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TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM113734(N’-[3-(4-Methoxyphenyl)propyl]acetohydrazide ...)
Affinity DatapH: 7.5Assay Description:Reactions (100 µL) were initiated by the addition of 2 µL of GST-LSD1 (final concentration 96-154 nM). The reaction mixture contained 50 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2014
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50262071(CHEMBL4100487)
Affinity DataKd:  61nMAssay Description:Binding affinity to LSD1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2020
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50242887(CHEMBL4080173)
Affinity DataKd:  230nMAssay Description:Reversible inhibition of human recombinant N-terminal truncated LSD1 (151 to 852 residues) expressed in Escherichia coli by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50503509(CHEMBL4440004 | US10626103, Example 16)
Affinity DataEC50:  66nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of CD11b expression after 4 days by LIVE/DEAD violet staining based FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50241495(CHEMBL4079933)
Affinity DataKd:  190nMAssay Description:Binding affinity to LSD1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50503513(CHEMBL4453520 | US10626103, Example 48)
Affinity DataEC50:  50nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of CD11b expression after 4 days by LIVE/DEAD violet staining based FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50503514(CHEMBL4522607 | US10626103, Example 55)
Affinity DataEC50:  8nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of CD11b expression after 4 days by LIVE/DEAD violet staining based FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50545732(CHEMBL4638408)
Affinity DataEC50:  362nMAssay Description:Inhibition of LSD1 in human MV4-11 cells assessed as induction of LY96 mRNA expression incubated for 16 hrs by chemiluminescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50610594(CHEMBL5290398)
Affinity DataKd:  385nMAssay Description:Binding affinity to LSD1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50503503(CHEMBL4548929 | US10626103, Example 22)
Affinity DataEC50:  26nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of CD11b expression after 4 days by LIVE/DEAD violet staining based FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50262023(CHEMBL4071991)
Affinity DataKd:  22nMAssay Description:Binding affinity to LSD1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2020
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50582454(CHEMBL5075646)
Affinity DataKd:  3.83E+3nMAssay Description:Binding affinity to LSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50242892(CHEMBL4088045)
Affinity DataKd:  32nMAssay Description:Reversible inhibition of human recombinant N-terminal truncated LSD1 (151 to 852 residues) expressed in Escherichia coli by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50278411(CHEMBL4170367)
Affinity DataEC50: >20nMAssay Description:Inhibition of LSD1 in human MV-4-11 cells assessed as increase in CD86 mRNA expression after 3 days by SYBR Green dye-bsed RT-qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2020
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50507295(CHEMBL1232432)
Affinity DataKd:  243nMAssay Description:Binding affinity to LSD1 (unknown origin) assessed as dissociation constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50503631(CHEMBL4436792)
Affinity DataKd:  1nMAssay Description:Binding affinity to full length LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE) assessed as dissociation rate constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50503494(CHEMBL4437892)
Affinity DataEC50:  140nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of CD11b expression after 4 days by LIVE/DEAD violet staining based FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50503510(CHEMBL4465367 | US10626103, Example 63)
Affinity DataEC50:  59nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of CD11b expression after 4 days by LIVE/DEAD violet staining based FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50262070(CHEMBL4092760)
Affinity DataKd:  98nMAssay Description:Binding affinity to LSD1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2020
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50241498(CHEMBL4059468)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to LSD1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50545729(CHEMBL4646795)
Affinity DataEC50:  52nMAssay Description:Inhibition of LSD1 in human MV4-11 cells assessed as induction of LY96 mRNA expression incubated for 16 hrs by chemiluminescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50278459(CHEMBL4176756)
Affinity DataEC50: >20nMAssay Description:Inhibition of LSD1 in human MV-4-11 cells assessed as increase in CD86 mRNA expression after 3 days by SYBR Green dye-bsed RT-qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2020
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50242950(CHEMBL4074334)
Affinity DataKd:  13nMAssay Description:Reversible inhibition of human recombinant N-terminal truncated LSD1 (151 to 852 residues) expressed in Escherichia coli by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50241519(CHEMBL4073481)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to LSD1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50242896(CHEMBL4093330)
Affinity DataKd:  330nMAssay Description:Reversible inhibition of human recombinant N-terminal truncated LSD1 (151 to 852 residues) expressed in Escherichia coli by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50503515(CHEMBL4560537 | US10626103, Example 83)
Affinity DataEC50:  160nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of CD11b expression after 4 days by LIVE/DEAD violet staining based FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50545734(CHEMBL4647263)
Affinity DataEC50:  312nMAssay Description:Inhibition of LSD1 in human MV4-11 cells assessed as induction of LY96 mRNA expression incubated for 16 hrs by chemiluminescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50242954(CHEMBL4101067)
Affinity DataKd:  21nMAssay Description:Reversible inhibition of human recombinant N-terminal truncated LSD1 (151 to 852 residues) expressed in Escherichia coli by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM283216(US9573930, Example 86 | US10023543, Example 86 | 4...)
