BDBM50328850 (3R,4S)-N-(2-chloro-5-((methylamino)methyl)benzyl)-N-cyclopropyl-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)piperidine-3-carboxamide::CHEMBL1269674

SMILES CNCc1ccc(Cl)c(CN(C2CC2)C(=O)[C@H]2CNCC[C@@H]2c2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)c1

InChI Key InChIKey=VKUUNUNXIVLQGO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50328850   

TargetRenin(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328850((3R,4S)-N-(2-chloro-5-((methylamino)methyl)benzyl)...)
Affinity DataIC50: 1.39nMAssay Description:Inhibition of renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetRenin(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328850((3R,4S)-N-(2-chloro-5-((methylamino)methyl)benzyl)...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328850((3R,4S)-N-(2-chloro-5-((methylamino)methyl)benzyl)...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP3A4 using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328850((3R,4S)-N-(2-chloro-5-((methylamino)methyl)benzyl)...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of CYP3A4 using testosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed