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TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50038276(7-[(3-Iodo-allyl)-propyl-amino]-5,6,7,8-tetrahydro...)
Affinity DataKd:  0.480nMAssay Description:Binding affinity was tested against dopamine receptor D3 in rat striatal membrane homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50020222(CHEMBL285755 | 7-Dipropylamino-5,6,7,8-tetrahydro-...)
Affinity DataKd:  0.670nMAssay Description:Tested for binding affinity against dopamine receptor D3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50043603(7-[(3-Iodo-allyl)-propyl-amino]-5,6,7,8-tetrahydro...)
Affinity DataKd:  0.0500nMAssay Description:Binding affinity was tested against dopamine receptor D3 in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50038276(7-[(3-Iodo-allyl)-propyl-amino]-5,6,7,8-tetrahydro...)
Affinity DataKd:  0.130nMAssay Description:Binding affinity was tested against dopamine receptor D3 in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50010586(CHEMBL70565 | (-)-1-Propyl-2,3,10,10a-tetrahydro-1...)
Affinity DataEC50:  0.360nMAssay Description:Agonist activity by measuring the [3H]-thymidine uptake against Dopamine receptor D3 from ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  1.70nMAssay Description:Agonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50090832((cis)1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4-oxa-9...)
Affinity DataEC50:  36nMAssay Description:Agonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50090828((-)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4-oxa-9-...)
Affinity DataEC50:  0.00700nMAssay Description:Agonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50092169(N*7*,N*7*-Dipropyl-7,8-dihydro-6H-1-thia-3-aza-as-...)
Affinity DataEC50: >1.00E+3nMAssay Description:Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assay (intrin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50092170(N*8*,N*8*-Dipropyl-8,9-dihydro-7H-chromeno[6,5-d]t...)
Affinity DataEC50: >1.00E+3nMAssay Description:Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50092173(N*6*,N*6*-Dipropyl-6,7-dihydro-5H-1-thia-3-aza-s-i...)
Affinity DataEC50: >1.00E+3nMAssay Description:Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assay (intrin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  80nMAssay Description:Basal binding towards Dopamine receptor D3 was evaluated using [35S]- GTP-gamma S radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKd:  0.334nMAssay Description:Compound was tested for its effect on dopamine saturation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50487259(CHEBI:64219 | [3H]NEMONAPRIDE)
Affinity DataKd:  0.0640nMAssay Description:Binding affinity to Rattus norvegicus (rat) wild type dopamine D3 receptor transfected in african green monkey COS7 cells after 1 hr by beta scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50487259(CHEBI:64219 | [3H]NEMONAPRIDE)
Affinity DataKd:  0.0600nMAssay Description:Binding affinity to Rattus norvegicus (rat) chimeric dopamine D3 trunk/D3 tail receptor transfected in african green monkey COS7 cells after 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50219939(N-((1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1...)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50382302(CHEMBL2024516)
Affinity DataIC50: 0.260nMAssay Description:Displacement of [3H]spiperone from rat recombinant dopamine D3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 0.280nMAssay Description:Ability to inhibit [3H]haloperidol binding to dopamine receptor in rat striatal homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50382300(CHEMBL2024514)
Affinity DataIC50: 0.290nMAssay Description:Displacement of [3H]spiperone from rat recombinant dopamine D3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50219946(N-((1r,4r)-4-(2-(4-(3-(trifluoromethyl)phenyl)pipe...)
Affinity DataIC50: 0.300nMAssay Description:Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50020220(CHEMBL38428 | 3-Dipropylamino-chroman-8-ol)
Affinity DataIC50: 0.320nMAssay Description:In vitro affinity to dopamine receptor using [3H]NPAD as radioligand in rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2019
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50382304(CHEMBL2024520)
Affinity DataIC50: 0.320nMAssay Description:Displacement of [3H]spiperone from rat recombinant dopamine D3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50382313(CHEMBL2024518)
Affinity DataIC50: 0.340nMAssay Description:Displacement of [3H]spiperone from rat recombinant dopamine D3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50219943(N-((1r,4r)-4-(2-(4-(3-cyano-5-(trifluoromethyl)phe...)
