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TargetCalpain small subunit 1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  1.13E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50179750((S)-2-((S)-2-(benzyloxycarbonyl)-4-methylpentanami...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of isolated human calpain1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50179749((S)-2-(2-(2-(10H-phenothiazin-2-yloxy)acetamido)ac...)
Affinity DataIC50: 8nMAssay Description:Inhibition of isolated human calpain1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50286446({(S)-1-[(S)-1-(4-Hydroxy-benzyl)-2-oxo-ethylcarbam...)
Affinity DataIC50: 20nMAssay Description:Inhibition of Calpain 1 by [3H]acetyl-casein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50179745((S)-2-((S)-2-(2-(10H-phenothiazin-2-yloxy)acetamid...)
Affinity DataIC50: 25nMAssay Description:Inhibition of isolated human calpain1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50286452({(S)-1-[(S)-1-(4-Hydroxy-benzyl)-2-oxo-ethylcarbam...)
Affinity DataIC50: 25nMAssay Description:Inhibition of Calpain 1 by [3H]acetyl-casein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50286449({(S)-1-[(S)-1-(4-Methoxy-benzyl)-2-oxo-ethylcarbam...)
Affinity DataIC50: 30nMAssay Description:Inhibition of Calpain 1 by [3H]acetyl-casein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50137397([(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-3-methy...)
Affinity DataIC50: 35nMAssay Description:Inhibition of Calpain 1 by [3H]acetyl-casein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50179747((S)-2-((2S,3S)-2-(2-(10H-phenothiazin-2-yloxy)acet...)
Affinity DataIC50: 38nMAssay Description:Inhibition of isolated human calpain1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50014577(CHEMBL286722 | benzyl (S)-3-methyl-1-oxo-1-((S)-1-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of Calpain 1 by [3H]acetyl-casein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50073850([(S)-1-(1-Benzyl-2-oxo-ethylcarbamoyl)-2-methyl-pr...)
Affinity DataIC50: 40nMAssay Description:Inhibition of Calpain 1 by [3H]acetyl-casein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50179743((S)-2-((S)-2-(2-(10H-phenothiazin-2-yloxy)acetamid...)
Affinity DataIC50: 48.7nMAssay Description:Inhibition of isolated human calpain1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50286453({(S)-1-[(S)-1-(4-Hydroxy-benzyl)-2-oxo-ethylcarbam...)
Affinity DataIC50: 55nMAssay Description:Inhibition of Calpain 1 by [3H]acetyl-casein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50179744((S)-4-Methyl-2-[(S)-4-methyl-2-(2-10H-phenothiazin...)
Affinity DataIC50: 55.4nMAssay Description:Inhibition of isolated human calpain1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50179741((S)-2-((S)-2-(2-(10H-phenothiazin-2-yloxy)acetamid...)
Affinity DataIC50: 75.9nMAssay Description:Inhibition of isolated human calpain1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50179738(N-((S)-1-((S)-1-((3S)-2-hydroxy-tetrahydrofuran-3-...)
Affinity DataIC50: 85.5nMAssay Description:Inhibition of isolated human calpain1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50179746((S)-2-((S)-2-(2-(10H-phenothiazin-2-yloxy)acetamid...)
Affinity DataIC50: 88.6nMAssay Description:Inhibition of isolated human calpain1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50286445([((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-phenyl-methyl...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Calpain 1 by [3H]acetyl-casein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50286454([(S)-1-((S)-1-Formyl-2-naphthalen-1-yl-ethylcarbam...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Calpain 1 by [3H]acetyl-casein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50286455([(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-3,3-dim...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Calpain 1 by [3H]acetyl-casein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50286444([(S)-1-((S)-1-Formyl-3-phenyl-propylcarbamoyl)-2-m...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Calpain 1 by [3H]acetyl-casein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50179739((S)-4-Methyl-2-{(S)-4-methyl-2-[2-(10H-phenothiazi...)
Affinity DataIC50: 105nMAssay Description:Inhibition of isolated human calpain1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50179754((S)-2-(2-(2-(10H-phenothiazin-2-yloxy)acetamido)-2...)
Affinity DataIC50: 138nMAssay Description:Inhibition of isolated human calpain1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50286443([(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-ethyl]-...)
Affinity DataIC50: 140nMAssay Description:Inhibition of Calpain 1 by [3H]acetyl-casein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50179748((S)-4-methyl-2-[(S)-4-methyl-2-(3-10H-phenothiazin...)
Affinity DataIC50: 150nMAssay Description:Inhibition of isolated human calpain1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50179753((S)-4-Methyl-2-{(S)-2-[2-(10H-phenothiazin-2-yloxy...)
Affinity DataIC50: 151nMAssay Description:Inhibition of isolated human calpain1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50179740((S)-2-((S)-2-(2-(10H-phenothiazin-2-yloxy)acetamid...)
