Compile Data Set for Download or QSAR
Report error Found 540 of affinity data for UniProtKB/TrEMBL: P00491
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50293091(7-({[(1R,2S)-2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL...)
Affinity DataKd:  0.00860nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50293063(7-{[(1,3-Dihydroxypropan-2-yl)(2-hydroxyethyl)amin...)
Affinity DataKd:  0.469nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM92927(Immucillins, 11)
Affinity DataKd:  0.383nMAssay Description:Inhibition assay using human PNP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2013
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM92929(Immucillins, 13)
Affinity DataKd:  0.156nMAssay Description:Inhibition assay using human PNP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2013
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM92930(Immucillins, 14)
Affinity DataKd:  53nMAssay Description:Inhibition assay using human PNP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2013
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50293068(7-{[(2-Hydroxyethyl)amino]methyl}-3,5-dihydro-4H-p...)
Affinity DataKd:  1.10nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50293077(7-{[(4-Hydroxybutyl)amino]methyl}-3,5-dihydro-4H-p...)
Affinity DataKd:  25nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50293075(7-({[3-Hydroxy-2-(hydroxymethyl)propyl]amino}methy...)
Affinity DataKd:  14.1nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50293070(7-({[3-Hydroxy-2-(hydroxymethyl)propyl](methyl)ami...)
Affinity DataKd:  3.70nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50293064(Immucillins, 10 | CHEMBL523107 | 7-({[1,3-Dihydrox...)
Affinity DataKd:  0.620nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM136302(US8853224, 12 | US9290501, MT-TrisMe-ImmH)
Affinity DataKd:  3nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50293076(7-({[(2R)-2,3-Dihydroxypropyl]amino}methyl)-3,5-di...)
Affinity DataKd:  14.9nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM136303(US8853224, 3.4)
Affinity DataKd:  300nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50293079(7-({[(2S)-2,3-Dihydroxypropyl](2-hydroxyethyl)amin...)
Affinity DataKd:  165nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50293071(7-({[(2S)-2,3-Dihydroxypropyl]amino}methyl)-3,5-di...)
Affinity DataKd:  4.20nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50293081(7-({[(2R)-2,3-Dihydroxypropyl](2-hydroxyethyl)amin...)
Affinity DataKd:  96nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50293073(7-({[(2S,3S)-1,3,4-Trihydroxybutan-2-yl]amino}meth...)
Affinity DataKd:  5.20nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50293072(7-({[(2R,3R)-1,3,4-Trihydroxybutan-2-yl]amino}meth...)
Affinity DataKd:  4.30nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50293067(7-({[(2S,3R)-1,3,4-Trihydroxybutan-2-yl]amino}meth...)
Affinity DataKd:  1nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50293078(7-({[(2S,3R)-2,3,4-Trihydroxybutyl]amino}methyl)-3...)
Affinity DataKd:  31nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM136304(US8853224, 20.5)
Affinity DataKd:  84nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50293083(7-({[(2R/S)-2,4-Dihydroxybutyl](methyl)amino}methy...)
Affinity DataKd:  227nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50293085(7-({[(2R/S,3S/R)-3,4-Dihydroxy-2-(hydroxymethyl)bu...)
Affinity DataKd:  0.780nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM136305(US8853224, 22)
Affinity DataKd:  900nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM136306(US8853224, 24)
Affinity DataKd:  15nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM136307(US8853224, 25)
Affinity DataKd:  74nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM136308(US8853224, 26)
Affinity DataKd:  71nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM136309(US8853224, 27)
Affinity DataKd:  142nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM136310(US8853224, 28)
Affinity DataKd:  5.60nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM136311(US8853224, 23)
Affinity DataKd:  159nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM136312(US8853224, 29)
Affinity DataKd:  22nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM136313(US8853224, 19)
Affinity DataKd:  51nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM136314(US8853224, 20.8)
Affinity DataKd:  789nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50293060(7-{(1S)-1-[(1,3-Dihydroxypropan-2-yl)amino]-2-hydr...)
Affinity DataKd:  0.210nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
Go to US Patent

TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKd:  0.0580nMAssay Description:Binding affinity to human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM22109(CHEMBL1213653 | 7-{[(3R,4R)-3-hydroxy-4-(hydroxyme...)
Affinity DataKd:  0.00850nMAssay Description:Binding affinity to human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50330392(CHEMBL1275660 | Immucillins, 15 | 7-(pyrrolidin-1-...)
Affinity DataKd:  5.5nMAssay Description:Inhibition of human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKd:  0.0560nMAssay Description:Inhibition of human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50046227(2-Amino-6-thiophen-2-ylmethyl-3,7-dihydro-pyrrolo[...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50046231(2-Amino-6-furan-2-ylmethyl-3,7-dihydro-pyrrolo[3,2...)
Affinity DataIC50: 0.0570nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of human recombinant PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50046249(2-Amino-6-thiophen-3-ylmethyl-3,7-dihydro-pyrrolo[...)
Affinity DataIC50: 0.0670nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50046224(2-Amino-8-[(thiophen-3-ylmethyl)-amino]-1,9-dihydr...)
Affinity DataIC50: 0.0850nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50046252(2-Amino-6-benzyl-3,7-dihydro-pyrrolo[3,2-d]pyrimid...)
Affinity DataIC50: 0.0850nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50046246(2-Amino-8-[(thiophen-2-ylmethyl)-amino]-1,9-dihydr...)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50046241(2-Amino-8-[(furan-2-ylmethyl)-amino]-1,9-dihydro-p...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50046251(2-Amino-8-benzylamino-1,9-dihydro-purin-6-one | CH...)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50046221(2-Amino-6-[(thiophen-3-ylmethyl)-amino]-3,7-dihydr...)
Affinity DataIC50: 0.630nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50046216(2-Amino-6-[(furan-2-ylmethyl)-amino]-3,7-dihydro-p...)
Affinity DataIC50: 0.75nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

US Patent
LigandPNGBDBM50046223(2-Amino-6-benzylamino-3,7-dihydro-pyrrolo[3,2-d]py...)
Affinity DataIC50: 0.850nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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