Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 12584
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM144315(US8969336, 577 | US8969336, 547 | Gilteritinib | U...)
Affinity DataKi:  2nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM144315(US8969336, 577 | US8969336, 547 | Gilteritinib | U...)
Affinity DataKi:  6.30nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetReceptor-type tyrosine-protein kinase FLT3 [D835Y](Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712325(7-[3-(3,4-dimethoxyphenyl)-8-methoxy- 1H-pyrazolo[...)
Affinity DataKi: <10nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835Y](Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712322(7-[3-(3,4-dimethoxyphenyl)-1H- pyrazolo[4,3-c]quin...)
Affinity DataKi: <10nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712322(7-[3-(3,4-dimethoxyphenyl)-1H- pyrazolo[4,3-c]quin...)
Affinity DataKi: <10nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712320(5-[3-(3,4-dimethoxyphenyl)-8-methoxy-1H- pyrazolo[...)
Affinity DataKi: <10nMAssay Description:Table A: Primary Assay used to determine potency of HPK1 enzymatic activity inhibition. Compound activity was determined using recombinant HPK1 prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712319(6-[3-(3,4-dimethoxyphenyl)-8-methoxy-1H- pyrazolo[...)
Affinity DataKi: <10nMAssay Description:Table A: Primary Assay used to determine potency of HPK1 enzymatic activity inhibition. Compound activity was determined using recombinant HPK1 prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712325(7-[3-(3,4-dimethoxyphenyl)-8-methoxy- 1H-pyrazolo[...)
Affinity DataKi: <10nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712325(7-[3-(3,4-dimethoxyphenyl)-8-methoxy- 1H-pyrazolo[...)
Affinity DataKi: <10nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712319(6-[3-(3,4-dimethoxyphenyl)-8-methoxy-1H- pyrazolo[...)
Affinity DataKi: <10nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835Y](Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712319(6-[3-(3,4-dimethoxyphenyl)-8-methoxy-1H- pyrazolo[...)
Affinity DataKi: <10nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835Y](Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712324(5-[3-(3,4-dimethoxyphenyl)-1H- pyrazolo[4,3-c]quin...)
Affinity DataKi: <10nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712320(5-[3-(3,4-dimethoxyphenyl)-8-methoxy-1H- pyrazolo[...)
Affinity DataKi: <10nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835Y](Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712320(5-[3-(3,4-dimethoxyphenyl)-8-methoxy-1H- pyrazolo[...)
Affinity DataKi: <10nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712310(1-{3-[1-(2,3-dimethylphenyl)-8-methoxy- 1H-pyrazol...)
Affinity DataKi: <10nMAssay Description:Table A: Primary Assay used to determine potency of HPK1 enzymatic activity inhibition. Compound activity was determined using recombinant HPK1 prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835Y](Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM144315(US8969336, 577 | US8969336, 547 | Gilteritinib | U...)
Affinity DataKi:  13nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712324(5-[3-(3,4-dimethoxyphenyl)-1H- pyrazolo[4,3-c]quin...)
Affinity DataKi:  15nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712320(5-[3-(3,4-dimethoxyphenyl)-8-methoxy-1H- pyrazolo[...)
Affinity DataKi:  15nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712319(6-[3-(3,4-dimethoxyphenyl)-8-methoxy-1H- pyrazolo[...)
Affinity DataKi:  15nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712308(1-{3-[1-(3,4-dimethylphenyl)-8-methoxy- 1H-pyrazol...)
Affinity DataKi:  15nMAssay Description:Table A: Primary Assay used to determine potency of HPK1 enzymatic activity inhibition. Compound activity was determined using recombinant HPK1 prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835Y](Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712323(6-[3-(3,4-dimethoxyphenyl)-1H- pyrazolo[4,3-c]quin...)
Affinity DataKi:  15nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712323(6-[3-(3,4-dimethoxyphenyl)-1H- pyrazolo[4,3-c]quin...)
Affinity DataKi:  15nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712322(7-[3-(3,4-dimethoxyphenyl)-1H- pyrazolo[4,3-c]quin...)
Affinity DataKi:  15nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712316((2-{4-[1-(3,4-dimethylphenyl)-8-methoxy- 1H-pyrazo...)
Affinity DataKi:  15nMAssay Description:Table A: Primary Assay used to determine potency of HPK1 enzymatic activity inhibition. Compound activity was determined using recombinant HPK1 prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712312(1-{4-[1-(3,4-dimethylphenyl)-8-methoxy- 1H-pyrazol...)
Affinity DataKi:  15nMAssay Description:Table A: Primary Assay used to determine potency of HPK1 enzymatic activity inhibition. Compound activity was determined using recombinant HPK1 prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712311(1-{4-[1-(3,4-dimethylphenyl)-8-methoxy- 1H-pyrazol...)
Affinity DataKi:  15nMAssay Description:Table A: Primary Assay used to determine potency of HPK1 enzymatic activity inhibition. Compound activity was determined using recombinant HPK1 prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712309(1-{3-[1-(3,4-dimethylphenyl)-8-methoxy- 1H-pyrazol...)
Affinity DataKi:  15nMAssay Description:Table A: Primary Assay used to determine potency of HPK1 enzymatic activity inhibition. Compound activity was determined using recombinant HPK1 prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712324(5-[3-(3,4-dimethoxyphenyl)-1H- pyrazolo[4,3-c]quin...)
Affinity DataKi:  35nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712318(4-(3-{4-[1-(3,4-dimethylphenyl)-8- methoxy-1H-pyra...)
Affinity DataKi:  35nMAssay Description:Table A: Primary Assay used to determine potency of HPK1 enzymatic activity inhibition. Compound activity was determined using recombinant HPK1 prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712317(4-(2-{4-[1-(3,4-dimethylphenyl)-8- methoxy-1H-pyra...)
Affinity DataKi:  35nMAssay Description:Table A: Primary Assay used to determine potency of HPK1 enzymatic activity inhibition. Compound activity was determined using recombinant HPK1 prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712313(N-[3-(dimethylamino)propyl]-4-[1- (3,4-dimethylphe...)
Affinity DataKi:  35nMAssay Description:Table A: Primary Assay used to determine potency of HPK1 enzymatic activity inhibition. Compound activity was determined using recombinant HPK1 prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712323(6-[3-(3,4-dimethoxyphenyl)-1H- pyrazolo[4,3-c]quin...)
Affinity DataKi: >50nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712315(1-{4-[1-(3,4-dimethylphenyl)-1H- pyrazolo[4,3-c]qu...)
Affinity DataKi: >50nMAssay Description:Table A: Primary Assay used to determine potency of HPK1 enzymatic activity inhibition. Compound activity was determined using recombinant HPK1 prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712314(1-{4-[1-(3,4-dimethylphenyl)-1H- pyrazolo[4,3-c]qu...)
Affinity DataKi: >50nMAssay Description:Table A: Primary Assay used to determine potency of HPK1 enzymatic activity inhibition. Compound activity was determined using recombinant HPK1 prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent