BDBM6622 1-{5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-9-yl}-3-{5-[(propan-2-ylamino)methyl]-1H-pyrazol-3-yl}urea::5-alkylaminomethyl pyrazole-3-yl urea deriv. 9c::N-{5-[(Isopropylamino)methyl]-1H-pyrazol-3-yl}-N -(5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-a]isoindol-9-yl)-urea

SMILES CC(C)NCc1cc(NC(=O)Nc2cccc3C(=O)N4CCCC4c23)[nH]n1

InChI Key InChIKey=FFKLNVQCVAPTNG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6622   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Banyu Tsukuba Research Institute

LigandPNGBDBM6622(1-{5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-9-yl}-...)
Affinity DataIC50: 130nMAssay Description:Src, Lck, Flt-1, ZAP, EGFR, FGFR1, and PFGFR-beta were assayed in the Merck research laboratory (Homogeneous proximity tyrosine kinase assays: scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2005
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Banyu Tsukuba Research Institute

LigandPNGBDBM6622(1-{5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-9-yl}-...)
Affinity DataIC50: 1.70E+4nMAssay Description:Src, Lck, Flt-1, ZAP, EGFR, FGFR1, and PFGFR-beta were assayed in the Merck research laboratory (Homogeneous proximity tyrosine kinase assays: scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2005
Entry Details Article
PubMed