Compile Data Set for Download or QSAR
Report error Found 64 Enz. Inhib. hit(s) with all data for entry = 2759
TargetDNA topoisomerase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259242(CHEMBL4072011 | US10266550, Compound 11e)
Affinity DataIC50: 240nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259247(CHEMBL4065223 | US10266550, Compound 11g)
Affinity DataIC50: 240nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259215(CHEMBL4064887 | US10266550, Compound 11b)
Affinity DataIC50: 240nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259221(CHEMBL4097472 | US10266550, Compound 11d)
Affinity DataIC50: 480nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259247(CHEMBL4065223 | US10266550, Compound 11g)
Affinity DataIC50: 480nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259214(CHEMBL4061346 | US10266550, Compound 11a)
Affinity DataIC50: 480nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259244(CHEMBL4076393 | US10266550, Compound 16)
Affinity DataIC50: 480nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259248(CHEMBL4104625 | US10266550, Compound 17bbSelectivi...)
Affinity DataIC50: 725nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259245(CHEMBL4064127 | US10266550, Compound 17a)
Affinity DataIC50: 725nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259242(CHEMBL4072011 | US10266550, Compound 11e)
Affinity DataIC50: 970nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259221(CHEMBL4097472 | US10266550, Compound 11d)
Affinity DataIC50: 970nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259212(CHEMBL2002459 | US10266550, Compound 1)
Affinity DataIC50: 1.95E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259246(CHEMBL4066307 | US10266550, Compound 10a)
Affinity DataIC50: 1.95E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259246(CHEMBL4066307 | US10266550, Compound 10a)
Affinity DataIC50: 1.95E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 2-alpha(Human)
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259215(CHEMBL4064887 | US10266550, Compound 11b)
Affinity DataIC50: 2.93E+3nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 2-alpha(Human)
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259247(CHEMBL4065223 | US10266550, Compound 11g)
Affinity DataIC50: 2.93E+3nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 2-alpha(Human)
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259244(CHEMBL4076393 | US10266550, Compound 16)
Affinity DataIC50: 2.93E+3nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM379475(US10266550, Compound 11j)
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Human)
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259248(CHEMBL4104625 | US10266550, Compound 17bbSelectivi...)
Affinity DataIC50: 3.90E+3nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM379468(US10266550, Compound 11c)
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259242(CHEMBL4072011 | US10266550, Compound 11e)
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259248(CHEMBL4104625 | US10266550, Compound 17bbSelectivi...)
Affinity DataIC50: 3.90E+3nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM379474(US10266550, Compound 11i)
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Human)
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259245(CHEMBL4064127 | US10266550, Compound 17a)
Affinity DataIC50: 3.90E+3nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM379465(US10266550, Compound 10b)
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 2-alpha(Human)
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259248(CHEMBL4104625 | US10266550, Compound 17bbSelectivi...)
Affinity DataIC50: 3.90E+3nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM379478(US10266550, Compound 15a)
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259245(CHEMBL4064127 | US10266550, Compound 17a)
Affinity DataIC50: 3.90E+3nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259244(CHEMBL4076393 | US10266550, Compound 16)
Affinity DataIC50: 3.90E+3nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Human)
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259247(CHEMBL4065223 | US10266550, Compound 11g)
Affinity DataIC50: 3.90E+3nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 2-alpha(Human)
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259214(CHEMBL4061346 | US10266550, Compound 11a)
Affinity DataIC50: 5.85E+3nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM379471(US10266550, Compound 11f)
Affinity DataIC50: 5.85E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 2-alpha(Human)
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259242(CHEMBL4072011 | US10266550, Compound 11e)
Affinity DataIC50: 5.85E+3nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259221(CHEMBL4097472 | US10266550, Compound 11d)
Affinity DataIC50: 7.80E+3nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Human)
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259215(CHEMBL4064887 | US10266550, Compound 11b)
Affinity DataIC50: 7.80E+3nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM379477(US10266550, Compound 12)
Affinity DataIC50: 7.80E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Human)
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259244(CHEMBL4076393 | US10266550, Compound 16)
Affinity DataIC50: 7.80E+3nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259215(CHEMBL4064887 | US10266550, Compound 11b)
Affinity DataIC50: 1.17E+4nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Human)
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259242(CHEMBL4072011 | US10266550, Compound 11e)
Affinity DataIC50: 1.17E+4nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM379476(US10266550, Compound 11k)
Affinity DataIC50: 1.56E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Human)
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259221(CHEMBL4097472 | US10266550, Compound 11d)
Affinity DataIC50: 1.56E+4nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259247(CHEMBL4065223 | US10266550, Compound 11g)
Affinity DataIC50: 1.56E+4nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 2-alpha(Human)
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259221(CHEMBL4097472 | US10266550, Compound 11d)
Affinity DataIC50: 1.56E+4nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Human)
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259214(CHEMBL4061346 | US10266550, Compound 11a)
Affinity DataIC50: 1.56E+4nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM379123(US10266550, Compound 6a | Ethyl 5,6-difluoro-9-nit...)
Affinity DataIC50: 1.56E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM379458(5, 6-Difluoro-9-nitro-3-oxo-3H-pyrido[3, 2,1-kl]ph...)
Affinity DataIC50: 1.56E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM379461(US10266550, Compound 7d)
Affinity DataIC50: 1.56E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259214(CHEMBL4061346 | US10266550, Compound 11a)
Affinity DataIC50: 2.34E+4nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259242(CHEMBL4072011 | US10266550, Compound 11e)
Affinity DataIC50: 2.34E+4nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259213(CHEMBL4079855 | US10266550, Compound 7e)
Affinity DataIC50: 3.13E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

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