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TargetReplicase polyprotein 1ab(PEDV)
Purdue Research Foundation

US Patent
LigandPNGBDBM420996(US9975885, Compound 77)
Affinity DataIC50: 500nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
9/25/2020
Entry Details
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TargetReplicase polyprotein 1ab(PEDV)
Purdue Research Foundation

US Patent
LigandPNGBDBM420993(US9975885, Compound 47)
Affinity DataIC50: 700nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
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TargetReplicase polyprotein 1ab(PEDV)
Purdue Research Foundation

US Patent
LigandPNGBDBM420991(US9975885, Compound 44)
Affinity DataIC50: 1.40E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
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TargetReplicase polyprotein 1ab(PEDV)
Purdue Research Foundation

US Patent
LigandPNGBDBM420990(US9975885, Compound 43)
Affinity DataIC50: 1.60E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
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TargetReplicase polyprotein 1ab(PEDV)
Purdue Research Foundation

US Patent
LigandPNGBDBM420994(US9975885, Compound 48)
Affinity DataIC50: 3.40E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
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TargetReplicase polyprotein 1ab(PEDV)
Purdue Research Foundation

US Patent
LigandPNGBDBM420983(med.21724, Compound 125 | US9975885, Compound 3P)
Affinity DataIC50: 3.80E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
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TargetReplicase polyprotein 1ab(PEDV)
Purdue Research Foundation

US Patent
LigandPNGBDBM420992(US9975885, Compound 46)
Affinity DataIC50: 4.30E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
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TargetReplicase polyprotein 1ab(PEDV)
Purdue Research Foundation

US Patent
LigandPNGBDBM420349(US9975885, Compound 6)
Affinity DataIC50: 8.30E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
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TargetReplicase polyprotein 1ab(PEDV)
Purdue Research Foundation

US Patent
LigandPNGBDBM420981(US9975885, Compound 64)
Affinity DataIC50: 8.70E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
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TargetReplicase polyprotein 1ab(PEDV)
Purdue Research Foundation

US Patent
LigandPNGBDBM420988(US9975885, Compound 41)
Affinity DataIC50: 1.05E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
9/25/2020
Entry Details
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TargetReplicase polyprotein 1ab(PEDV)
Purdue Research Foundation

US Patent
LigandPNGBDBM420987(US9975885, Compound 40)
Affinity DataIC50: 1.12E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
9/25/2020
Entry Details
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TargetReplicase polyprotein 1ab(PEDV)
Purdue Research Foundation

US Patent
LigandPNGBDBM420985(US9975885, Compound 38)
Affinity DataIC50: 1.55E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
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TargetReplicase polyprotein 1ab(PEDV)
Purdue Research Foundation

US Patent
LigandPNGBDBM420986(US9975885, Compound 39)
Affinity DataIC50: 1.76E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
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TargetReplicase polyprotein 1ab(PEDV)
Purdue Research Foundation

US Patent
LigandPNGBDBM420989(US9975885, Compound 42)
Affinity DataIC50: 2.62E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
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TargetReplicase polyprotein 1ab(PEDV)
Purdue Research Foundation

US Patent
LigandPNGBDBM420298(WO2005113580-Ex-02 | PF-00835231 | PF-0835231 | cm...)
Affinity DataKi:  0.300nMAssay Description:PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(PEDV)
Purdue Research Foundation

US Patent
LigandPNGBDBM420298(WO2005113580-Ex-02 | PF-00835231 | PF-0835231 | cm...)
Affinity DataKi:  0.300nMAssay Description:Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details
WIPO WO2021205298