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TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158849(CHEMBL3785164)
Affinity DataEC50:  9.00E+3nMAssay Description:Inhibition of full-length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 level after 24 hrs by DAPI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158849(CHEMBL3785164)
Affinity DataEC50:  1.20E+4nMAssay Description:Inhibition of KDM4A in human MCF7 cells assessed as increase in H3K9me3 level after 24 hrs by DAPI staining based immunofuorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataEC50:  8.70E+4nMAssay Description:Inhibition of human Flag-tagged KDM4A expressed in human HeLa cells assessed as increase in H3K9me3 level after 24 hrs by DAPI staining based immunof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158888(CHEMBL3785984)
Affinity DataEC50:  3.80E+3nMAssay Description:Inhibition of human Flag-tagged KDM4A expressed in human HeLa cells assessed as increase in H3K9me3 level after 24 hrs by DAPI staining based immunof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454846(CHEMBL4211201)
Affinity DataKd:  21nMAssay Description:Binding affinity to biotinylated-KDM4A (unknown origin) at 300 nM by bio-layer interferometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454847(CHEMBL4203936)
Affinity DataEC50: >1.00E+5nMAssay Description:Stabilization of FLAG-tagged KDM4A (1 to 1064 residues) (unknown origin) expressed in human U2OS cells measured after 3 hrs by CETSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454851(CHEMBL4209558)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454852(CHEMBL4208111)
Affinity DataKd:  9nMAssay Description:Binding affinity to biotinylated-KDM4A (unknown origin) at 300 nM by bio-layer interferometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454854(CHEMBL4209038)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454848(CHEMBL4205285)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454855(CHEMBL4215000)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454850(CHEMBL4206582)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454852(CHEMBL4208111)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454857(CHEMBL4218482)
Affinity DataKd:  49nMAssay Description:Binding affinity to biotinylated-KDM4A (unknown origin) at 300 nM by bio-layer interferometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454849(CHEMBL4218675)
Affinity DataKd:  42nMAssay Description:Binding affinity to biotinylated-KDM4A (unknown origin) at 300 nM by bio-layer interferometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454853(CHEMBL4205183)
Affinity DataKd:  3.70nMAssay Description:Binding affinity to biotinylated-KDM4A (unknown origin) at 300 nM by bio-layer interferometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454851(CHEMBL4209558)
Affinity DataKd: >300nMAssay Description:Binding affinity to biotinylated-KDM4A (unknown origin) at 300 nM by bio-layer interferometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454854(CHEMBL4209038)
Affinity DataKd:  14nMAssay Description:Binding affinity to biotinylated-KDM4A (unknown origin) at 300 nM by bio-layer interferometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454858(CHEMBL4218774)
Affinity DataKd:  8.30nMAssay Description:Binding affinity to biotinylated-KDM4A (unknown origin) at 300 nM by bio-layer interferometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454855(CHEMBL4215000)
Affinity DataKd:  23nMAssay Description:Binding affinity to biotinylated-KDM4A (unknown origin) at 300 nM by bio-layer interferometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454850(CHEMBL4206582)
Affinity DataKd:  14nMAssay Description:Binding affinity to biotinylated-KDM4A (unknown origin) at 300 nM by bio-layer interferometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454859(CHEMBL4206181)
Affinity DataKd:  16nMAssay Description:Binding affinity to biotinylated-KDM4A (unknown origin) at 300 nM by bio-layer interferometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454849(CHEMBL4218675)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454844(CHEMBL4204694)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454858(CHEMBL4218774)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454856(CHEMBL4208277)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454845(CHEMBL4213743)
Affinity DataKd:  173nMAssay Description:Binding affinity to biotinylated-KDM4A (unknown origin) at 300 nM by bio-layer interferometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454848(CHEMBL4205285)
Affinity DataKd:  3.10nMAssay Description:Binding affinity to biotinylated-KDM4A (unknown origin) at 300 nM by bio-layer interferometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454847(CHEMBL4203936)
Affinity DataKd:  30nMAssay Description:Binding affinity to N-terminal His6-tagged KDM4A (1 to 359 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) Rosetta by bio-layer in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454844(CHEMBL4204694)
Affinity DataKd:  2.60nMAssay Description:Binding affinity to biotinylated-KDM4A (unknown origin) at 300 nM by bio-layer interferometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50457513(CHEMBL4212908)
