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TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataKd:  82nMpH: 8.0 T: 2°CAssay Description:ITC experiments were performed by Auto ITC200 (Microcal) at 25 °C. ITC sample cell was filled with 10 μM PRC2 in titration buffer (25 mM HEPES p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2017
Entry Details Article
PubMed
LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataKd:  114nMpH: 8.0 T: 2°CAssay Description:ITC experiments were performed by Auto ITC200 (Microcal) at 25 °C. ITC sample cell was filled with 10 μM PRC2 in titration buffer (25 mM HEPES p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2017
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM223987(A-395 (5) | rac-(3R,4S)-1-(7-fluoro-2,3-dihydro-1H...)
Affinity DataKd:  1.5nMpH: 7.4 T: 2°CAssay Description:SPR studies were performed using a Biacore T200 (GE Health Sciences Inc.) at 20 °C. Approximately 8,400 response units (RU) of biotinylated EED was c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2017
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50096619(CHEMBL97453 | 1,8,9-Trihydroxy-3-methoxy-benzo[4,5...)
Affinity DataKd:  2.82E+3nMAssay Description:Binding affinity to EED (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241657(CHEMBL4077899)
Affinity DataKd:  200nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50587917(CHEMBL4202777)
Affinity DataKd:  4.56E+3nMAssay Description:Binding affinity to recombinant N-terminal 6His-SUMO tagged human EED (81 to 441 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241646(CHEMBL4102320)
Affinity DataKd:  43nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM223985(rac-(3R,4S)-1-(2-fluoro-6-methylbenzyl)-N,N-dimeth...)
Affinity DataKd:  6nMAssay Description:Binding affinity to His tagged human EED (77 to 441 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50096619(CHEMBL97453 | 1,8,9-Trihydroxy-3-methoxy-benzo[4,5...)
Affinity DataKd:  2.82E+3nMAssay Description:Binding affinity to EED (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241655(CHEMBL4071358)
Affinity DataKd:  1.14E+3nMAssay Description:Binding affinity to His tagged human EED (77 to 441 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50410566(CHEMBL5288775)
Affinity DataKd:  4.00E+4nMAssay Description:Binding affinity to EED (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50594939(CHEMBL5187105)
Affinity DataKd:  900nMAssay Description:Binding affinity to EED (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50644207(CHEMBL5566553)
Affinity DataKd:  3.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241656(CHEMBL4092154)
Affinity DataKd:  290nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50594945(CHEMBL5180485)
Affinity DataKd:  0.631nMAssay Description:Binding affinity to human N-terminal His-6 tagged EED expressed in Escherichia coli strain BL2(DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM223986((3R,4S)-1-[(1S)-7-fluoroindan-1-yl]-N,N-dimethyl-4...)
Affinity DataKd:  10nMAssay Description:Binding affinity to His tagged human EED (77 to 441 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241661(CHEMBL4103307)
Affinity DataKd:  2.60E+3nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241647(CHEMBL4067115)
Affinity DataKd:  3.10E+3nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50563659(CHEMBL4759335)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to EED (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50259900(CHEMBL4101947)
Affinity DataKd:  3.20E+4nMAssay Description:Binding affinity to human methionine-13Cepsilon-methyl labeled PRC2-EED (76 to 441 residues) expressed in Escherichia coli BL21 (DE3) by 2D NMR metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2020
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241662(CHEMBL4104741)
Affinity DataKd:  2nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50562610(CHEMBL4779022)
Affinity DataKd:  0.537nMAssay Description:Binding affinity to human N-terminal His-6 tagged EED expressed in Escherichia coli strain BL2(DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50282157(CHEMBL4161291)
Affinity DataKd:  1.14E+3nMAssay Description:Binding affinity to N-terminal His-tagged full length EED (unknown origin) by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50282157(CHEMBL4161291)
Affinity DataKd:  1.14E+3nMAssay Description:Binding affinity to full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50563657(CHEMBL4762963)
Affinity DataKd:  2.40E+3nMAssay Description:Binding affinity to EED (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM291687(US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to EED (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50282163(CHEMBL4171889)
Affinity DataKd:  680nMAssay Description:Binding affinity to N-terminal His-tagged full length EED (unknown origin) by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50282165(CHEMBL4168151)
Affinity DataKd:  4.80E+3nMAssay Description:Binding affinity to full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50563659(CHEMBL4759335)
Affinity DataKd:  0.5nMAssay Description:Inhibition of EED (unknown origin) assessed dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50282114(CHEMBL4160235)
Affinity DataKd:  3.00E+3nMAssay Description:Binding affinity to full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50563656(CHEMBL4754048)
Affinity DataKd:  1.20nMAssay Description:Binding affinity to EED (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241653(CHEMBL4093678)
Affinity DataKd:  1.40E+3nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50096619(CHEMBL97453 | 1,8,9-Trihydroxy-3-methoxy-benzo[4,5...)
Affinity DataKd:  2.82E+3nMAssay Description:Binding affinity to CM5 sensor chip immobilised EED (unknown origin) assessed as dissociation constant incubated for 270 secs by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM223984(rac-(3R,4S)-1-(2-methoxybenzyl)-N,N-dimethyl-4-(1-...)
Affinity DataKd:  3.80E+4nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50035558(5-(2-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoq...)
Affinity DataKd:  1.35E+4nMAssay Description:Binding affinity to his-tagged EED (76 to 441 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50562610(CHEMBL4779022)
Affinity DataKd: <1nMAssay Description:Binding affinity to human N-terminal His6-tagged/thrombin cleavage site fused/ AVI-tagged EED (1 to 441 residues) expressed in Escherichia coli BL21(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50563658(CHEMBL4748924)
Affinity DataKd:  15nMAssay Description:Binding affinity to EED (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241648(CHEMBL4072980)
Affinity DataKd:  140nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50127824(2-Pyridin-4-yl-1,2,3,4-tetrahydro-isoquinoline | C...)
Affinity DataKd:  2.20E+4nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50562610(CHEMBL4779022)
Affinity DataKd:  1nMAssay Description:Binding affinity to EED (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241649(CHEMBL4093134)
Affinity DataKd:  9.80E+3nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50235631(CHEMBL4060827)
Affinity DataKd:  2.10E+3nMAssay Description:Binding affinity to His tagged human EED (77 to 441 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50070942((-)-Epigallocatechin-3-o-gallate | (-)-Epigallocat...)
Affinity DataKd:  1.51E+4nMAssay Description:Binding affinity to EED (unknown origin) assessed as dissociation constant SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50410555(CHEMBL5277974)
Affinity DataKd:  8.82E+3nMAssay Description:Binding affinity to N-terminal His-tagged full length EED (unknown origin) expressed in Rosetta2 BL21 (DE3) pLysS competent cells assessed as dissoci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50616331(CHEMBL5416457)
Affinity DataKd:  4.40nMAssay Description:Binding affinity to recombinant human N-terminal GST tagged EED (1 to 441 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241658(CHEMBL4064198)
Affinity DataKd:  2.50E+3nMAssay Description:Binding affinity to His tagged human EED (77 to 441 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50096619(CHEMBL97453 | 1,8,9-Trihydroxy-3-methoxy-benzo[4,5...)
Affinity DataKd:  2.80E+3nMAssay Description:Binding affinity to EED (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241645(CHEMBL4078052)
Affinity DataKd:  210nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataKd:  82nMAssay Description:Binding affinity to EED (unknown origin) by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50282164(CHEMBL4164708)
Affinity DataKd:  8.82E+3nMAssay Description:Binding affinity to N-terminal His-tagged full length EED (unknown origin) by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
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