Compile Data Set for Download or QSAR
Report error Found 357 of affinity data for UniProtKB/TrEMBL: P04035
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM20182((1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-me...)
Affinity DataEC50:  630nMAssay Description:Induction of human HMGCR-dCat-ELuc degradation expressed in HEK293 cells assessed as reduction in luciferase activity after 4 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50541163(CHEMBL4639024)
Affinity DataEC50:  470nMAssay Description:Induction of human HMGCR-dCat-ELuc degradation expressed in HEK293 cells assessed as reduction in luciferase activity after 4 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50030477(CHEBI:77317 | SR-12813 | CHEMBL458767)
Affinity DataEC50:  1.10E+3nMAssay Description:Induction of degradation of Flag-tagged human HMGCR-dCat-ELuc membrane domain (1 to 499 residues) expressed in HEK293 cells assessed as reduction in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50541163(CHEMBL4639024)
Affinity DataEC50:  876nMAssay Description:Induction of degradation of Flag-tagged human HMGCR-dCat-ELuc membrane domain (1 to 499 residues) expressed in HEK293 cells assessed as reduction in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50559939(CHEMBL4756373)
Affinity DataEC50:  153nMAssay Description:Induction of degradation of Flag-tagged human HMGCR-dCat-ELuc membrane domain (1 to 499 residues) expressed in HEK293 cells assessed as reduction in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50559940(CHEMBL4761385)
Affinity DataEC50:  417nMAssay Description:Induction of degradation of Flag-tagged human HMGCR-dCat-ELuc membrane domain (1 to 499 residues) expressed in HEK293 cells assessed as reduction in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50559941(CHEMBL4741940)
Affinity DataEC50:  1.16E+3nMAssay Description:Induction of degradation of Flag-tagged human HMGCR-dCat-ELuc membrane domain (1 to 499 residues) expressed in HEK293 cells assessed as reduction in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50559942(CHEMBL4760244)
Affinity DataEC50:  2.77E+3nMAssay Description:Induction of degradation of Flag-tagged human HMGCR-dCat-ELuc membrane domain (1 to 499 residues) expressed in HEK293 cells assessed as reduction in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50559943(CHEMBL4062898)
Affinity DataEC50:  1.34E+3nMAssay Description:Induction of degradation of Flag-tagged human HMGCR-dCat-ELuc membrane domain (1 to 499 residues) expressed in HEK293 cells assessed as reduction in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50559944(CHEMBL4800468)
Affinity DataEC50:  317nMAssay Description:Induction of degradation of Flag-tagged human HMGCR-dCat-ELuc membrane domain (1 to 499 residues) expressed in HEK293 cells assessed as reduction in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50559945(CHEMBL4764757)
Affinity DataEC50:  1.46E+3nMAssay Description:Induction of degradation of Flag-tagged human HMGCR-dCat-ELuc membrane domain (1 to 499 residues) expressed in HEK293 cells assessed as reduction in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50559946(CHEMBL4763395)
Affinity DataEC50:  3.54E+3nMAssay Description:Induction of degradation of Flag-tagged human HMGCR-dCat-ELuc membrane domain (1 to 499 residues) expressed in HEK293 cells assessed as reduction in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50559947(CHEMBL4781362)
Affinity DataEC50:  1.66E+3nMAssay Description:Induction of degradation of Flag-tagged human HMGCR-dCat-ELuc membrane domain (1 to 499 residues) expressed in HEK293 cells assessed as reduction in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50559948(CHEMBL4797059)
Affinity DataEC50:  633nMAssay Description:Induction of degradation of Flag-tagged human HMGCR-dCat-ELuc membrane domain (1 to 499 residues) expressed in HEK293 cells assessed as reduction in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50559949(CHEMBL4750834)
Affinity DataEC50:  795nMAssay Description:Induction of degradation of Flag-tagged human HMGCR-dCat-ELuc membrane domain (1 to 499 residues) expressed in HEK293 cells assessed as reduction in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610280(CHEMBL5267183)
Affinity DataEC50:  874nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610281(CHEMBL5275570)
Affinity DataEC50:  990nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610282(CHEMBL5277972)
Affinity DataEC50:  722nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610283(CHEMBL5268887)
Affinity DataEC50:  336nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610284(CHEMBL5276325)
Affinity DataEC50:  152nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610285(CHEMBL5275821)
Affinity DataEC50:  351nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610286(CHEMBL5275694)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610287(CHEMBL5276525)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610288(CHEMBL5289887)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610289(CHEMBL5282835)
Affinity DataEC50:  832nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610290(CHEMBL5271654)
Affinity DataEC50:  337nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610291(CHEMBL5290557)
Affinity DataEC50:  450nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610292(CHEMBL5288010)
Affinity DataEC50:  693nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610293(CHEMBL5266489)
Affinity DataEC50:  1.45E+3nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50559939(CHEMBL4756373)
Affinity DataEC50:  132nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610294(CHEMBL5266129)
Affinity DataEC50:  598nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610295(CHEMBL5290996)
Affinity DataEC50:  2.26E+3nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610296(CHEMBL5282672)
Affinity DataEC50:  311nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610297(CHEMBL5269334)
Affinity DataEC50:  389nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610298(CHEMBL5283544)
Affinity DataEC50:  492nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610299(CHEMBL5267256)
Affinity DataEC50:  98nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610300(CHEMBL5288099)
Affinity DataEC50:  102nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610301(CHEMBL5269782)
Affinity DataEC50:  98nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610302(CHEMBL5277572)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610303(CHEMBL5280701)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610304(CHEMBL5266062)
Affinity DataEC50:  356nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50610305(CHEMBL5284059)
Affinity DataEC50:  84nMAssay Description:Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50559942(CHEMBL4760244)
Affinity DataEC50:  1.10E+3nMAssay Description:Induction of HMGCR degradation in human HepG2 cells incubated for 3 hrs by densitometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50541163(CHEMBL4639024)
Affinity DataEC50:  880nMAssay Description:Induction of HMGCR degradation (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50013216(CHEMBL348798 | Sodium salt of7-[4-(4-Fluoro-phenyl...)
Affinity DataIC50: 0.00200nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50007261(CHEMBL102091 | Sodium; 7-[4-(4-fluoro-phenyl)-2-is...)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50013210(CHEMBL162642 | Sodium salt of 7-[4-(4-Fluoro-pheny...)
Affinity DataIC50: 0.0140nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50013217(CHEMBL159951 | Sodium salt of7-[1-Cyclohexyl-4-(4-...)
Affinity DataIC50: 0.0180nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50013212(CHEMBL160102 | Sodium salt of7-[4-(4-Fluoro-phenyl...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50004774(2-Methyl-butyric acid 8-[2-(4-hydroxy-6-oxo-tetrah...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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