Affinity DataKd:  2.27E+4nMAssay Description:Binding affinity to thrombin cleavable N-terminal 6His tagged and 13C-IVLM labeled human KDM4A tandem TUDOR domain (897 to 1011 residues) expressed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50457513(CHEMBL4212908)
Affinity DataKd:  1.55E+4nMAssay Description:Binding affinity to thrombin cleavable N-terminal 6His tagged and 13C-IVLM labeled human KDM4A tandem TUDOR domain (897 to 1011 residues) expressed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50457514(CHEMBL4204908)
Affinity DataEC50:  1.22E+6nMAssay Description:Inhibition of NanoLuc-KDM4A-TUDOR domain (unknown origin) binding to Histone H3.3-HaloTag expressed in 293T cells incubated for 18 hrs by Nano-BRET b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50457513(CHEMBL4212908)
Affinity DataKd:  5.51E+4nMAssay Description:Binding affinity to thrombin cleavable N-terminal 6His tagged and 13C-IVLM labeled human KDM4A tandem TUDOR domain (897 to 1011 residues) expressed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50457515(CHEMBL4208006)
Affinity DataKd:  3.00E+3nMAssay Description:Binding affinity to thrombin cleavable N-terminal 6His tagged and 13C-IVLM labeled human KDM4A tandem TUDOR domain (897 to 1011 residues) expressed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50457516(CHEMBL4214213)
Affinity DataKd:  4.70E+3nMAssay Description:Binding affinity to thrombin cleavable N-terminal 6His tagged and 13C-IVLM labeled human KDM4A tandem TUDOR domain (897 to 1011 residues) expressed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50457517(CHEMBL4208145)
Affinity DataKd:  8.00E+4nMAssay Description:Binding affinity to thrombin cleavable N-terminal 6His-tagged and 13C-IVLM labeled human KDM4A tandem TUDOR domain (897 to 1011 residues) expressed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50457513(CHEMBL4212908)
Affinity DataEC50:  1.05E+5nMAssay Description:Inhibition of NanoLuc-KDM4A-TUDOR domain (unknown origin) binding to Histone H3.3-HaloTag expressed in 293T cells incubated for 18 hrs by Nano-BRET b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50457513(CHEMBL4212908)
Affinity DataKd:  8.17E+4nMAssay Description:Binding affinity to thrombin cleavable N-terminal 6His tagged and 13C-IVLM labeled human KDM4A tandem TUDOR domain (897 to 1011 residues) expressed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50513360(CHEMBL4573390)
Affinity DataEC50:  5.90E+3nMAssay Description:Inhibition of FLAG tagged full length wild type human KDM4A transfected in HeLa cells assessed as decrease in demethylation of H3K9Me3 measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50513361(CHEMBL4567766)
Affinity DataEC50:  1.04E+4nMAssay Description:Inhibition of FLAG tagged full length wild type human KDM4A transfected in HeLa cells assessed as decrease in demethylation of H3K9Me3 measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50513345(CHEMBL4438830)
Affinity DataEC50:  3.03E+4nMAssay Description:Inhibition of FLAG tagged full length wild type human KDM4A transfected in HeLa cells assessed as decrease in demethylation of H3K9Me3 measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50513343(CHEMBL4449500)
Affinity DataEC50:  4.70E+3nMAssay Description:Inhibition of FLAG tagged full length wild type human KDM4A transfected in HeLa cells assessed as decrease in demethylation of H3K9Me3 measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50151923(CHEMBL3774537)
Affinity DataEC50:  8.50E+3nMAssay Description:Inhibition of FLAG tagged full length wild type human KDM4A transfected in HeLa cells assessed as decrease in demethylation of H3K9Me3 measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50088376(CHEBI:49005 | Deferasirox | Exjade | ICL670A | US1...)
Affinity DataEC50:  4.05E+4nMAssay Description:Inhibition of KDM4A in human KYSE-150 cells assessed as increase in H3K9me3 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50598654(CHEMBL5169996)
Affinity DataEC50:  3.30E+3nMAssay Description:Inhibition of KDM4A in human KYSE-150 cells assessed as increase in H3K9me3 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50598655(CHEMBL5178246)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of KDM4A in human KYSE-150 cells assessed as increase in H3K9me3 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50598662(CHEMBL5181544)
Affinity DataEC50:  1.05E+5nMAssay Description:Inhibition of binding of H3K4Me3 to KDM4A tudor domain (unknown origin) measured by NanoBRET-based cellular proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50454844(CHEMBL4204694)
Affinity DataIC50: 6nMAssay Description:Inhibition of KDM4A (unknown origin) expressed in Escherichia coli using biotinylated peptide as substrate pretreated for 15 mins followed by substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50598661(CHEMBL5203487)
Affinity DataIC50: 6nMAssay Description:Inhibition of KDM4A (unknown origin) measured by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
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