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TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536235(Lomibuvir | VX-222)
Affinity DataEC50:  320nMAssay Description:Inhibition of HCV genotype 1a NS5B L419M mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50482399(CHEMBL1210272)
Affinity DataKd:  3.99E+3nMAssay Description:Inhibition of HCV NS5B polymerase M414T mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50482398(CHEMBL1210273)
Affinity DataKd:  597nMAssay Description:Inhibition of HCV NS5B polymerase M414T mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM35554(thiophene scaffold, 21)
Affinity DataKd:  427nMAssay Description:Inhibition of HCV NS5B polymerase L419M mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM35554(thiophene scaffold, 21)
Affinity DataKd:  33nMAssay Description:Inhibition of HCV NS5B polymerase M414T mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50482399(CHEMBL1210272)
Affinity DataKd:  2.31E+4nMAssay Description:Inhibition of HCV NS5B polymerase L419M mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50482398(CHEMBL1210273)
Affinity DataKd:  4.48E+3nMAssay Description:Inhibition of HCV NS5B polymerase L419M mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536234(CHEMBL4580214)
Affinity DataEC50:  120nMAssay Description:Inhibition of HCV genotype 1a NS5B M423V mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536234(CHEMBL4580214)
Affinity DataEC50:  280nMAssay Description:Inhibition of HCV genotype 1a NS5B M423T mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536234(CHEMBL4580214)
Affinity DataEC50:  400nMAssay Description:Inhibition of HCV genotype 1a NS5B L419I mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536234(CHEMBL4580214)
Affinity DataEC50:  240nMAssay Description:Inhibition of HCV genotype 1a NS5B L419M mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536235(Lomibuvir | VX-222)
Affinity DataEC50:  310nMAssay Description:Inhibition of HCV genotype 1a NS5B M423T mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536235(Lomibuvir | VX-222)
Affinity DataEC50:  65nMAssay Description:Inhibition of HCV genotype 1a NS5B M423V mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536235(Lomibuvir | VX-222)
Affinity DataEC50:  30nMAssay Description:Inhibition of HCV genotype 1a NS5B M423I mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536234(CHEMBL4580214)
Affinity DataEC50:  89nMAssay Description:Inhibition of HCV genotype 1a NS5B M423I mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536235(Lomibuvir | VX-222)
Affinity DataEC50:  320nMAssay Description:Inhibition of HCV genotype 1a NS5B L419I mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50495951(CHEMBL3121193)
Affinity DataIC50: 130nMAssay Description:Inhibition of Hepatitis C virus genotype 1b NS5B Cdelta21 RNA dependent RNA polymerase 316N mutant using biotinylated polyC:oligoG/[alpha-P33]-GTP as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50454876(HCV 796 | HCV-796 | Nesbuvir)
Affinity DataIC50: 160nMAssay Description:Inhibition of Hepatitis C virus genotype 1b NS5B Cdelta21 RNA dependent RNA polymerase 316N mutant using biotinylated polyC:oligoG/[alpha-P33]-GTP as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50497155(CHEMBL3291362)
Affinity DataIC50: 380nMAssay Description:Inhibition of purified Hepatitis C virus NS5B polymerase S282T mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50497157(CHEMBL3286448)
Affinity DataIC50: 480nMAssay Description:Inhibition of purified Hepatitis C virus NS5B polymerase S282T mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50484982(CHEMBL2017865)
Affinity DataIC50: 600nMAssay Description:Inhibition of Hepatitis C virus NS5B RNA-dependent RNA polymerase P495L mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333128(((2S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-...)
Affinity DataIC50: 770nMAssay Description:Inhibition of HCV NS5B polymerase S282T mutant assessed as blocking of full length RNA product formation by single-nucleotide incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50497158(CHEMBL3291360)
Affinity DataIC50: 1.44E+3nMAssay Description:Inhibition of purified Hepatitis C virus NS5B polymerase S282T mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50484986(CHEMBL2017863)
Affinity DataIC50: 1.73E+3nMAssay Description:Inhibition of Hepatitis C virus NS5B RNA-dependent RNA polymerase P495L mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50484981(CHEMBL2017862)
Affinity DataIC50: 2.28E+3nMAssay Description:Inhibition of Hepatitis C virus NS5B RNA-dependent RNA polymerase P495L mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50484983(CHEMBL2017866)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of Hepatitis C virus NS5B RNA-dependent RNA polymerase P495L mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50491701(CHEMBL2387643)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of HCV NS5B polymerase P495L mutant assessed as inhibition of radioactive UMP incorporation into nascent RNA using poly aA/U12 template-pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50491701(CHEMBL2387643)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of HCV NS5B polymerase M423T mutant assessed as inhibition of radioactive UMP incorporation into nascent RNA using poly aA/U12 template-pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50484985(CHEMBL2017864)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of Hepatitis C virus NS5B RNA-dependent RNA polymerase P495L mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50484977(CHEMBL2017856)
Affinity DataIC50: 3.39E+3nMAssay Description:Inhibition of Hepatitis C virus NS5B RNA-dependent RNA polymerase P495L mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50491700(CHEMBL2387641)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of HCV NS5B polymerase P495L mutant assessed as inhibition of radioactive UMP incorporation into nascent RNA using poly aA/U12 template-pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50484984(CHEMBL2017858)
Affinity DataIC50: 3.72E+3nMAssay Description:Inhibition of Hepatitis C virus NS5B RNA-dependent RNA polymerase P495L mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50491700(CHEMBL2387641)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of HCV NS5B polymerase M423T mutant assessed as inhibition of radioactive UMP incorporation into nascent RNA using poly aA/U12 template-pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50484980(CHEMBL2017861)
Affinity DataIC50: 4.84E+3nMAssay Description:Inhibition of Hepatitis C virus NS5B RNA-dependent RNA polymerase P495L mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50484979(CHEMBL2017860)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of Hepatitis C virus NS5B RNA-dependent RNA polymerase P495L mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50496929(CHEMBL3233234)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of RNA-dependent RNA polymerase activity of HCV genotype 1b HC-J4 recombinant N-terminal histidine tagged C-terminal 21 aminoacids truncat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50495953(CHEMBL3121385)
Affinity DataIC50: 5.31E+3nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50484978(CHEMBL2017857)
Affinity DataIC50: 5.85E+3nMAssay Description:Inhibition of Hepatitis C virus NS5B RNA-dependent RNA polymerase P495L mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50484704(CHEMBL1950242)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of Hepatitis C virus NS5B Cdelta 21 RNA dependent RNA polymerase S282T mutant expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50484706(CHEMBL1950241)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of Hepatitis C virus NS5B Cdelta 21 RNA dependent RNA polymerase S282T mutant expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM86487(NSC_0 | CAS_0 | ATP,3'-deoxy)
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of HCV NS5B polymerase S282T mutant assessed as blocking of full length RNA product formation by single-nucleotide incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50496929(CHEMBL3233234)
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of RNA-dependent RNA polymerase activity of HCV genotype 1b HC-J4 recombinant N-terminal histidine tagged C-terminal 21 aminoacids truncat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50495954(CHEMBL3121384)
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50497159(CHEMBL3291361)
Affinity DataIC50: 1.28E+4nMAssay Description:Inhibition of purified Hepatitis C virus NS5B polymerase S282T mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50484705(CHEMBL1950240)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of Hepatitis C virus NS5B Cdelta 21 RNA dependent RNA polymerase S282T mutant expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50497154(CHEMBL3286449)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of purified Hepatitis C virus NS5B polymerase S282T mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50491701(CHEMBL2387643)
Affinity DataIC50: 4.78E+4nMAssay Description:Inhibition of HCV NS5B polymerase M414T mutant assessed as inhibition of radioactive UMP incorporation into nascent RNA using poly aA/U12 template-pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50478972(2''C-Me-CTP | CHEMBL223585)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of Hepatitis C virus NS5B Cdelta 21 RNA dependent RNA polymerase S282T mutant expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50491700(CHEMBL2387641)
Affinity DataIC50: 5.57E+4nMAssay Description:Inhibition of HCV NS5B polymerase M414T mutant assessed as inhibition of radioactive UMP incorporation into nascent RNA using poly aA/U12 template-pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50495956(PS-6130 | CHEMBL223482)
Affinity DataIC50: 5.67E+4nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
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