Affinity DataIC50: 222nMAssay Description:Inhibition of isolated human calpain1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50286456([(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-3-pheny...)
Affinity DataIC50: 270nMAssay Description:Inhibition of Calpain 1 by [3H]acetyl-casein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50179751((S)-2-((S)-2-(2-(10H-phenothiazin-2-yloxy)acetamid...)
Affinity DataIC50: 354nMAssay Description:Inhibition of isolated human calpain1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50286450([(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-2-pheny...)
Affinity DataIC50: 400nMAssay Description:Inhibition of Calpain 1 by [3H]acetyl-casein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50286451([1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-2,2-dimethy...)
Affinity DataIC50: 500nMAssay Description:Inhibition of Calpain 1 by [3H]acetyl-casein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50179752((S)-2-((R)-2-(2-(10H-phenothiazin-2-yloxy)acetamid...)
Affinity DataIC50: 553nMAssay Description:Inhibition of isolated human calpain1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50179742((3S)-3-((S)-4-methyl-2-((S)-4-methyl-2-(10H-phenot...)
Affinity DataIC50: 905nMAssay Description:Inhibition of isolated human calpain1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50286448([(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-2-napht...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Calpain 1 by [3H]acetyl-casein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50286447([1-(2-Formyl-pyrrolidine-1-carbonyl)-2-methyl-prop...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Calpain 1 by [3H]acetyl-casein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50069792((2S)-2-[(2S)-2-acetamido-4-methylpentanamido]-N-[(...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibitory activity against Calpain IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50042397(3-(2-Benzyloxycarbonylamino-4-methyl-pentanoylamin...)
Affinity DataKi:  8.5nMAssay Description:Inhibitory activity of alpha-keto esters towards calpain 1 at pH 8.0.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50042411([1-(1-Benzyl-2-oxo-2-phenethylcarbamoyl-ethylcarba...)
Affinity DataKi:  52nMAssay Description:Inhibitory activity of alpha-keto esters towards calpain 1 at pH 8.0.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50042398([1-(1-Aminooxalyl-butylcarbamoyl)-3-methyl-butyl]-...)
Affinity DataKi:  69nMAssay Description:Inhibitory activity of alpha-keto esters towards calpain 1 at pH 8.0.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50042387(3-(2-Benzyloxycarbonylamino-4-methyl-pentanoylamin...)
Affinity DataKi:  75nMAssay Description:Inhibitory activity of alpha-keto esters towards calpain 1 at pH 8.0.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50042396([1-(1-Benzyl-2-isobutylcarbamoyl-2-oxo-ethylcarbam...)
Affinity DataKi:  80nMAssay Description:Inhibitory activity of alpha-keto esters towards calpain 1 at pH 8.0.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50042399([1-(1-Heptylaminooxalyl-propylcarbamoyl)-3-methyl-...)
Affinity DataKi:  96nMAssay Description:Inhibitory activity of alpha-keto esters towards calpain 1 at pH 8.0.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50042421(3-(2-Diphenylacetylamino-4-methyl-pentanoylamino)-...)
Affinity DataKi:  100nMAssay Description:Inhibitory activity of alpha-keto esters towards calpain 1 at pH 8.0.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50042405([3-Methyl-1-(1-nonylaminooxalyl-propylcarbamoyl)-b...)
Affinity DataKi:  120nMAssay Description:Inhibitory activity of alpha-keto esters towards calpain 1 at pH 8.0.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50042425({1-[1-(2,2-Diphenyl-ethylaminooxalyl)-propylcarbam...)
Affinity DataKi:  160nMAssay Description:Inhibitory activity of alpha-keto esters towards calpain 1 at pH 8.0.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50042395([3-Methyl-1-(1-phenethylaminooxalyl-propylcarbamoy...)
Affinity DataKi:  200nMAssay Description:Inhibitory activity of alpha-keto esters towards calpain 1 at pH 8.0.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50042415([1-(1-Butylaminooxalyl-propylcarbamoyl)-3-methyl-b...)
Affinity DataKi:  200nMAssay Description:Inhibitory activity of alpha-keto esters towards calpain 1 at pH 8.0.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50042427([1-(1-Benzylaminooxalyl-propylcarbamoyl)-3-methyl-...)
Affinity DataKi:  200nMAssay Description:Inhibitory activity of alpha-keto esters towards calpain 1 at pH 8.0.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50042412([1-(1-Benzyl-2-ethylcarbamoyl-2-oxo-ethylcarbamoyl...)
Affinity DataKi:  200nMAssay Description:Inhibitory activity of alpha-keto esters towards calpain 1 at pH 8.0.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50042404([1-(1-Ethylaminooxalyl-butylcarbamoyl)-3-methyl-bu...)
Affinity DataKi:  210nMAssay Description:Inhibitory activity of alpha-keto esters towards calpain 1 at pH 8.0.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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