Affinity DataIC50: 0.400nMAssay Description:Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 0.400nMAssay Description:Binding affinity against dopamine receptor in rat striatal membrane using [3H]haloperidolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2018
Entry Details Article
PubMed
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2018
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50382299(CHEMBL2024513)
Affinity DataIC50: 0.410nMAssay Description:Displacement of [3H]spiperone from rat recombinant dopamine D3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50119380(CHEMBL540612 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataIC50: 0.410nMAssay Description:Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D3 receptor transfected in african green monkey COS7 cells after 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50382301(CHEMBL2024515)
Affinity DataIC50: 0.480nMAssay Description:Displacement of [3H]spiperone from rat recombinant dopamine D3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50219940(N-((1r,4r)-4-(2-(4-(3-(trifluoromethyl)benzyl)pipe...)
Affinity DataIC50: 0.5nMAssay Description:Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50219944(N-((1r,4r)-4-(2-(4-(4-bromo-2-methoxyphenyl)pipera...)
Affinity DataIC50: 0.5nMAssay Description:Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50225369(CHEMBL295712)
Affinity DataIC50: 0.610nMAssay Description:Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2018
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50382303(CHEMBL2024519)
Affinity DataIC50: 0.620nMAssay Description:Displacement of [3H]spiperone from rat recombinant dopamine D3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50219945(N-((1r,4r)-4-(2-(4-(3-cyano-5-(trifluoromethyl)phe...)
Affinity DataIC50: 0.700nMAssay Description:Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50219947(N-((1r,4r)-4-(2-(4-(3-cyanophenyl)piperazin-1-yl)e...)
Affinity DataIC50: 0.700nMAssay Description:Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50119380(CHEMBL540612 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataIC50: 0.720nMAssay Description:Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D3 trunk/D3 tail receptor transfected in african green monkey COS7 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50219935(N-[4-(4-{2-[4-(3-cyano-5-trifluoromethyl-phenyl)-p...)
Affinity DataIC50: 0.900nMAssay Description:Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50382292(CHEMBL2024509)
Affinity DataIC50: 0.900nMAssay Description:Displacement of [3H]spiperone from rat recombinant dopamine D3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50007518(3-Chloro-5-ethyl-N-((S)-1-ethyl-pyrrolidin-2-ylmet...)
Affinity DataIC50: 0.920nMAssay Description:Antidopamine activity in vitro by ability to displace [3H]spiperone from rat brain striatal preparations.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2018
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50219949(3-oxo-N-((1r,4r)-4-(2-(4-(3-(trifluoromethyl)pheno...)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50001955(APOKYN | CHEMBL53 | (Apomorphine) 6-Methyl-5,6,6a,...)
Affinity DataIC50: 1nMAssay Description:Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50001955(APOKYN | CHEMBL53 | (Apomorphine) 6-Methyl-5,6,6a,...)
Affinity DataIC50: 1.10nMAssay Description:Dopaminergic activity assessed in vitro for displacement of [3H]apomorphine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2018
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50020222(CHEMBL285755 | 7-Dipropylamino-5,6,7,8-tetrahydro-...)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D3 trunk/D3 tail receptor transfected in african green monkey COS7 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50070571(5-Bromo-N-((R)-1-ethyl-4-methyl-[1,4]diazepan-6-yl...)
Affinity DataIC50: 1.13nMAssay Description:Concentration of compound required to inhibit the binding of radioligand [3H](R)-7-OH-DPAT to Dopamine receptor D3 in rat striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50020222(CHEMBL285755 | 7-Dipropylamino-5,6,7,8-tetrahydro-...)
Affinity DataIC50: 1.30nMAssay Description:Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D3 receptor transfected in african green monkey COS7 cells after 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50001955(APOKYN | CHEMBL53 | (Apomorphine) 6-Methyl-5,6,6a,...)
Affinity DataIC50: 1.40nMAssay Description:Inhibitory concentration for half-maximal displacement of 1.0 nM [3H]ADTN specific binding from rat striatal membranes using 10E-5 sulpirideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2018
Entry Details Article
PubMed
LigandPNGBDBM50225774(CHEMBL161122)
Affinity DataIC50: 1.5nMAssay Description:Antidopamine activity in vitro by ability to displace [3H]spiperone from rat brain striatal preparations.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2018
Entry Details Article
PubMed
LigandPNGBDBM50017543(9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of [3H]apomorphine binding to dopamine receptor of rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50382290(RGH-188 HCL | CARIPRAZINE HYDROCHLORIDE | US202402...)
Affinity DataIC50: 1.60nMAssay Description:Displacement of [3H]spiperone from rat recombinant dopamine D3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
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