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TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50461664(CHEMBL4228446)
Affinity DataEC50:  5.76E+3nMAssay Description:Activation of MAGL in mouse B16-F10 cells using 7-HRA as substrate preincubated for 60 mins followed by substrate addition measured every 2.5 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50624860(CHEMBL5434963)
Affinity DataKd:  24nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM631219(US11802133, Example 75)
Affinity DataKd:  5.70nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50624852(CHEMBL5406688)
Affinity DataKd:  57nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50569655(CHEMBL4869836 | US11802133, Example 279)
Affinity DataKd:  6.10nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50624853(CHEMBL5420333)
Affinity DataKd:  15nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM631260(US11802133, Example 139)
Affinity DataKd:  30nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50624854(CHEMBL5400280)
Affinity DataKd:  29nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50624855(CHEMBL5402965)
Affinity DataKd:  41nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50624856(CHEMBL5438424)
Affinity DataKd:  30nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50624859(CHEMBL5434749)
Affinity DataKd:  27nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50643000(CHEMBL5569248)
Affinity DataIC50: 0.0260nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50642996(CHEMBL5575673)
Affinity DataIC50: 0.0490nMMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50247050(4-cyanophenyl ethyl dodecylphosphonate | CHEMBL462...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50160283(CHEMBL3787346)
Affinity DataIC50: 0.0700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50643000(CHEMBL5569248)
Affinity DataIC50: 0.0720nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50642986(CHEMBL6067709)
Affinity DataIC50: 0.0810nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: 0.105nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50247049(ethyl 3,5,6-trichloropyridin-2-yl dodecylphosphona...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50450776(CHEMBL4203881)
Affinity DataIC50: 0.180nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50450752(CHEMBL4216513)
Affinity DataIC50: 0.191nMAssay Description:Inhibition of mouse MAGLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50099618(CHEMBL1232635)
Affinity DataIC50: 0.219nMAssay Description:Inhibition of mouse MAGLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50099618(CHEMBL1232635)
Affinity DataIC50: 0.219nMAssay Description:Inhibition of mouse MAGLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50065646(CHEMBL3087181)
Affinity DataIC50: 0.275nMAssay Description:Inhibition of mouse MAGLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50065646(CHEMBL3087181)
Affinity DataIC50: 0.275nMAssay Description:Inhibition of mouse MAGLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50247051(isopropyl 4-nitrophenyl dodecylphosphonate | CHEMB...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50102829(CHEMBL3356956)
Affinity DataIC50: 0.309nMAssay Description:Inhibition of mouse MAGLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50247052(2-Nonylsulfanyl-4H-benzo[1,3,2]dioxaphosphinine 2-...)
Affinity DataIC50: 0.310nMAssay Description:Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: 0.357nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50132717(Isopropyl dodecylfluorophosphonate | isopropyl dod...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50132717(Isopropyl dodecylfluorophosphonate | isopropyl dod...)
Affinity DataIC50: 0.800nMAssay Description:Displacement of 2-arachidonylglycerol from MAGL in Swiss Webster mouse brain after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50642994(CHEMBL5570087)
Affinity DataIC50: 1.10nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50247048(methyl icosylphosphonofluoridate | CHEMBL462609)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50450707(CHEMBL4215558)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of mouse MAGLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50324698(Ethyl octylfluorophosphonate | CHEMBL1222256)
Affinity DataIC50: 5nMAssay Description:Displacement of 2-arachidonylglycerol from MAGL in Swiss Webster mouse brain after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM26736(N,N-dimethyl-5-[(4-phenylphenyl)methyl]-1H-1,2,3,4...)
Affinity DataIC50: 5.30nMpH: 7.4 T: 2°CAssay Description:Serine hydrolase targets were recombinantly expressed in COS-7 cells by transient transfection. IC50 values were obtained by competitive ABPP with F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2009
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US9133148, A | US11753371, Compound...)
Affinity DataIC50: 6nMAssay Description:Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brain membranes preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US9133148, A | US11753371, Compound...)
Affinity DataIC50: 6nMAssay Description:Inhibition of MAGL in mouse brain membrane using 2-AG as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50624852(CHEMBL5406688)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of mouse MAGLMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50569655(CHEMBL4869836 | US11802133, Example 279)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of mouse MAGLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM179950(US9133148, 3a)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of mouse MAGL preincubated for 30 mins followed by FP-Rh addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US9133148, A | US11753371, Compound...)
Affinity DataIC50: 8nMAssay Description:Inhibition of MAGL in C57B1/6J mouse brain membrane after 30 mins by using 2-AG as a substrate by LC-MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US9133148, A | US11753371, Compound...)
Affinity DataIC50: 8nMAssay Description:Inhibition of mouse recombinant MAGL expressed in african green monkey COS7 cells assessed as inhibition of 2-AG hydrolysis after 30 mins by LC-MS an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50505181(CHEMBL4559005)
Affinity DataIC50: 8nMAssay Description:Inhibition of FP-rhodamine probe binding to MGLL in mouse brain membrane proteome preincubated for 1 hr followed by FP-rhodamine addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50503336(CHEMBL4437377)
Affinity DataIC50: 8nMAssay Description:Inhibition of MGLL derived from mouse brain homogenates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US9133148, A | US11753371, Compound...)
Affinity DataIC50: 8nMAssay Description:Inhibition of mouse MAGLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50584756(CHEMBL5089326)
Affinity DataIC50: 8nMAssay Description:Inhibition of mouse MAGL using 2-AG as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US9133148, A | US11753371, Compound...)
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50584739(CHEMBL5082041)
Affinity DataIC50: 9nMAssay Description:Inhibition of mouse MAGL using 2-AG as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM631260(US11802133, Example 139)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of mouse MAGLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
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