Affinity DataEC50: 169nMAssay Description:Inhibition of Tau phosphorylation by cell based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 24nMAssay Description:Inhibition of Tau phosphorylation by cell based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 325nMAssay Description:Inhibition of Tau phosphorylation by cell based assayMore data for this Ligand-Target Pair
Affinity DataKd: 50nMAssay Description:Binding affinity human recombinant tau (243 to 375) expressed in Escherichia coli BL21(DE3)RIL after 1 hr by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKd: 2.36E+3nMAssay Description:Binding affinity to recombinant human tau (441 amino acid residues) aggregates expressed in Escherichia coli assessed as apparent dissociation consta...More data for this Ligand-Target Pair
Affinity DataKd: 450nMAssay Description:Binding affinity to recombinant human tau (441 amino acid residues) aggregates expressed in Escherichia coli assessed as apparent dissociation consta...More data for this Ligand-Target Pair
Affinity DataKd: 300nMAssay Description:Binding affinity to recombinant human tau (441 amino acid residues) aggregates expressed in Escherichia coli assessed as apparent dissociation consta...More data for this Ligand-Target Pair
Affinity DataKd: 0.700nMAssay Description:Binding affinity to heparin induced human Tau 441 at 50 pM to 500 nM after 30 minsMore data for this Ligand-Target Pair
Affinity DataKd: 44.8nMAssay Description:Binding affinity to recombinant human tau expressed in Escherichia coli after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKd: 763nMAssay Description:Binding affinity to human Tau (1 to 441 residues) by ITC methodMore data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:Inhibition of tau-tau binding (unknown origin) assessed as increase in dissolved paired helical filamentsMore data for this Ligand-Target Pair
Affinity DataEC50: 590nMAssay Description:Inhibition of tau aggregation (unknown origin)More data for this Ligand-Target Pair
TargetIsoform Tau-F of Microtubule-associated protein tau(Human)
Centre National De La Recherche Scientifique
US Patent
Centre National De La Recherche Scientifique
US Patent
Affinity DataKd: 19.6nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
TargetIsoform Tau-F of Microtubule-associated protein tau(Human)
Centre National De La Recherche Scientifique
US Patent
Centre National De La Recherche Scientifique
US Patent
Affinity DataKd: 34.9nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
TargetIsoform Tau-F of Microtubule-associated protein tau(Human)
Centre National De La Recherche Scientifique
US Patent
Centre National De La Recherche Scientifique
US Patent
Affinity DataKd: 0.440nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
TargetIsoform Tau-F of Microtubule-associated protein tau(Human)
Centre National De La Recherche Scientifique
US Patent
Centre National De La Recherche Scientifique
US Patent
Affinity DataKd: 0.490nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
TargetIsoform Tau-F of Microtubule-associated protein tau(Human)
Centre National De La Recherche Scientifique
US Patent
Centre National De La Recherche Scientifique
US Patent
Affinity DataKd: 0.130nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
TargetIsoform Tau-F of Microtubule-associated protein tau(Human)
Centre National De La Recherche Scientifique
US Patent
Centre National De La Recherche Scientifique
US Patent
Affinity DataKd: 2.40nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
TargetIsoform Tau-F of Microtubule-associated protein tau(Human)
Centre National De La Recherche Scientifique
US Patent
Centre National De La Recherche Scientifique
US Patent
Affinity DataKd: 1.67nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
TargetIsoform Tau-F of Microtubule-associated protein tau(Human)
Centre National De La Recherche Scientifique
US Patent
Centre National De La Recherche Scientifique
US Patent
Affinity DataKd: 0.970nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
Affinity DataKd: 100nMAssay Description:(A) Expression and Purification of Human Tau: 1 mM IPTG (Sangon Biotech, Cat. No A100487) was used to induce production of tau by bacteria (BL21, Inv...More data for this Ligand-Target Pair
Affinity DataKd: 110nMAssay Description:(A) Expression and Purification of Human Tau: 1 mM IPTG (Sangon Biotech, Cat. No A100487) was used to induce production of tau by bacteria (BL21, Inv...More data for this Ligand-Target Pair
Affinity DataKd: 470nMAssay Description:(A) Expression and Purification of Human Tau: 1 mM IPTG (Sangon Biotech, Cat. No A100487) was used to induce production of tau by bacteria (BL21, Inv...More data for this Ligand-Target Pair
Affinity DataKd: 80nMAssay Description:(A) Expression and Purification of Human Tau: 1 mM IPTG (Sangon Biotech, Cat. No A100487) was used to induce production of tau by bacteria (BL21, Inv...More data for this Ligand-Target Pair
Affinity DataKd: 230nMAssay Description:(A) Expression and Purification of Human Tau: 1 mM IPTG (Sangon Biotech, Cat. No A100487) was used to induce production of tau by bacteria (BL21, Inv...More data for this Ligand-Target Pair
Affinity DataKd: 550nMAssay Description:(A) Expression and Purification of Human Tau: 1 mM IPTG (Sangon Biotech, Cat. No A100487) was used to induce production of tau by bacteria (BL21, Inv...More data for this Ligand-Target Pair
Affinity DataKd: 120nMAssay Description:(A) Expression and Purification of Human Tau: 1 mM IPTG (Sangon Biotech, Cat. No A100487) was used to induce production of tau by bacteria (BL21, Inv...More data for this Ligand-Target Pair
Affinity DataKd: 150nMAssay Description:(A) Expression and Purification of Human Tau: 1 mM IPTG (Sangon Biotech, Cat. No A100487) was used to induce production of tau by bacteria (BL21, Inv...More data for this Ligand-Target Pair
Affinity DataKd: 394nMAssay Description:Binding affinity to N-terminal His-tagged recombinant human Tau40 expressed in Escherichia coli Rosetta (DE3) assessed as dissociation constant incub...More data for this Ligand-Target Pair
Affinity DataEC50: 2.21E+3nMAssay Description:Inhibition of cellular tau (unknown origin) aggregation incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.71E+3nMAssay Description:Inhibition of cellular tau (unknown origin) aggregation incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 4.90E+3nMAssay Description:Binding affinity to tau (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of tau phosphorylation (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human microtubule associated protein tau aggregation by Thiazin-red R displacement fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:In the presence of 3 nM of the known tau ligand [3H]-THK5117 (Novandi Chemistry) and 0.2 mM 0N4R tau fibrils in binding buffer (50 mM Tris-HCl, pH 7....More data for this Ligand-Target Pair
Affinity DataIC50: 1.41nMAssay Description:Displacement of thiazine red R from human Tau aggregate expressed in Escherichia coli after 30 mins by fluorimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of tau phosphorylation (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of tau phosphorylation (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human microtubule associated protein tau aggregation by Thiazin-red R displacement fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human microtubule associated protein tau aggregation by Thiazin-red R displacement fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human microtubule associated protein tau aggregation by Thiazin-red R displacement fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Displacement of thiazene red from tau aggregateMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Displacement of thiazene red from tau aggregateMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of tau phosphorylation (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Inhibition of tau phosphorylation (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human microtubule associated protein tau aggregation by Thiazin-red R displacement fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:In the presence of 3 nM of the known tau ligand [3H]-THK5117 (Novandi Chemistry) and 0.2 mM 0N4R tau fibrils in binding buffer (50 mM Tris-HCl, pH 7....More data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Displacement of [3H]PI-2620 from Tau in human brain homogenate incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Displacement of [3H]PI-2620 from Tau in human brain homogenate incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Displacement of thiazene red from tau aggregateMore data for this Ligand-Target Pair
