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Report error Found 2666 for UniProtKB: P10980
LigandPNGBDBM50281902((R)-2-[2-(10H-Anthracen-9-ylidene)-ethyl]-1-methyl...)
Affinity DataKd:  3nMAssay Description:Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

LigandPNGBDBM50281903((S)-2-[(E)-2-(9,10-Dihydro-anthracen-9-yl)-vinyl]-...)
Affinity DataKd:  21nMAssay Description:Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

LigandPNGBDBM50403547(ATROPEN | ATROPINE)
Affinity DataKd:  2.70nMAssay Description:In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataKd:  3nMAssay Description:In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50031098((E)-(R)-2-Hydroxy-5-iodo-2-phenyl-pent-4-enoic aci...)
Affinity DataKd:  41nMAssay Description:In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50453895(CHEMBL2111842)
Affinity DataKd:  0.430nMAssay Description:In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50450592(CHEMBL558910)
Affinity DataKd:  0.200nMAssay Description:In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50263887(1-(1'-2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-be...)
Affinity DataEC50: >3.00E+4nMAssay Description:Partial agonist activity at rat muscarinic M2 receptor expressed in CHO cells calcium responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50023229(CHEMBL3329755)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at rat muscarinic acetylcholine receptor subtype 2 expressed in CHO cells co-transfected with chimeric Gqi5 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMed
LigandPNGBDBM50280521((4R,5S)-5-Methyl-4-[(E)-3-((R)-1-methyl-piperidin-...)
Affinity DataKd:  1.21E+3nMAssay Description:Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50076089((3S,3aR,4R,4aS,8aR,9aS)-4-[(E)-2-((1S,2R,6S)-1,6-D...)
Affinity DataKd:  3nMAssay Description:Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50258723(7-chloro-1-(4-(trifluoromethyl)benzyl)indoline-2,3...)
Affinity DataEC50:  2.84E+3nMAssay Description:Activation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50280521((4R,5S)-5-Methyl-4-[(E)-3-((R)-1-methyl-piperidin-...)
Affinity DataKd:  1.21E+3nMAssay Description:Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

LigandPNGBDBM50281906(2-[(E)-2-(9,9a-Dihydro-4aH-xanthen-9-yl)-vinyl]-1-...)
Affinity DataKd:  25nMAssay Description:Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

LigandPNGBDBM50281905(2-[3-(10H-Anthracen-9-ylidene)-propyl]-1-methyl-pi...)
Affinity DataKd:  7.60nMAssay Description:Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

LigandPNGBDBM50281908(2-((E)-2-Anthracen-9-yl-vinyl)-1-methyl-piperidine...)
Affinity DataKd:  635nMAssay Description:Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

LigandPNGBDBM50281909((R)-2-[(E)-2-(9,10-Dihydro-anthracen-9-yl)-vinyl]-...)
Affinity DataKd:  3.20nMAssay Description:Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

LigandPNGBDBM50076089((3S,3aR,4R,4aS,8aR,9aS)-4-[(E)-2-((1S,2R,6S)-1,6-D...)
Affinity DataKd:  9.10nMAssay Description:Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

LigandPNGBDBM50281904(2-[(E)-3-(9,10-Dihydro-anthracen-9-yl)-allyl]-1-me...)
Affinity DataKd:  23nMAssay Description:Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

LigandPNGBDBM50281907((S)-2-[2-(10H-Anthracen-9-ylidene)-ethyl]-1-methyl...)
Affinity DataKd:  35nMAssay Description:Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

LigandPNGBDBM50284319((2S,6R)-1,2-Dimethyl-6-[(E)-2-((3S,3aR,4R,4aS,8aR,...)
Affinity DataKd:  353nMAssay Description:Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

LigandPNGBDBM50284321(Acetic acid (S)-1-{(1R,2R,3S,4aR,8aS)-3-acetoxymet...)
Affinity DataKd:  249nMAssay Description:Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

LigandPNGBDBM50284320((S)-1-{(1R,2R,3S,4aR,8aS)-1-[(E)-2-((2R,6S)-1,6-Di...)
Affinity DataKd:  293nMAssay Description:Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

LigandPNGBDBM50284322(Acetic acid (1R,3S,3aR,4R,4aS,8aR,9aS)-4-[(E)-2-((...)
Affinity DataKd:  89nMAssay Description:Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

LigandPNGBDBM50284323(2,2-Dimethyl-propionic acid (1R,3S,3aR,4R,4aS,8aR,...)
Affinity DataKd:  464nMAssay Description:Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

LigandPNGBDBM50076089((3S,3aR,4R,4aS,8aR,9aS)-4-[(E)-2-((1S,2R,6S)-1,6-D...)
Affinity DataKd:  10nMAssay Description:Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

LigandPNGBDBM50284324((1S,3S,3aR,4R,4aS,8aR,9aS)-4-[(E)-2-((2R,6S)-1,6-D...)
Affinity DataKd:  96nMAssay Description:Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
LigandPNGBDBM50258723(7-chloro-1-(4-(trifluoromethyl)benzyl)indoline-2,3...)
Affinity DataEC50:  2.80E+3nMAssay Description:Agonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
LigandPNGBDBM50258656(VU0238429 | CHEMBL466253 | cid_42633508 | 1-(4-met...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
LigandPNGBDBM50356972(CHEMBL1916234)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at rat muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50356973(CHEMBL1916235)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at rat muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM43822(ethyl 4-[2-[(2-methylbenzoyl)amino]ethylamino]pipe...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat recombinant muscarinic M2 receptor by HTS cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50356966(CHEMBL1916224)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat recombinant muscarinic M2 receptor by HTS cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM43822(ethyl 4-[2-[(2-methylbenzoyl)amino]ethylamino]pipe...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50356966(CHEMBL1916224)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50356968(CHEMBL1916225)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at rat muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50356969(CHEMBL1916226)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at rat muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50356970(CHEMBL1916227)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at rat muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50356974(CHEMBL1916229)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at rat muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50356975(CHEMBL1916230)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at rat muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50356976(CHEMBL1916231)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at rat muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50356977(CHEMBL1916232)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at rat muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50356978(CHEMBL1916233)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at rat muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50356971(CHEMBL1916228)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at rat muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50015721(CHEMBL553066 | 3-Hydroxy-2-phenyl-propionic acid 8...)
Affinity DataKd:  1.60nMAssay Description:In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50015719(CHEMBL544993 | 3-Hydroxy-2-phenyl-propionic acid 9...)
Affinity DataKd:  10nMAssay Description:In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50015724(CHEMBL544759 | 3-Hydroxy-2-phenyl-propionic acid 9...)
Affinity DataKd:  6.70nMAssay Description:In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50015727(CHEMBL293927 | 7-(3-Hydroxy-2-phenyl-propionyloxy)...)
Affinity DataKd:  0.870nMAssay Description:In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50015726(CHEMBL553562 | 3-Hydroxy-2-phenyl-propionic acid 9...)
Affinity DataKd:  23nMAssay Description:In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
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