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TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193802(US9670209, Compound 312 1-((R)-3-(3-(cyclopropylme...)
Affinity DataEC50:  32nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193784(US9670209, Compound 302 1-((R)-3-((1R,3R,5S)-3-(cy...)
Affinity DataEC50:  25nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193785(US9670209, Compound 303 1-((R)-3-((1R,3R,5S)-3-(2-...)
Affinity DataEC50:  79nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193787(US9670209, Compound 304 1-((R)-3-(3-(Cyclopropylme...)
Affinity DataEC50:  25nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193788(US9670209, Compound 305 1-((R)-3-((1R,3R,5S)-3-(Al...)
Affinity DataEC50:  130nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193789(US9670209, Compound 307 1-((R)-3-(3-(Cyclopropylme...)
Affinity DataEC50:  20nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193790(US9670209, Compound 308 1-((R)-3-(3-(Allyloxy)-8-a...)
Affinity DataEC50:  40nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193791(US9670209, Compound 309 1-((R)-3-(3-(2-Methoxyethy...)
Affinity DataEC50:  32nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193800(US9670209, Compound 311 1-((R)-3-(3-(cyclopropylme...)
Affinity DataEC50:  130nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193803(US9670209, Compound 313 1-((R)-3-((1R,3R,58)-3-(2-...)
Affinity DataEC50:  50nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193804(US9670209, Compound 314 1-((R)-3-((1R,3R,58)-3-(cy...)
Affinity DataEC50:  50nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193805(US9670209, Compound 315 1-((R)-3-(3-(cyclobutylmet...)
Affinity DataEC50:  50nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193806(US9670209, Compound 316 1-((R)-3-(3-(cyclopropylme...)
Affinity DataEC50:  250nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193807(US9670209, Compound 317 1-((R)-3-(3-(cyclopropylme...)
Affinity DataEC50:  130nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193808(US9670209, Compound 318 1-((R)-3-((1R,3R,5S)-3-(pr...)
Affinity DataEC50:  63nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193815(US9670209, Compound 319 1-((R)-3-(3-(propoxy)-8-az...)
Affinity DataEC50:  32nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193818(US9670209, Compound 320 1-((R)-3-((1R,3R,58)-3-(2-...)
Affinity DataEC50:  63nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193819(US9670209, Compound 321 1-((R)-3-(3-(cyclopropylme...)
Affinity DataEC50:  7.90nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193820(US9670209, Compound 322 1-((R)-3-((1R,3R,5S)-3-(pr...)
Affinity DataEC50:  79nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193823(US9670209, Compound 323 1-((R)-3-((1R,3R,5S)-3-(2-...)
Affinity DataEC50:  16nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193825(US9670209, Compound 324 1-((R)-3-((1R,3R,5S)-3-(2-...)
Affinity DataEC50:  13nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193787(US9670209, Compound 304 1-((R)-3-(3-(Cyclopropylme...)
Affinity DataEC50:  25nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193788(US9670209, Compound 305 1-((R)-3-((1R,3R,5S)-3-(Al...)
Affinity DataEC50:  130nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | VEMURAFENIB | US...)
Affinity DataEC50:  1.60E+3nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193834(US9670209, Comparative compound 2)
Affinity DataEC50:  79nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM43819(ethyl 4-[2-(thiophen-2-ylcarbonylamino)ethylamino]...)
Affinity DataEC50:  4.89E+4nMAssay Description:Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Grant Title: Discovery of novel allosteric modulators of the M1 mus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM43820(4-[2-[[(2-chlorophenyl)-oxomethyl]amino]ethylamino...)
Affinity DataEC50:  9.24E+4nMAssay Description:Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Grant Title: Discovery of novel allosteric modulators of the M1 mus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM43821(4-(2-benzamidoethylamino)-1-piperidinecarboxylic a...)
Affinity DataEC50:  2.80E+4nMAssay Description:Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Grant Title: Discovery of novel allosteric modulators of the M1 mus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM43822(ethyl 4-[2-[(2-methylbenzoyl)amino]ethylamino]pipe...)
Affinity DataEC50:  9.57E+4nMAssay Description:Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Grant Title: Discovery of novel allosteric modulators of the M1 mus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM50079583(WAY-132983 | (R)-3-(3-Hexylsulfanyl-pyrazin-2-ylox...)
Affinity DataEC50:  8nMAssay Description:In vitro functional agonism against M2 muscarinic receptor (cAMP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM50005363(3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bicyclo[2...)
Affinity DataEC50:  19nMAssay Description:In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM50005364(CHEMBL171721 | (3S,4R)3-Methyl-3-(3-methyl-[1,2,4]...)
Affinity DataEC50:  14nMAssay Description:In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM50072227((1R,5R,6R)-6-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]t...)
Affinity DataEC50:  9nMAssay Description:Stimulation of cAMP in CHO cells expressing human m2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
LigandPNGBDBM50229048(CHEMBL349844)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229049(CHEMBL351934)
Affinity DataEC50:  100nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229050(CHEMBL422710)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229054(CHEMBL161748)
Affinity DataEC50:  1.28E+3nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229057(CHEMBL161419)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229059(CHEMBL159708)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229053(CHEMBL161364)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229052(CHEMBL159651)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229051(CHEMBL159935)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229064(CHEMBL159839)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229055(CHEMBL161670)
Affinity DataEC50:  1.46E+3nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50046728(1-Methyl-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-1,2,3,...)
Affinity DataEC50:  32nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50229058(CHEMBL161088)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2019
Entry Details Article
PubMed
LigandPNGBDBM50228565(CHEMBL108557)
Affinity DataKd:  7.00E+3nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228566(CHEMBL2092932)
Affinity DataKd:  3.23E+3nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228567(CHEMBL2092931)
Affinity DataKd:  7.85E+3nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50228568(CHEMBL322126)
Affinity DataKd:  1.60E+4nMAssay Description:Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2019
Entry Details Article
PubMed
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