity DataKi:  12nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM24609(3-ethyl-1-[7-(pyridin-2-yl)-5-(pyridin-3-yl)-1H-1,...)
Affinity DataKi:  14nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM24611(3-ethyl-1-[7-(3-fluoropyridin-2-yl)-5-(pyridin-3-y...)
Affinity DataKi:  23nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM24606(methyl 2-[(ethylcarbamoyl)amino]-5-(pyridin-3-yl)-...)
Affinity DataKi:  35nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM24608(3-ethyl-1-[7-(1H-pyrazol-1-yl)-5-(pyridin-3-yl)-1H...)
Affinity DataKi:  46nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM24614(3-ethyl-1-[7-(1H-pyrazol-1-yl)-5-(pyrimidin-5-yl)-...)
Affinity DataKi:  58nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM24601(N-cyclopropyl-1-{2-[(ethylcarbamoyl)amino]-6-fluor...)
Affinity DataKi:  78nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM282(Coumarin-Based, DNA Gyrase Inhibitor | (3R,4S,5R,6...)
Affinity DataKi:  110nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM24607(2-[(ethylcarbamoyl)amino]-N-methyl-5-(pyridin-3-yl...)
Affinity DataKi:  150nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM24612(1-[7-(benzyloxy)-5-(pyridin-3-yl)-1H-1,3-benzodiaz...)
Affinity DataKi:  390nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM24602(3-ethyl-1-[6-fluoro-5-(pyridin-3-yl)-1H-1,3-benzod...)
Affinity DataKi:  680nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM24613(3-ethyl-1-[6-methoxy-5-(2-methoxypyrimidin-5-yl)-1...)
Affinity DataKi:  680nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM24600(3-ethyl-1-[5-(pyrimidin-5-yl)-1H-1,3-benzodiazol-2...)
Affinity DataKi:  1.10E+3nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM24610(1-[5,7-bis(pyridin-3-yl)-1H-1,3-benzodiazol-2-yl]-...)
Affinity DataKi:  1.30E+3nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM24603(3-ethyl-1-[6-methyl-5-(pyridin-3-yl)-1H-1,3-benzod...)
Affinity DataKi:  1.40E+3nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM24598(3-ethyl-1-[5-(pyridin-3-yl)-1H-1,3-benzodiazol-2-y...)
Affinity DataKi:  2.30E+3nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM24605(3-ethyl-1-[6-(piperidin-1-yl)-5-(pyridin-3-yl)-1H-...)
Affinity DataKi:  3.30E+3nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM24604(3-ethyl-1-[6-methoxy-5-(pyridin-3-yl)-1H-1,3-benzo...)
Affinity DataKi:  3.50E+3nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Bugworks Research India

US Patent
LigandPNGBDBM24599(3-ethyl-1-(5-phenyl-1H-1,3-benzodiazol-2-yl)urea |...)
Affinity DataKi:  9.50E+3nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
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