Compile Data Set for Download or QSAR
Report error Found 27 for UniProtKB: P04584
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM1250((2S)-N-[(2S,3R)-4-[(2R)-2-tert-butyl-N-(pentan-3-y...)
Affinity DataIC50: 6.30nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM1249((2S)-N-[(2S,3R)-4-[(2R)-2-tert-butyl-N-(pentan-3-y...)
Affinity DataIC50: 6.70nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM1248((2R)-2-tert-butyl-N-[(2R,3S)-2-hydroxy-3-[(2S)-3-m...)
Affinity DataIC50: 38nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM1247((2R)-2-tert-butyl-N-[(2R,3S)-2-hydroxy-3-[(2S)-3-m...)
Affinity DataIC50: 42nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM1252((2R)-2-tert-butyl-N-[(2R,3S)-2-hydroxy-3-[(2S,3R)-...)
Affinity DataIC50: 135nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM1251((2R)-2-tert-butyl-N-[(2R,3S)-2-hydroxy-3-[(2S,3R)-...)
Affinity DataIC50: 185nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [613-1167,R896S,E946D,S1117V]/[618-1043,R896S,E946D](Human immunodeficiency virus 2)
National Cancer Institute-Bethesda

LigandPNGBDBM33045(SMR000066289 | MLS000056922 | cid_2997881 | 2-azan...)
Affinity DataIC50: 2.50E+3nMpH: 8.0 T: 2°CAssay Description:RNaseH assays were performed using an 18-nucleotide 3-fluorescein-labeled RNA annealed to a complementary 18-nucleotide 5-dabcyl conjugated DNA. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [613-1167,R896S,E946D,S1117V]/[618-1043,R896S,E946D](Human immunodeficiency virus 2)
National Cancer Institute-Bethesda

LigandPNGBDBM33963(vinylogous urea, NSC727448)
Affinity DataIC50: 5.00E+3nMpH: 8.0 T: 2°CAssay Description:RNaseH assays were performed using an 18-nucleotide 3-fluorescein-labeled RNA annealed to a complementary 18-nucleotide 5-dabcyl conjugated DNA. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [613-1167,R896S,E946D,S1117V]/[618-1043,R896S,E946D](Human immunodeficiency virus 2)
National Cancer Institute-Bethesda

LigandPNGBDBM2338(methyl 1-[(2-amino-5-chlorobenzene)sulfonyl]-1H-py...)
Affinity DataIC50: 2.00E+4nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [613-1167,R896S,E946D,S1117V]/[618-1043,R896S,E946D](Human immunodeficiency virus 2)
National Cancer Institute-Bethesda

LigandPNGBDBM2339(ethyl 1-[(2-amino-5-chlorobenzene)sulfonyl]-1H-pyr...)
Affinity DataIC50: 2.00E+4nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [613-1167,R896S,E946D,S1117V]/[618-1043,R896S,E946D](Human immunodeficiency virus 2)
National Cancer Institute-Bethesda

LigandPNGBDBM1434(BI-RG-587 | 2-cyclopropyl-7-methyl-2,4,9,15-tetraa...)
Affinity DataIC50: 2.00E+4nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM729(CHEMBL13134 | BILA 2011 BS | (2S,4R)-N-tert-butyl-...)
Affinity DataKi:  0.130nM ΔG°:  -58.7kJ/mole IC50: 10nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM517(Crixivan | CHEMBL115 | L-735, 524 | MK639 | Indina...)
Affinity DataKi:  3.32nM ΔG°:  -49.2kJ/molepH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM870(benzyl N-[(1S)-1-{[(1S,2S)-1-[(10R,13R)-9,12-dioxo...)
Affinity DataKi:  16nM ΔG°:  -46.3kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM966(benzyl N-[(1S)-1-{[(2S,3R,4R)-4-{[(1S)-1-[(1H-1,3-...)
Affinity DataKi:  17nMAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM857(benzyl N-[(1S)-1-{[(1S,2S)-1-[(10R,13R)-9,12-dioxo...)
Affinity DataKi:  19nM ΔG°:  -45.8kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM858(benzyl N-[(1S)-1-{[(1S,2S)-1-[(13R,16R)-12,15-diox...)
Affinity DataKi:  27nM ΔG°:  -44.9kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM770(4-hydroxy-6-(1-phenylbutan-2-yl)-3-(1-phenylpropyl...)
Affinity DataKi:  32nMAssay Description:HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2017
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM936(benzyl N-[(1S)-1-{[(2S,3R,4R)-4-{[(1S)-1-(benzylca...)
Affinity DataKi:  39nM ΔG°:  -44.0kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM875(benzyl N-[(1S)-1-{[(2S,3S,4R)-3-hydroxy-4-{[(1S,2S...)
Affinity DataKi:  50nM ΔG°:  -43.3kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM967(5PhBuCOOH deriv. | Tle-Val-Sta | benzyl N-[(1S)-1-...)
Affinity DataKi:  52nMAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM942(5PhBuCOOH deriv. | benzyl N-[(1S)-1-{[(2S,3R,4R)-4...)
Affinity DataKi:  54nM ΔG°:  -43.2kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM968(5PhBuCOOH deriv. | (2R,3R,4S)-N-[(1S)-1-[(1H-1,3-b...)
Affinity DataKi:  63nMAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM969(5PhBuCOOH deriv. | (2R,3R,4S)-N-[(1S)-1-[(1H-1,3-b...)
Affinity DataKi:  110nMAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM964(2-Aminobenzyl-Substituted AHPPA deriv. 1 | 5PhBuCO...)
Affinity DataKi:  120nMAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM874(benzyl N-[(1S)-1-{[(2S,3S,4R)-4-{[(1R)-1-[(1H-1,3-...)
Affinity DataKi:  120nM ΔG°:  -41.1kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM926(5PhBuCOOH deriv. | benzyl N-[(1S)-1-{[(2S,3R,4R)-4...)
Affinity DataKi:  180nM ΔG°:  -40.0kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2004
Entry Details Article
PubMed