Compile Data Set for Download or QSAR
Report error Found 551 of affinity data for UniProtKB/TrEMBL: P10398
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  1.34E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  8.15E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50507707(CHEMBL4466555)
Affinity DataIC50: 1nMAssay Description:Inhibition of human ARAF using MEK1 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50096279(CHEMBL3577124)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ARaf (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | VEMURAFENIB | US...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | VEMURAFENIB | US...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of ARaf (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM514652((S)-N-(3-(2-(((R)-1-hydroxypropan-2- yl)amino)-6-m...)
Affinity DataIC50: 2.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM704179(US12139488, Example 353)
Affinity DataIC50: 5.5nMAssay Description:In vitro enzymatic reactions were used for evaluating compounds intrinsic activity against BRAF, CRAF and ARAF. For BRAF and CRAF, 0.375 nM of purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/18/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM704187(Example 524 (Iron Metal as Reducing Agent for Step...)
Affinity DataIC50: 5.5nMAssay Description:In vitro enzymatic reactions were used for evaluating compounds intrinsic activity against BRAF, CRAF and ARAF. For BRAF and CRAF, 0.375 nM of purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/18/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM704198((Table 4) | US12139488, Example 679)
Affinity DataIC50: 5.5nMAssay Description:In vitro enzymatic reactions were used for evaluating compounds intrinsic activity against BRAF, CRAF and ARAF. For BRAF and CRAF, 0.375 nM of purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/18/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM372967(US9895376, Compound 2.2a | US10576087, Compound 2....)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of ARAF (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of ARaf (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50507709(CHEMBL4438236)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of ARaf (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM185591(US9156852, 116 | USRE47451, Example 116 | US121394...)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic reactions were used for evaluating compounds intrinsic activity against BRAF, CRAF and ARAF. For BRAF and CRAF, 0.375 nM of purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM372968(US9895376, Compound 2.2b | US10576087, Compound 2....)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic reactions were used for evaluating compounds intrinsic activity against BRAF, CRAF and ARAF. For BRAF and CRAF, 0.375 nM of purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM88120(US9694016, 1156 | US10245267, Example 1156 | US107...)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic reactions were used for evaluating compounds intrinsic activity against BRAF, CRAF and ARAF. For BRAF and CRAF, 0.375 nM of purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human ARAF using human His6-tagged MEK1 (K97R) as substrate preincubated for 20 mins followed by [33P-gamma]ATP addition and measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50085415(G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...)
Affinity DataIC50: 14.6nMAssay Description:Inhibition of human ARAF using MEK1 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50264689(CHEMBL4060057)
Affinity DataIC50: 18nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50264719(CHEMBL4075036)
Affinity DataIC50: 25nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50469204(CHEMBL4282601)
Affinity DataIC50: 25nMAssay Description:Inhibition of ARAF (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50428286(GSK2118436A | DABRAFENIB)
Affinity DataIC50: 26nMAssay Description:Competitive binding affinity to ARAF in human A375 cells after 15 mins in presence of ATP analogueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50469203(CHEMBL4289810)
Affinity DataIC50: 30nMAssay Description:Inhibition of ARAF (unknown origin) after 20 mins in presence of 33P-gamma-ATP by hotspot kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM192503(US9187474, 18)
Affinity DataIC50: 31nMAssay Description:Sample preparation: A375 cells from ATCC are lysed by sonication in commercially available lysis buffer, cleared by centrifugation, and the resulting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2016
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50264716(CHEMBL4087837)
Affinity DataIC50: 34nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50507705(CHEMBL4436132)
Affinity DataIC50: 36nMAssay Description:Inhibition of ARaf (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50264730(CHEMBL4080362)
Affinity DataIC50: 38nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50264691(CHEMBL4104590)
Affinity DataIC50: 41nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50264718(CHEMBL4085294)
Affinity DataIC50: 42nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50264690(CHEMBL4066939)
Affinity DataIC50: 43nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50096279(CHEMBL3577124)
Affinity DataIC50: 44nMAssay Description:Competitive binding affinity to ARAF in human A375 cells after 15 mins in presence of ATP analogueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50096279(CHEMBL3577124)
Affinity DataIC50: 44nMAssay Description:Inhibition of desthiobiotin-ATP acylphosphate probe binding to A-Raf in human A375 cells by MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50264717(CHEMBL4082425)
Affinity DataIC50: 47nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50507704(CHEMBL4586402)
Affinity DataIC50: 52nMAssay Description:Inhibition of ARaf (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50264731(CHEMBL4060531)
Affinity DataIC50: 57nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM192504(US9187474, 76)
Affinity DataIC50: 120nMAssay Description:Sample preparation: A375 cells from ATCC are lysed by sonication in commercially available lysis buffer, cleared by centrifugation, and the resulting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2016
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM185591(US9156852, 116 | USRE47451, Example 116 | US121394...)
Affinity DataIC50: 152nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50523706(CHEMBL4542639)
Affinity DataIC50: 183nMAssay Description:Inhibition of human ARAF using human His6-tagged MEK1 (K97R) as substrate preincubated for 20 mins followed by [33P-gamma]ATP addition and measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50264729(CHEMBL4101882)
Affinity DataIC50: 194nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50523707(CHEMBL4447617)
Affinity DataIC50: 211nMAssay Description:Inhibition of human ARAF using human His6-tagged MEK1 (K97R) as substrate preincubated for 20 mins followed by [33P-gamma]ATP addition and measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM185674(Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...)
Affinity DataIC50: 230nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50507705(CHEMBL4436132)
Affinity DataIC50: 276nMAssay Description:Inhibition of desthiobiotin-ATP acylphosphate probe binding to A-Raf in human A375 cells by MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D](Homo sapiens (Human))
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM745520(US12319655, Example 6)
Affinity DataIC50: 300nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/25/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D](Homo sapiens (Human))
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM745584(US12319655, Example 62)
Affinity DataIC50: 300nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/25/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D](Homo sapiens (Human))
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM745614(US12319655, Example 92)
Affinity DataIC50: 300nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/25/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D](Homo sapiens (Human))
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM745619(US12319655, Example 98)
Affinity DataIC50: 300nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/25/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D](Homo sapiens (Human))
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM745664(US12319655, Example 144)
Affinity DataIC50: 300nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/25/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D](Homo sapiens (Human))
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM745670(US12319655, Example 150)
Affinity DataIC50: 300nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/25/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D](Homo sapiens (Human))
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM745671(US12319655, Example 151)
Affinity DataIC50: 300nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/25/2025
Entry Details
Go to US Patent

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