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Report error Found 186 of affinity data for UniProtKB/TrEMBL: B2RXH2
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153318(CHEMBL3775237)
Affinity DataIC50: 40nMAssay Description:Inhibition of KDM4E (unknown origin) using H3K9Me3 peptide as substrate assessed as demethylation of substrate by Rapidfire mass spectrometric analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153322(CHEMBL3775612)
Affinity DataIC50: 40nMAssay Description:Inhibition of KDM4E (unknown origin) using H3K9Me3 peptide as substrate assessed as demethylation of substrate by Rapidfire mass spectrometric analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153319(CHEMBL3775889)
Affinity DataIC50: 50nMAssay Description:Inhibition of KDM4E (unknown origin) using H3K9Me3 peptide as substrate assessed as demethylation of substrate by Rapidfire mass spectrometric analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396019(CHEMBL2169917 | 4'-(phenethylcarbamoyl)-[2,2&#...)
Affinity DataIC50: 110nMAssay Description:Inhibition of JMJD2E catalytic domain by mass spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396019(CHEMBL2169917 | 4'-(phenethylcarbamoyl)-[2,2&#...)
Affinity DataIC50: 110nMAssay Description:Inhibition of KDM4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149925(CHEMBL3770740)
Affinity DataIC50: 126nMAssay Description:Inhibition of KDM4E (unknown origin) by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM191600(US9714230, 89 | 2-(5-((4-chloro-2-methylbenzyl)oxy...)
Affinity DataIC50: 160nMAssay Description:Inhibition of KDM4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396020(CHEMBL1615036)
Affinity DataIC50: 180nMAssay Description:Inhibition of JMJD2E catalytic domain by mass spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50: 200nMAssay Description:Inhibition of human N-terminal His6-tagged KDM4E catalytic domain (1 to 337 residues) expressed in Escherichia coli using ARK(me3)STGGK as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50395083(CHEMBL2164246)
Affinity DataIC50: 200nMAssay Description:Inhibition of human KDM4E expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50395083(CHEMBL2164246)
Affinity DataIC50: 200nMAssay Description:Inhibition of human KDM4E heterogenously expressed in Escherichia coli using biotin-H3(1-15)K9Me3 as substrate and measured by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50: 200nMAssay Description:Inhibition of KDM4E (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50498665(CHEMBL1982368)
Affinity DataIC50: 290nMAssay Description:Inhibition of N-terminal His6-tagged human KDM4E (1 to 337 residues) measured by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant JMJD2E (unknown origin) incubated for 15 mins prior to substrate addition by AlphaScreen methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26113(pyridine-2,4-dicarboxylic acid | cid_10365 | pyrid...)
Affinity DataIC50: 300nMAssay Description:Inhibition of his6-tagged human recombinant KDM4E using K9me3 as substrate by SPE-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50: 316nMAssay Description:Inhibition of KDM4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50498665(CHEMBL1982368)
Affinity DataIC50: 316nMAssay Description:Inhibition of KDM4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50498665(CHEMBL1982368)
Affinity DataIC50: 340nMAssay Description:Inhibition of KDM4E (unknown origin ) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149924(CHEMBL3769511)
Affinity DataIC50: 398nMAssay Description:Inhibition of KDM4E (unknown origin) by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149920(CHEMBL3769724)
Affinity DataIC50: 398nMAssay Description:Inhibition of KDM4E (unknown origin) by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50498673(CHEMBL3621852)
Affinity DataIC50: 398nMAssay Description:Inhibition of KDM4E (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50129197(N-Hydroxy-succinamic acid | 4-(Hydroxyamino)-4-oxo...)
