Compile Data Set for Download or QSAR
Report error Found 415 of affinity data for UniProtKB/TrEMBL: P14600
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM21010(H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NH-Bzl | (2S)-2-{[...)
Affinity DatapH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2008
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM21011(H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NMe-Bzl | (2S)-2-{...)
Affinity DatapH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2008
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50002462(1,3-Diethyl-2-[3-(1,3,3-trimethyl-1,3-dihydro-indo...)
Affinity DataKd:  0.970nMAssay Description:Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50002462(1,3-Diethyl-2-[3-(1,3,3-trimethyl-1,3-dihydro-indo...)
Affinity DataKd:  1.5nMAssay Description:Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50002462(1,3-Diethyl-2-[3-(1,3,3-trimethyl-1,3-dihydro-indo...)
Affinity DataKd:  0.180nMAssay Description:Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50108639(CHEMBL3596448)
Affinity DataIC50: 0.0300nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50108638(CHEMBL3596447)
Affinity DataIC50: 0.0500nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50108631(CHEMBL3596446)
Affinity DataIC50: 0.0500nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50220136(CHEMBL1471 | 5-(((2R,3S)-2-((R)-1-(3,5-bis(trifluo...)
Affinity DataIC50: 0.0900nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50290861(5-{3-[1-(3,5-Dichloro-phenyl)-ethoxy]-2-phenyl-pip...)
Affinity DataIC50: 0.0900nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of Tachykinin receptor 1 of rat forebrain tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 0.120nMAssay Description:Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50009228(CHEMBL413846 | SP (substance P) | Spantide)
Affinity DataIC50: 0.120nMAssay Description:Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50290865(3-[1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2-ph...)
Affinity DataIC50: 0.150nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50290856(3-[1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2-ph...)
Affinity DataIC50: 0.160nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50290859(5-{3-[1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2...)
Affinity DataIC50: 0.160nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50052280((2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-ph...)
Affinity DataIC50: 0.180nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50106366(CHEMBL3596493)
Affinity DataIC50: 0.25nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50106365(CHEMBL3596492)
Affinity DataIC50: 0.290nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50106358(CHEMBL3596485)
Affinity DataIC50: 0.320nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 0.370nMAssay Description:Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50106367(CHEMBL3596494)
Affinity DataIC50: 0.390nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 0.410nMAssay Description:Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50106356(CHEMBL3596483)
Affinity DataIC50: 0.450nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50407164(CHEMBL2115376)
Affinity DataIC50: 0.600nMAssay Description:Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 0.640nMAssay Description:Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50614481(CHEMBL5269970)
Affinity DataIC50: 0.640nMAssay Description:Inhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50229589(Arg-Pro-Lys-Pro-Ala-Gln-Phe-Phe-Gly-Leu-Met-NH2 | ...)
Affinity DataIC50: 0.740nMAssay Description:Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50049468((2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-ph...)
Affinity DataIC50: 0.800nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50106359(CHEMBL3596486)
Affinity DataIC50: 0.910nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50290863(3-[1-(3,5-Dichloro-phenyl)-ethoxy]-2-phenyl-piperi...)
Affinity DataIC50: 0.910nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50108630(CHEMBL3596482)
Affinity DataIC50: 0.930nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM21021(H-Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-O-3,5-Bzl(CF3)...)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50106361(CHEMBL3596488)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50106357(CHEMBL3596484)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2018
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50106362(CHEMBL3596489)
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50049309(N-[(R)-1-{[Acetyl-(2-methoxy-benzyl)-amino]-methyl...)
Affinity DataIC50: 1.5nMAssay Description:Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 1.5nMAssay Description:Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50108637(CHEMBL3596456)
Affinity DataIC50: 1.60nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50106368(CHEMBL3596495)
Affinity DataIC50: 1.80nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50106364(CHEMBL3596491)
Affinity DataIC50: 1.90nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50106369(CHEMBL3596496)
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50284880(2-[1-Imino-2-(2-methoxy-phenyl)-ethyl]-4,4-dipheny...)
Affinity DataIC50: 2nMAssay Description:Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50106388(CHEMBL3596476)
Affinity DataIC50: 2.20nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50449782(CHEMBL2370874)
Affinity DataIC50: 2.30nMAssay Description:Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50030166(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Pen(S-Me)-Gly-Leu-Met ...)
Affinity DataIC50: 2.40nMAssay Description:Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50030158(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Flg-Gly-Leu-Met | CHEM...)
Affinity DataIC50: 2.5nMAssay Description:Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona Tucson

LigandPNGBDBM50030146(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Tle-Gly-Leu-Met | CHEM...)
Affinity DataIC50: 2.60nMAssay Description:Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
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