Compile Data Set for Download or QSAR
Report error Found 268 of affinity data for UniProtKB/TrEMBL: P05091
TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50557070(CHEMBL4755465)
Affinity DataEC50:  1.79E+4nMAssay Description:Allosteric activation of recombinant human full-length ALDH2 (18 to 517 residues) expressed in Escherichia coli using acetaldehyde as substrate measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50557071(CHEMBL465952)
Affinity DataEC50:  4.30E+3nMAssay Description:Allosteric activation of recombinant human full-length ALDH2 (18 to 517 residues) expressed in Escherichia coli using acetaldehyde as substrate measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM78304(2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphe...)
Affinity DataEC50:  5.79E+4nMAssay Description:Agonist activity at human recombinant ALDH2 measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118233(US8673966, tert-butyl (1-(3-((3-(4-(methylsulfonam...)
Affinity DataIC50: 2.30nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50093535(11-[3-(4-Hydroxy-phenyl)-4-oxo-4H-chromen-7-yloxy]...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Hamster Liver mitochondrial ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118229(US8673966, N-(4-(7-((1-(cyclobutanecarbonyl)azetid...)
Affinity DataIC50: 4nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50093537(10-(3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yloxy)d...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Hamster Liver mitochondrial ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118196(US8673966, N-(4-(7-((1-methyl-1H-imidazol-5-yl)eth...)
Affinity DataIC50: 4.90nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118209(US8673966, N-(4-(7-((1-(cyclopropanecarbonyl)azeti...)
Affinity DataIC50: 5nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118223(US8673966, N-(4-(7-((1-(3-hydroxy-3-methylcyclobut...)
Affinity DataIC50: 5nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118228(US8673966, N-(4-(7-((1-(2,2-difluorocyclopropane- ...)
Affinity DataIC50: 5nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118232(US8673966, tert-butyl 1-(3-((3-(4- (methylsulfonam...)
Affinity DataIC50: 5nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118220(US8673966, N-(4-(7-((1-(3,3-difluorocyclobutanecar...)
Affinity DataIC50: 6nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118225(US8673966, N-(4-(7-((1-(3-methyloxetane-3- carbony...)
Affinity DataIC50: 6nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118230(US8673966, N-(4-(7-((1-(1-methylcyclopropanecarbon...)
Affinity DataIC50: 6nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118231(US8673966, tert-butyl 1-(3-((3-(4-(methylsulfonami...)
Affinity DataIC50: 6nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118211(US8673966, N-(4-(7-((1-(cyclopropanecarbonyl)piper...)
Affinity DataIC50: 6.5nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118213(US8673966, N-(4-(7-((1-isopropyl-1H-imidazol-5- yl...)
Affinity DataIC50: 7nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118219(US8673966, N-(4-(7-((1-(3-methoxypropanoyl)azetidi...)
Affinity DataIC50: 8nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118207(US8673966, tert-butyl 3-((3-(4-(methylsulfonamido)...)
Affinity DataIC50: 9nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118208(US8673966, N-(4-(4-oxo-7-((2-oxo-1,2-dihydropyridi...)
Affinity DataIC50: 9nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118216(US8673966, cyclopentyl 3-((3-(4- (methylsulfonamid...)
Affinity DataIC50: 9nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50093534(7-[3-(4-Hydroxy-phenyl)-4-oxo-4H-chromen-7-yloxy]-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of Hamster Liver mitochondrial ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50093531(6-[3-(4-Hydroxy-phenyl)-4-oxo-4H-chromen-7-yloxy]-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of Hamster Liver mitochondrial ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118212(US8673966, N-(4-(7-((1,2-dimethyl-1H-imidazol-5- y...)
Affinity DataIC50: 15nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118222(US8673966, N-(4-(7-((1-(2-hydroxyacetyl)azetidin-3...)
Affinity DataIC50: 15nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118226(US8673966, N-(4-(7-((1-(2-hydroxypropanoyl)azetidi...)
Affinity DataIC50: 15nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118224(US8673966, N-(4-(7-((1-(2-hydroxy-2-methylpropanoy...)
Affinity DataIC50: 16nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118203(US8673966, N-(4-(4-oxo-7-(pyridin-3-ylethynyl)-4H-...)
Affinity DataIC50: 21nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM153687(US9000015, 4 | US10507215, Compound 4)
Affinity DataIC50: 23nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM153690(US9000015, 7 | US9610299, Example 7 | US10507215, ...)
Affinity DataIC50: 23nMAssay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM153687(US9000015, 4 | US10507215, Compound 4)
Affinity DataIC50: 23nMAssay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM153696(US9000015, 13 | US9610299, Example 13 | US10507215...)
Affinity DataIC50: 25nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM153696(US9000015, 13 | US9610299, Example 13 | US10507215...)
Affinity DataIC50: 25nMAssay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM153696(US9000015, 13 | US9610299, Example 13 | US10507215...)
Affinity DataIC50: 25nMAssay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118227(US8673966, N-(4-(7-((1-(1-methylpiperidine-4- carb...)
Affinity DataIC50: 35nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50093538(7-Ethoxy-3-(4-hydroxy-phenyl)-chromen-4-one | 7-et...)
Affinity DataIC50: 40nMAssay Description:Inhibition of Hamster Liver mitochondrial ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50093535(11-[3-(4-Hydroxy-phenyl)-4-oxo-4H-chromen-7-yloxy]...)
Affinity DataIC50: 40nMAssay Description:Inhibition of hamster liver aldehyde dehydrogenase ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50104892(8-(3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yloxy)oc...)
Affinity DataIC50: 40nMAssay Description:Inhibition of hamster liver aldehyde dehydrogenase ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50104896(7-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-3-(4-hydro...)
Affinity DataIC50: 40nMAssay Description:Inhibition of hamster liver aldehyde dehydrogenase ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50409029(DAIDZIN)
Affinity DataIC50: 40nMAssay Description:Inhibition of Hamster Liver mitochondrial ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118217(US8673966, N-(4-(4-oxo-7-((tetrahydro-2H-pyran-4- ...)
Affinity DataIC50: 43nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118197(US8673966, N-(4-(7-(3-methoxyprop-1-ynyl)-4-oxo-4H...)
Affinity DataIC50: 47nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50093537(10-(3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yloxy)d...)
Affinity DataIC50: 50nMAssay Description:Inhibition of hamster liver aldehyde dehydrogenase ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50093534(7-[3-(4-Hydroxy-phenyl)-4-oxo-4H-chromen-7-yloxy]-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of hamster liver aldehyde dehydrogenase ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50448802(CHEMBL3128207)
Affinity DataIC50: 50nMAssay Description:Inhibition of human ALDH2 using propionaldehyde as substrate preincubated for 2 mins followed by substrate addition by spectrophotometry in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118202(US8673966, N-(4-(4-oxo-7-(pyrimidin-5-ylethynyl)-4...)
Affinity DataIC50: 57nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM118193(US8673966, N-(4-(7-(cyclopropylethynyl)-4-oxo-4H- ...)
Affinity DataIC50: 57.7nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50093531(6-[3-(4-Hydroxy-phenyl)-4-oxo-4H-chromen-7-yloxy]-...)
Affinity DataIC50: 60nMAssay Description:Inhibition of hamster liver aldehyde dehydrogenase ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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