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Report error Found 125 of affinity data for UniProtKB/TrEMBL: O88867
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072078(CHEMBL3407905)
Affinity DataIC50: 2nMAssay Description:Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072077(CHEMBL3407866)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072081(CHEMBL3407922)
Affinity DataIC50: 4nMAssay Description:Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072079(CHEMBL3407913)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072080(CHEMBL3407919)
Affinity DataIC50: 17nMAssay Description:Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061924(4-Amino-N-[4-(2-fluoro-5-trifluoromethyl-phenyl)-t...)
Affinity DataIC50: 19nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072083(CHEMBL3407929)
Affinity DataIC50: 20nMAssay Description:Inhibition of KMO in rat brain homogenates using kynurenine as substrate measured after 5 to 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2019
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072083(CHEMBL3407929)
Affinity DataIC50: 20nMAssay Description:Inhibition of KMO in rat brain homogenates using kynurenine as substrate measured after 5 to 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2019
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50126147(CHEMBL3629571)
Affinity DataIC50: 20nMAssay Description:Inhibition of rat liver KMO using [3,5-3H]-kynurenine substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50: 22nMAssay Description:Inhibition of Wistar rat KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50623699(CHEMBL5416308)
Affinity DataIC50: 24nMAssay Description:Inhibition of rat liver KMOMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50: 37nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50: 37nMAssay Description:Inhibition of rat kidney KMOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061922(N-[4-(2-Fluoro-5-trifluoromethyl-phenyl)-thiazol-2...)
Affinity DataIC50: 39nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061911(4-Amino-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benzen...)
Affinity DataIC50: 40nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50623698(CHEMBL5430817)
Affinity DataIC50: 40nMAssay Description:Inhibition of rat brain KMOMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50623700(CHEMBL5433358)
Affinity DataIC50: 40nMAssay Description:Inhibition of rat liver KMOMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061906(4-Methyl-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benze...)
Affinity DataIC50: 48nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061917(4-Methoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benz...)
Affinity DataIC50: 51nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061918(N-[4-(3,4-Dichloro-phenyl)-thiazol-2-yl]-4-methyl-...)
Affinity DataIC50: 56nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061923(N-[4-(4-Chloro-phenyl)-thiazol-2-yl]-4-methyl-benz...)
Affinity DataIC50: 56nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072081(CHEMBL3407922)
Affinity DataIC50: 72nMAssay Description:Inhibition of KMO in rat microglia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061909(4-Methyl-N-(4-p-tolyl-thiazol-2-yl)-benzenesulfona...)
Affinity DataIC50: 76nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061913(4-Chloro-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benze...)
Affinity DataIC50: 84nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072078(CHEMBL3407905)
Affinity DataIC50: 86nMAssay Description:Inhibition of KMO in rat microglia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072079(CHEMBL3407913)
Affinity DataIC50: 100nMAssay Description:Inhibition of KMO in rat microglia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072077(CHEMBL3407866)
Affinity DataIC50: 105nMAssay Description:Inhibition of KMO in rat microglia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061910(N-[4-(4-Hydroxy-3-methyl-phenyl)-thiazol-2-yl]-4-m...)
Affinity DataIC50: 114nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061925(3,4-Dichloro-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-b...)
Affinity DataIC50: 120nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072244(4-(3,4-Difluoro-phenyl)-2-hydroxy-4-oxo-but-2-enoi...)
Affinity DataIC50: 120nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072257(2-Benzyl-4-(3,4-dichloro-phenyl)-4-oxo-butyric aci...)
Affinity DataIC50: 180nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061912(N-[4-(3-Nitro-phenyl)-thiazol-2-yl]-benzenesulfona...)
Affinity DataIC50: 200nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061915(CHEMBL554000 | CHEMBL139909 | 2-Amino-4-(3,4-dichl...)
Affinity DataIC50: 200nMAssay Description:Inhibition of rat KMOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061915(CHEMBL554000 | CHEMBL139909 | 2-Amino-4-(3,4-dichl...)
Affinity DataIC50: 200nMAssay Description:Compound was evaluated for the inhibition of rat brain KYN 3-OHaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061915(CHEMBL554000 | CHEMBL139909 | 2-Amino-4-(3,4-dichl...)
Affinity DataIC50: 200nMAssay Description:Inhibition of rat brain KMOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061915(CHEMBL554000 | CHEMBL139909 | 2-Amino-4-(3,4-dichl...)
Affinity DataIC50: 237nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061914(N-[4-(4-Methoxy-phenyl)-thiazol-2-yl]-4-methyl-ben...)
Affinity DataIC50: 240nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50083948(4-(3-Chloro-4-fluoro-phenyl)-2-hydroxy-4-oxo-but-2...)
Affinity DataIC50: 270nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072242(4-(3,4-Dichloro-phenyl)-2-hydroxy-4-oxo-butyric ac...)
Affinity DataIC50: 300nMAssay Description:Compound was evaluated for inhibition of rat brain KYN 3-OHaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50083940(CHEMBL278763 | CHEMBL184215 | 4-(3-Chloro-phenyl)-...)
Affinity DataIC50: 320nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061915(CHEMBL554000 | CHEMBL139909 | 2-Amino-4-(3,4-dichl...)
Affinity DataIC50: 330nMAssay Description:Compound was evaluated for the inhibition of rat liver KYN 3-OHaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072248((S)-4-(3,4-Dichloro-phenyl)-2-hydroxy-4-oxo-butyri...)
Affinity DataIC50: 420nMAssay Description:Compound was evaluated for the inhibition of rat brain KYN 3-OHaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072244(4-(3,4-Difluoro-phenyl)-2-hydroxy-4-oxo-but-2-enoi...)
Affinity DataIC50: 440nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061921(CHEMBL136883 | cid_748055 | 4-Methyl-N-(4-phenyl-t...)
Affinity DataIC50: 470nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072249(4-(3-Chloro-phenyl)-2-hydroxy-4-oxo-butyric acid |...)
Affinity DataIC50: 480nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50083950((S)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric acid ...)
Affinity DataIC50: 500nMAssay Description:Tested for inhibitory activity against kynurenine 3-hydroxylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50083931(4-(3-Fluoro-phenyl)-2-hydroxy-4-oxo-but-2-enoic ac...)
Affinity DataIC50: 580nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061907(meta-nitrobenzoyl)alanine | 2-Amino-4-(3-nitro-phe...)
Affinity DataIC50: 774nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50083933(2-Amino-4-(3-chloro-4-fluoro-phenyl)-4-oxo-but-2-e...)
Affinity DataIC50: 820nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072245(4-(3,4-Dichloro-phenyl)-4-oxo-butyric acid | CHEMB...)
Affinity DataIC50: 900nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
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