Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) with all data for entry = 1876
TargetLeukotriene A-4 hydrolase(Human)
Celtaxsys

US Patent
LigandPNGBDBM345819(US10202362, Compound T2.2)
Affinity DataIC50: 1.80nMAssay Description:LTB4 formed was quantified with the HTRF assay in which free LTB4 competes with LTB4-XL665 conjugate (acceptor) for anti-LTB4 monoclonal antibody lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Celtaxsys

US Patent
LigandPNGBDBM345818(US10202362, Compound T2.1)
Affinity DataIC50: 2.10nMAssay Description:LTB4 formed was quantified with the HTRF assay in which free LTB4 competes with LTB4-XL665 conjugate (acceptor) for anti-LTB4 monoclonal antibody lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Celtaxsys

US Patent
LigandPNGBDBM345818(US10202362, Compound T2.1)
Affinity DataIC50: 7.10nMAssay Description:In brief, the enzyme (29 nM) was incubated with L-alanine-p-nitroanilide (1 mM) in 50 mM HEPES (pH 7.5), 100 mM KCL, 1% DMSO in the absence or presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Celtaxsys

US Patent
LigandPNGBDBM345819(US10202362, Compound T2.2)
Affinity DataIC50: 22nMAssay Description:In brief, the enzyme (29 nM) was incubated with L-alanine-p-nitroanilide (1 mM) in 50 mM HEPES (pH 7.5), 100 mM KCL, 1% DMSO in the absence or presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent