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TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398032(CHEMBL1603014)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity at wild type recombinant NT-495 labelled GAA incubated for 15 mins by microscale thermophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398020(CHEMBL2181103)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity at wild type recombinant NT-495 labelled GAA incubated for 15 mins by microscale thermophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50283602(6a-Hydroxymethyl-2-phenylamino-4,5,6,6a-tetrahydro...)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity was determined against baker's yeast Alpha-GlucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 60nMAssay Description:Inhibition of maltase in human Caco-2 cell model system after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50263044(Voglibose | CHEMBL476960)
Affinity DataIC50: 70nMAssay Description:Inhibition of maltase in human Caco-2 cell model system after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM18355(N-Butyl-DNJ | (2R,3R,4R,5S)-1-butyl-2-(hydroxymeth...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human lysosomal alpha glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM18355(N-Butyl-DNJ | (2R,3R,4R,5S)-1-butyl-2-(hydroxymeth...)
Affinity DataIC50: 100nMAssay Description:Inhibition of lysosomal alpha-glucosidase by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50259956(2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | alp...)
Affinity DataIC50: 100nMAssay Description:Inhibition of maltase in human Caco-2 cell model system after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM628474(US20230339856, Compound (IId))
Affinity DataIC50: 150nMAssay Description:The rhGAA enzyme sold under the name Myozyme used comes from residues of perfusions of the recombinant enzyme used for treating, by enzyme therapy, t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent

TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM628473(US20230339856, Compound (IIc))
Affinity DataIC50: 220nMAssay Description:The rhGAA enzyme sold under the name Myozyme used comes from residues of perfusions of the recombinant enzyme used for treating, by enzyme therapy, t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent

TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50617171(CHEMBL5429566)
Affinity DataIC50: 250nMAssay Description:Inhibition of human lysosomal alpha-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50478556(CORTICATIC ACID A)
Affinity DataIC50: 344nMAssay Description:Inhibition of alpha-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 350nMAssay Description:Inhibition of human lysosomal alpha-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50583379(CHEMBL5028138 | US20230339856, Compound (IIb))
Affinity DataIC50: 390nMAssay Description:The rhGAA enzyme sold under the name Myozyme used comes from residues of perfusions of the recombinant enzyme used for treating, by enzyme therapy, t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent

TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50299749((2R,3R,4R,5S)-1-[5-(Adamantan-1-ylmethoxy)-pentyl]...)
Affinity DataIC50: 400nMAssay Description:Inhibition of human lysosomal alpha glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50299749((2R,3R,4R,5S)-1-[5-(Adamantan-1-ylmethoxy)-pentyl]...)
Affinity DataIC50: 400nMAssay Description:Inhibition of lysosomal alpha-glucosidase by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 410nMAssay Description:The rhGAA enzyme sold under the name Myozyme used comes from residues of perfusions of the recombinant enzyme used for treating, by enzyme therapy, t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent

TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50583378(CHEMBL5028084 | US20230339856, Compound (IIa))
Affinity DataIC50: 420nMAssay Description:The rhGAA enzyme sold under the name Myozyme used comes from residues of perfusions of the recombinant enzyme used for treating, by enzyme therapy, t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent

TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50124581(CHEMBL3621529 | US20230339856, Compound (IIg))
Affinity DataIC50: 460nMAssay Description:The rhGAA enzyme sold under the name Myozyme used comes from residues of perfusions of the recombinant enzyme used for treating, by enzyme therapy, t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent

TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50312529(N-[5-(Adamantan-1-yl-methoxy)-pentyl]-D-galacto-1-...)
Affinity DataIC50: 500nMAssay Description:Inhibition of lysosomal alpha-glucosidase by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50478555(Callyspongynic Acid)
Affinity DataIC50: 531nMAssay Description:Inhibition of alpha-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM18363((2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-octylpiperidi...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human lysosomal alpha-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50596693(CHEMBL5189075)
Affinity DataIC50: 630nMAssay Description:Inhibition of human lysosomal alpha glucosidase assessed as release of p-nitrophenol using p-nitrophenyl glycoside as substrate by spectrometric assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398032(CHEMBL1603014)
Affinity DataIC50: 750nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using blue-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM628475(US20230339856, Compound (IIf))
Affinity DataIC50: 870nMAssay Description:The rhGAA enzyme sold under the name Myozyme used comes from residues of perfusions of the recombinant enzyme used for treating, by enzyme therapy, t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent

TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398032(CHEMBL1603014)
Affinity DataIC50: 940nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using red-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50283602(6a-Hydroxymethyl-2-phenylamino-4,5,6,6a-tetrahydro...)
Affinity DataIC50: 999nMAssay Description:Inhibitory activity was determined against baker's yeast Alpha-GlucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50283602(6a-Hydroxymethyl-2-phenylamino-4,5,6,6a-tetrahydro...)
Affinity DataIC50: 999nMAssay Description:Inhibitory activity was determined against baker's yeast Alpha-GlucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human lysosomal alpha-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50259956(2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | alp...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human lysosomal alpha-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of maltase in human Caco-2 cell model system after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398022(CHEMBL2181097)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using blue-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50283598(5-Amino-1-hydroxymethyl-cyclopentane-1,2,3,4-tetra...)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibitory activity against baker's yeast Alpha-galactosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398022(CHEMBL2181097)
Affinity DataIC50: 1.46E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using red-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human lysosomal alpha glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of lysosomal alpha-glucosidase by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50312528(N-Butyl-D-galacto-1-deoxynojirimycin | CHEMBL10869...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of lysosomal alpha-glucosidase by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398020(CHEMBL2181103)
Affinity DataIC50: 1.63E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using blue-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398020(CHEMBL2181103)
Affinity DataIC50: 1.63E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using red-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398029(CHEMBL2180814)
Affinity DataIC50: 1.88E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using blue-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of lysosomal alpha-glucosidase by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50333458((2S,3S,4S,5S)-2-heptyl-5-(hydroxymethyl)pyrrolidin...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human lysosomal acid alpha-glucosidase incubated for 30 mins by fluorescence based spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50104671(CHEMBL3593568)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of alpha-glucosidase (unknown origin) pre-incubated for 20 mins before p-nitrophenyl glycoside substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50283603(4-Hydroxymethyl-2-phenylamino-4,5,6,6a-tetrahydro-...)
Affinity DataIC50: 2.32E+3nMAssay Description:Inhibitory activity was determined against baker's yeast Alpha-GlucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398029(CHEMBL2180814)
Affinity DataIC50: 2.37E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using red-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50596691(CHEMBL5198563)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human lysosomal alpha glucosidase assessed as release of p-nitrophenol using p-nitrophenyl glycoside as substrate by spectrometric assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50375511(CHEMBL406973)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human lysosomal acid alpha-glucosidase incubated for 30 mins by fluorescence based spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398028(CHEMBL2180816)
Affinity DataIC50: 2.91E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using blue-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50283604(6-Hydroxymethyl-2-phenylamino-4,5,6,6a-tetrahydro-...)
Affinity DataIC50: 2.93E+3nMAssay Description:Inhibitory activity was determined against baker's yeast Alpha-GlucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398028(CHEMBL2180816)
Affinity DataIC50: 3.26E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using red-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
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