Affinity DataIC50: 400nMAssay Description:Inhibition of human KDM4E expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50495468(CHEMBL3108958)
Affinity DataIC50: 420nMAssay Description:Inhibition of recombinant JMJD2E (unknown origin) incubated for 15 mins prior to substrate addition by AlphaScreen methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 501nMAssay Description:Inhibition of KDM4E (unknown origin) by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149917(CHEMBL3771198)
Affinity DataIC50: 501nMAssay Description:Inhibition of KDM4E (unknown origin) by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50361146(CHEMBL1933775)
Affinity DataIC50: 900nMAssay Description:Inhibition of N-terminal His6-tagged KDM4E (1 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)-R3 preincubated for 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50361146(CHEMBL1933775)
Affinity DataIC50: 900nMAssay Description:Inhibition of N-terminal His6-tagged human KDM4E (1 to 337 residues) catalytic domain measured formaldehyde dehydrogenase (FDH)-coupled fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM79334(MLS002391556 | SMR001355524 | N-[3-(dimethylamino)...)
Affinity DataIC50: 920nMAssay Description:Inhibition of KDM4E (unknown origin) measured by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50627747(CHEMBL5429223)
Affinity DataIC50: 990nMAssay Description:Inhibition of human recombinant KDM4E using biotinylated-H3K9me3 peptide as substrate by SPE-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50122002(CHEMBL1383671)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of KDM4E (unknown origin) by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50627752(CHEMBL5430087)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of KDM4E (unknown origin) by SPE-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26113(pyridine-2,4-dicarboxylic acid | cid_10365 | pyrid...)
Affinity DataIC50: 1.40E+3nMpH: 7.5 T: 2°CAssay Description:A coupled-assay for JMJD2E activity employing formaldehyde dehydrogenase (FDH) from Pseudomonas putida was developed. Formaldehyde release by demethy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human N-terminal His6-tagged KDM4E catalytic domain (1 to 337 residues) expressed in Escherichia coli using ARK(me3)STGGK as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50627754(CHEMBL5422782)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of KDM4E (unknown origin) by SPE-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM191602(3-((1-methyl-1Hpyrrolo[2,3-b]pyridin-3-yl)amino)is...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of KDM4E (unknown origin ) incubated for 20 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50627743(CHEMBL5414235)
Affinity DataIC50: 2.36E+3nMAssay Description:Inhibition of human recombinant KDM4E using biotinylated-H3K9me3 peptide as substrate by SPE-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of JMJD2E catalytic domain by mass spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50627745(CHEMBL5415306)
Affinity DataIC50: 2.45E+3nMAssay Description:Inhibition of human recombinant KDM4E using biotinylated-H3K9me3 peptide as substrate by SPE-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50361472(CHEMBL1938896)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human JMJD2EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50009001(CHEMBL8260 | Baicalein | 5,6,7-Trihydroxyflavone |...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of JMJD2EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM81348(R115 (Reactive Blue 2) | β-Lapachone (A3) | b...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of JMJD2EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15236(CHEMBL164 | Cannabiscetin | 3,5,7-trihydroxy-2-(3,...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of JMJD2EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26113(pyridine-2,4-dicarboxylic acid | cid_10365 | pyrid...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of KDM4E (unknown origin ) incubated for 20 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50627732(CHEMBL5425339)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of N-terminal his6-tagged human recombinant KDM4E expressed in Escherichia coli using K9me3 as substrate by SPE-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50627737(CHEMBL5423565)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of N-terminal his6-tagged human recombinant KDM4E expressed in Escherichia coli using K9me3 as substrate by SPE-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50495470(CHEMBL3108954)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of recombinant JMJD2E (unknown origin) incubated for 15 mins prior to substrate addition by AlphaScreen methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50627735(CHEMBL5419332)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of N-terminal his6-tagged human recombinant KDM4E expressed in Escherichia coli using K9me3 as substrate by SPE-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50627748(CHEMBL5429166)
Affinity DataIC50: 3.69E+3nMAssay Description:Inhibition of human recombinant KDM4E using biotinylated-H3K9me3 peptide as substrate by SPE-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50495472(CHEMBL3108952)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of recombinant JMJD2E (unknown origin) incubated for 15 mins prior to substrate addition by AlphaScreen methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50579390(CHEMBL1571747)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human KDM4E (1 to 378 residues) catalytic domain measured formaldehyde dehydrogenase (FDH)-coupled fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
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