BDBM42061 (R,E)-5-(5-(2-(2-(2-(methoxymethyl)-4-(pyridin-2-yl)piperazin-1-yl)pyrimidin-5-yl)vinyl)pyridin-2-yl)oxazole::WO2024186584, Example 26

SMILES COC[C@@H]1N(CCN(C1)C1=NC=CC=C1)C1=NC=C(C=N1)/C=C/C=1C=CC(=NC1)C1=CN=CO1

InChI Key InChIKey=ZNRAZOAQHCUASA-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 42061   

TargetAlpha-synuclein(Human)
8932 Hightail Drive

WIPO
LigandChemical structure of BindingDB Monomer ID 42061BDBM42061((R,E)-5-(5-(2-(2-(2-(methoxymethyl)-4-(pyridin-2-y...)
Affinity DataKi:  3.10nMAssay Description:The mutation underlying Huntington's disease is an expansion of a polyglutamine tract in the N-terminus of the protein huntingtin (htt). Under no...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2026
Entry Details
WIPO WO2024186584

TargetAmyloid-beta precursor protein(Human)
8932 Hightail Drive

WIPO
LigandChemical structure of BindingDB Monomer ID 42061BDBM42061((R,E)-5-(5-(2-(2-(2-(methoxymethyl)-4-(pyridin-2-y...)
Affinity DataKi:  1.20E+4nMAssay Description:The mutation underlying Huntington's disease is an expansion of a polyglutamine tract in the N-terminus of the protein huntingtin (htt). Under no...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2026
Entry Details
WIPO WO2024186584