Compile Data Set for Download or QSAR
Report error Found 3142 of affinity data for UniProtKB/TrEMBL: P01375
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM228654((E)-4-(2-(4-chloro-3-nitrophenyl)) (C87))
Affinity DataKd:  110nMpH: 7.0Assay Description:Surface plasmon resonance (SPR) assays were carried out on a BIAcore 3000 instrument (Biacore, Inc). Briefly, purified hTNFα was dissolved at 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50103596(CHEBI:9334 | Azulfidine | Azulfidine EN | Azulfidi...)
Affinity DataKd:  9.00E+3nMpH: 7.0Assay Description:Surface plasmon resonance (SPR) assays were carried out on a BIAcore 3000 instrument (Biacore, Inc). Briefly, purified hTNFα was dissolved at 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50356920(CHEMBL1915761)
Affinity DataKd:  17nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50021397(CHEMBL3289608)
Affinity DataKd:  1.82E+3nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50378582(NSC-407303 | APIGETRIN | Apigenin 7-O-β-D-glu...)
Affinity DataKd:  200nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50241242(cid_5280637 | Cynaroside | Cinaroside | luteolin 7...)
Affinity DataKd:  790nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50021401(CHEMBL3289609)
Affinity DataKd:  13nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50021402(Ganoderic Acid D)
Affinity DataKd:  19nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50356915(GANODERIC ACID B)
Affinity DataKd:  8nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50359040(CHEMBL1922174)
Affinity DataKd:  8nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50359037(CHEMBL602899)
Affinity DataKd:  8nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50359044(CHEMBL1922178)
Affinity DataKd:  2.45nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50021403(Ganoderic Acid F)
Affinity DataKd:  2.69nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  3.81nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  1.30E+4nMAssay Description:Binding affinity to TNFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  1.18E+4nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % MeOH as solventMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  9.77E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % MeOH as solventMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  8.30E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % MeOH as solventMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  6.18E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % PEG3350 as solventMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  5.36E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % DMSO as solventMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  8.44E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % PEG3350 as solventMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  5.75E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % PEG3350 as solventMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  7.51E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % DMF as solventMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  7.34E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % DMSO as solventMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  5.70E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % DMSO as solventMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  5.36E+3nMpH: 6.5Assay Description:Binding affinity to GST-tagged human TNF-alpha in 10 mM citrate-phosphate at pH 6.5 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407062((R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-(2-...)
Affinity DataEC50:  32nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407063(6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-((R)- 2...)
Affinity DataEC50:  9nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407064(6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N- ((1r,4...)
Affinity DataEC50:  62nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407065((R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N- (2...)
Affinity DataEC50:  33nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407066(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(6-(2- ...)
Affinity DataEC50:  207nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407067(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-(isopro...)
Affinity DataEC50:  152nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407068(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4- (isopr...)
Affinity DataEC50:  442nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407069(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-((R)-2-...)
Affinity DataEC50:  774nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407070(7-(5-(((1,1-dioxidotetra- hydrothiophen- 3-yl)meth...)
Affinity DataEC50:  5.10E+3nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407071((R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-(2-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407072((R)-4-amino-6-(3-cyano- pyrrolo[1,2-b]pyridazin-7-...)
Affinity DataEC50:  1.04E+3nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407073(N-((1r,4r)-4-aminocyclo- hexyl)-6-(3-cyano- pyrrol...)
Affinity DataEC50:  97nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407074(N-((1r,4r)-4-acetamido- cyclohexyl)-6-(3-cyano- py...)
Affinity DataEC50:  79nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407075(4-(((1R,3r,5S)-8- azabicyclo[3.2.1]octan-3- yl)ami...)
Affinity DataEC50:  626nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407076(US10336762, Compound 29 | 6-(3-cyanopyrrolo[1,2-b]...)
Affinity DataEC50:  302nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407077((R)-4-((1-acetylpiperidin- 4-yl)amino)-6-(3-cyano-...)
Affinity DataEC50:  204nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407078((R)-6-(3-(1H-tetrazol-5-yl) pyrrolo[1,2-b]pyridazi...)
Affinity DataEC50:  5.20E+3nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407079(US10336762, Compound 45 | 6-(3-cyanopyrrolo[1,2-b]...)
Affinity DataEC50:  757nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407080(7-(5-(2-(2-(hydroxy- methyl)cyclopropyl) acetyl)-4...)
Affinity DataEC50:  926nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407081(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-(isopro...)
Affinity DataEC50:  128nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407082(6-(3-cyanopyrrolo[1,2-b] pyridazin-7- yl)-4-(isopr...)
Affinity DataEC50:  69nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407083(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-(isopro...)
Affinity DataEC50:  87nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407084((R)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(2-...)
Affinity DataEC50:  676nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

LigandPNGBDBM407075(4-(((1R,3r,5S)-8- azabicyclo[3.2.1]octan-3- yl)ami...)
Affinity DataEC50:  642nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

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