Compile Data Set for Download or QSAR
Report error Found 105 of affinity data for UniProtKB/TrEMBL: O35435
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50598923(CHEMBL5193821)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse DHODHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50407985(CHEMBL2111978)
Affinity DataIC50: 22nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054601(5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole...)
Affinity DataIC50: 30nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054553((Z)-2-Cyano-N-(4-cyano-3-methyl-phenyl)-3-cyclopro...)
Affinity DataIC50: 36nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054584((Z)-N-(4-Chloro-phenyl)-2-cyano-3-cyclopropyl-3-hy...)
Affinity DataIC50: 36nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054548((Z)-N-(4-Bromo-phenyl)-2-cyano-3-cyclopropyl-3-hyd...)
Affinity DataIC50: 36nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054594((Z)-N-(4-Chloro-3-methyl-phenyl)-2-cyano-3-cyclopr...)
Affinity DataIC50: 40nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054587(Alpha-cyano-beta-hydroxy enamide, 6 | CHEMBL141195...)
Affinity DataIC50: 42nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM29024(CHEMBL141732 | cyanocyclopropylpropenamide, 4)
Affinity DataIC50: 47nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054557((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-nitro-phe...)
Affinity DataIC50: 50nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054560((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(3-methyl-4-...)
Affinity DataIC50: 55nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054565(CHEMBL141472 | CHEMBL344613 | (2Z,4E)-2-Cyano-3-hy...)
Affinity DataIC50: 63nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054578((Z)-N-(4-Bromo-3-methyl-phenyl)-2-cyano-3-cyclopro...)
Affinity DataIC50: 63nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM14712(A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...)
Affinity DataIC50: 69nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054564((Z)-2-Cyano-3-cyclopropyl-N-(3-ethyl-4-trifluorome...)
Affinity DataIC50: 71nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50018006(CHEMBL3289672 | US9238653, Table 5, Compound 49)
Affinity DataIC50: 88nMAssay Description:Inhibition of mouse DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054585((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-trifluoro...)
Affinity DataIC50: 89nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054573((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-trifluoro...)
Affinity DataIC50: 100nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50018011(CHEBI:68540 | HMR-1726 | Aubagio | TERIFLUNOMIDE)
Affinity DataIC50: 110nMAssay Description:Inhibition of C-terminal His6-tagged mouse DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50598913(CHEMBL5193591)
Affinity DataIC50: 140nMAssay Description:Inhibition of mouse DHODHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50018011(CHEBI:68540 | HMR-1726 | Aubagio | TERIFLUNOMIDE)
Affinity DataIC50: 150nMAssay Description:Inhibition of mouse DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM14712(A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...)
Affinity DataIC50: 156nMAssay Description:Inhibitory activity against mouse dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054549((Z)-N-(5-Bromo-pyridin-2-yl)-2-cyano-3-cyclopropyl...)
Affinity DataIC50: 158nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054597((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(5-trifluoro...)
Affinity DataIC50: 158nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054556((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-trifluoro...)
Affinity DataIC50: 173nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054590((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(3-methyl-4-...)
Affinity DataIC50: 178nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054600(2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)pen...)
Affinity DataIC50: 178nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054574((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(3-methyl-4-...)
Affinity DataIC50: 178nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50018008(CHEMBL3289671 | US9238653, Table 5, Compound 43)
Affinity DataIC50: 180nMAssay Description:Inhibition of mouse DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054543(2-cyano-3-hydroxy-4-methyl-N-(4-(trifluoromethyl)p...)
Affinity DataIC50: 195nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054555((Z)-N-(5-Chloro-pyridin-2-yl)-2-cyano-3-cyclopropy...)
Affinity DataIC50: 200nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054550((Z)-2-Cyano-3-cyclobutyl-3-hydroxy-N-(4-trifluorom...)
Affinity DataIC50: 209nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054541((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(3-methyl-4-...)
Affinity DataIC50: 282nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054591((Z)-N-(3-Chloro-4-methyl-phenyl)-2-cyano-3-cyclopr...)
Affinity DataIC50: 282nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054547((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-p-tolyl-acry...)
Affinity DataIC50: 288nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054581((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-trifluoro...)
Affinity DataIC50: 417nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM15344(2-({2,3,5,6-tetrafluoro-4-[3-(trifluoromethoxy)phe...)
Affinity DataIC50: 422nMAssay Description:Inhibitory activity against mouse dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054552((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-methylsul...)
Affinity DataIC50: 445nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054599((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(3-trifluoro...)
Affinity DataIC50: 525nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054554((Z)-N-[4-(4-Chloro-benzoyl)-phenyl]-2-cyano-3-cycl...)
Affinity DataIC50: 562nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054563((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-phenoxy-p...)
Affinity DataIC50: 630nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054589((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-phenethyl...)
Affinity DataIC50: 630nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054561((Z)-N-[4-(4-Chloro-phenoxy)-phenyl]-2-cyano-3-cycl...)
Affinity DataIC50: 832nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054545(4-((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-acryloylami...)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054603((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-[4-(4-triflu...)
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM29026(CHEMBL142996 | cyanocyclopropylpropenamide, 11)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054569((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-phenyl-acryl...)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50018007(CHEMBL3289670 | US9238653, Table 5, Compound 42)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of mouse DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50054562((Z)-N-(6-Chloro-pyridin-3-yl)-2-cyano-3-cyclopropy...)
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50173144(4-[3-Chloro-4-(2-chloro-6-fluoro-benzyloxy)-phenyl...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibitory activity against mouse dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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