Affinity DataEC50:  3nMAssay Description:Inhibition of LSD1 in human NCI-H69 cells assessed as suppression of GRP mRNA expression incubated for 4 days by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50242894(CHEMBL4074323)
Affinity DataKd:  17nMAssay Description:Reversible inhibition of human recombinant N-terminal truncated LSD1 (151 to 852 residues) expressed in Escherichia coli by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50503496(CHEMBL4527219 | US10626103, Example 15)
Affinity DataEC50:  150nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of CD11b expression after 4 days by LIVE/DEAD violet staining based FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50524592(CHEMBL4550944)
Affinity DataKd:  2.02E+5nMAssay Description:Binding affinity to LSD1 (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50240772((1R,2S)-2-phenylcyclopropanamine | cid_2723716 | (...)
Affinity DataKd:  1.01E+5nMAssay Description:Binding affinity to recombinant LSD1(unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50242943(CHEMBL4065043)
Affinity DataKd:  1.70E+3nMAssay Description:Reversible inhibition of human recombinant N-terminal truncated LSD1 (151 to 852 residues) expressed in Escherichia coli by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50262048(CHEMBL3134377)
Affinity DataEC50:  62nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of CD11b expression after 4 days by LIVE/DEAD violet staining based FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50503499(CHEMBL4454128 | US10626103, Example 18)
Affinity DataEC50:  34nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of CD11b expression after 4 days by LIVE/DEAD violet staining based FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50241516(CHEMBL4083030)
Affinity DataKd:  2.40E+3nMAssay Description:Binding affinity to LSD1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataEC50:  54nMAssay Description:Inhibition of LSD1 in human MV4-11 cells assessed as induction of LY96 mRNA expression incubated for 16 hrs by chemiluminescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50241493(CHEMBL4103264)
Affinity DataKd:  140nMAssay Description:Binding affinity to LSD1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50242953(CHEMBL4066749)
Affinity DataKd:  42nMAssay Description:Reversible inhibition of human recombinant N-terminal truncated LSD1 (151 to 852 residues) expressed in Escherichia coli by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50545727(CHEMBL4637906)
Affinity DataEC50:  6nMAssay Description:Inhibition of LSD1 in human MV4-11 cells assessed as induction of LY96 mRNA expression incubated for 16 hrs by chemiluminescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50242957(CHEMBL4100451)
Affinity DataKd:  450nMAssay Description:Reversible inhibition of human recombinant N-terminal truncated LSD1 (151 to 852 residues) expressed in Escherichia coli by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50242946(CHEMBL4062278)
Affinity DataKd:  760nMAssay Description:Reversible inhibition of human recombinant N-terminal truncated LSD1 (151 to 852 residues) expressed in Escherichia coli by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50242947(CHEMBL4083993)
Affinity DataKd:  3.90E+3nMAssay Description:Reversible inhibition of human recombinant N-terminal truncated LSD1 (151 to 852 residues) expressed in Escherichia coli by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50241528(CHEMBL4071901)
Affinity DataKd:  460nMAssay Description:Binding affinity to LSD1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50242956(CHEMBL4085581)
Affinity DataKd:  120nMAssay Description:Reversible inhibition of human recombinant N-terminal truncated LSD1 (151 to 852 residues) expressed in Escherichia coli by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50545722(CHEMBL4649041)
Affinity DataEC50:  7nMAssay Description:Inhibition of LSD1 in human MV4-11 cells assessed as induction of LY96 mRNA expression incubated for 16 hrs by chemiluminescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50242905(CHEMBL4103503)
Affinity DataKd:  34nMAssay Description:Reversible inhibition of human recombinant N-terminal truncated LSD1 (151 to 852 residues) expressed in Escherichia coli by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50242889(CHEMBL4069461)
Affinity DataKd:  140nMAssay Description:Reversible inhibition of human recombinant N-terminal truncated LSD1 (151 to 852 residues) expressed in Escherichia coli by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

LigandPNGBDBM50241509(CHEMBL4086227)
Affinity DataKd:  6.50E+3nMAssay Description:Binding affinity to LSD1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
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