TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataKd: 1.50E+3nMAssay Description:Binding affinity to recombinant PDE5 catalytic domain (unknown origin) by ITC analysisMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataKd: 1.70E+3nMAssay Description:Binding affinity to recombinant PDE5 catalytic domain (unknown origin) by ITC analysisMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataKd: 770nMAssay Description:Binding affinity to recombinant PDE5 catalytic domain (unknown origin) by ITC analysisMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataKd: 420nMAssay Description:Binding affinity to recombinant PDE5 catalytic domain (unknown origin) by ITC analysisMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataKd: 150nMAssay Description:Binding affinity to recombinant PDE5 catalytic domain (unknown origin) by ITC analysisMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 44nMAssay Description:Relaxant effect on rabbit corpus cavernosal tissue stripsMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 42nMAssay Description:Relaxant effect on rabbit corpus cavernosal tissue stripsMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 37nMAssay Description:Relaxant effect on isolated rabbit corpus cavernosumMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 44nMAssay Description:Relaxant effect on isolated rabbit corpus cavernosumMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 9.5nMAssay Description:Relaxant effect on isolated rabbit corpus cavernosumMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 130nMAssay Description:Relaxant effect on isolated rabbit corpus cavernosumMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 12nMAssay Description:Relaxant effect on isolated rabbit corpus cavernosumMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 8.70nMAssay Description:Relaxant effect on isolated rabbit corpus cavernosumMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 7.90nMAssay Description:Relaxant effect on isolated rabbit corpus cavernosumMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataKd: 82nMAssay Description:Binding affinity to recombinant human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli BL21 DE3 Rosetta2 pLysS cells asses...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataKd: 131nMAssay Description:Binding affinity to recombinant human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli BL21 DE3 Rosetta2 pLysS cells asses...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 1.00E+3nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 40nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 220nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 250nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 280nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 330nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 700nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 830nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 5.05E+3nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 6.80E+3nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 230nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 500nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 500nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 630nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 6.70E+3nMAssay Description:Inhibition of PDE5A in HEK293 cells stably transfected with cGMP biosensor assessed as increase in SNP-induced intracellular cGMP level measured afte...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 1.84E+4nMAssay Description:Inhibition of PDE5A in HEK293 cells stably transfected with cGMP biosensor assessed as increase in SNP-induced intracellular cGMP level measured afte...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 1.38E+4nMAssay Description:Inhibition of PDE5A in HEK293 cells stably transfected with cGMP biosensor assessed as increase in SNP-induced intracellular cGMP level measured afte...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 4.10E+3nMAssay Description:Inhibition of PDE5A in HEK293 cells stably transfected with cGMP biosensor assessed as increase in SNP-induced intracellular cGMP level measured afte...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataEC50: 5.81E+3nMAssay Description:Inhibition of PDE5A in HEK293 cells stably transfected with cGMP biosensor assessed as increase in SNP-induced intracellular cGMP level measured afte...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataIC50: 0.00700nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataIC50: 0.0250nMAssay Description:Inhibition of human platelets derived PDE5 using [3H]-cGMP as substrate incubated for 60 min by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataIC50: 0.0280nMpH: 7.5 T: 2°CAssay Description:A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataIC50: 0.0290nMAssay Description:Inhibition of human platelets derived PDE5 using [3H]-cGMP as substrate incubated for 60 min by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of Phosphodiesterase 5 from human plateletsMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Chinese Academy of Sciences (Cas)
Curated by ChEMBL
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
