Compile Data Set for Download or QSAR
Report error Found 13 of affinity data for UniProtKB/TrEMBL: O15455
TargetToll-like receptor 3(Human)
University of Colorado Boulder

Curated by ChEMBL
LigandPNGBDBM50239680(CHEMBL4064228)
Affinity DataEC50:  4.25E+4nMAssay Description:Agonist activity at human TLR3 expressed in HEK293 cells assessed as induction of NF-kB activation-mediated SEAP production after 24 hrs by HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
TargetToll-like receptor 3(Human)
University of Colorado Boulder

Curated by ChEMBL
LigandPNGBDBM50239682(CHEMBL4105063)
Affinity DataEC50:  2.23E+4nMAssay Description:Agonist activity at human TLR3 expressed in HEK293 cells assessed as induction of NF-kB activation-mediated SEAP production after 24 hrs by HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
TargetToll-like receptor 3(Human)
University of Colorado Boulder

Curated by ChEMBL
LigandPNGBDBM50239681(CHEMBL4074408)
Affinity DataEC50:  4.80E+3nMAssay Description:Agonist activity at human TLR3 expressed in HEK293 cells assessed as induction of NF-kB activation-mediated SEAP production after 24 hrs by HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
TargetToll-like receptor 3(Human)
University of Colorado Boulder

Curated by ChEMBL
LigandPNGBDBM50239682(CHEMBL4105063)
Affinity DataEC50:  2.23E+4nMAssay Description:Agonist activity at human TLR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 3(Human)
University of Colorado Boulder

Curated by ChEMBL
LigandPNGBDBM50239681(CHEMBL4074408)
Affinity DataEC50:  4.80E+3nMAssay Description:Agonist activity at human TLR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 3(Human)
University of Colorado Boulder

Curated by ChEMBL
LigandPNGBDBM50174412(CHEMBL19954 | cid_72512 | 9-Methoxy-5,11-dimethyl-...)
Affinity DataIC50: 110nMAssay Description:Inhibition of TLR3 in HEK-Blue hTLR3 assessed as inhibition of poly (I:C) induced SEAP signallingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetToll-like receptor 3(Human)
University of Colorado Boulder

Curated by ChEMBL
LigandPNGBDBM50543466(CHEMBL4647818)
Affinity DataIC50: 2.16E+3nMAssay Description:Antagonist activity at human TLR3 overexpressed in HEK-Blue cells assessed as inhibition of Poly IC-induced NFkappaB and AP-1 activation preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetToll-like receptor 3(Human)
University of Colorado Boulder

Curated by ChEMBL
LigandPNGBDBM50563780(CHEMBL4795714)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human TLR3 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as assessed as inhibition of poly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetToll-like receptor 3(Human)
University of Colorado Boulder

Curated by ChEMBL
LigandPNGBDBM50622091(CHEMBL4303728)
Affinity DataIC50: 3.44E+3nMAssay Description:Antagonist activity at TLR3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 3(Human)
University of Colorado Boulder

Curated by ChEMBL
LigandPNGBDBM50543465(CHEMBL4636498)
Affinity DataIC50: 5.44E+3nMAssay Description:Antagonist activity at human TLR3 overexpressed in HEK-Blue cells assessed as inhibition of Poly IC-induced NFkappaB and AP-1 activation preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetToll-like receptor 3(Human)
University of Colorado Boulder

Curated by ChEMBL
LigandPNGBDBM21958(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at Poly C stimulated human TRL3 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetToll-like receptor 3(Human)
University of Colorado Boulder

Curated by ChEMBL
LigandPNGBDBM50622090(CHEMBL5400196)
Affinity DataIC50: 1.54E+5nMAssay Description:Antagonist activity at TLR3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 3(Human)
University of Colorado Boulder

Curated by ChEMBL
LigandPNGBDBM50622091(CHEMBL4303728)
Affinity DataKi:  2.96E+3nMAssay Description:Binding affinity to TLR3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed