Compile Data Set for Download or QSAR
Report error Found 46 Enz. Inhib. hit(s) with all data for entry = 1132
TargetBromodomain-containing protein 9 [134-239](Human)
Genentech

US Patent
LigandPNGBDBM310899(US10150767, Example 39 | 4-[4-(1-hydroxy-1-methyl-...)
Affinity DataIC50: 21nMAssay Description:His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetBromodomain-containing protein 9 [134-239](Human)
Genentech

US Patent
LigandPNGBDBM310892(US10150767, Example 3 | N-(2-methoxyethyl)-4-(6-me...)
Affinity DataIC50: 24nMAssay Description:His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetBromodomain-containing protein 9 [134-239](Human)
Genentech

US Patent
LigandPNGBDBM310896(US10150767, Example 12 | 7-(6-methyl-7-oxo-1H-pyrr...)
Affinity DataIC50: 25nMAssay Description:His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetBromodomain-containing protein 9 [134-239](Human)
Genentech

US Patent
LigandPNGBDBM310895(US10150767, Example 11 | 3-methyl-7-(6-methyl-7-ox...)
Affinity DataIC50: 31nMAssay Description:His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetChromatin remodeling regulator CECR2 [424-538](Human)
Genentech

US Patent
LigandPNGBDBM310905(US10150767, Example 16 | 2-methyl-7-(6-methyl-7-ox...)
Affinity DataIC50: 36nMAssay Description:His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310889(US10150767, Example 34 | 4-(6-methyl-7-oxo-1H-pyrr...)
Affinity DataIC50: 51nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetBromodomain-containing protein 9 [134-239](Human)
Genentech

US Patent
LigandPNGBDBM310902(US10150767, Example 42 | 6-methyl-4-[4-(1-methyl-4...)
Affinity DataIC50: 53nMAssay Description:His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetBromodomain-containing protein 9 [134-239](Human)
Genentech

US Patent
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 53nMAssay Description:His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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PDB3D3D Structure (crystal)
TargetChromatin remodeling regulator CECR2 [424-538](Human)
Genentech

US Patent
LigandPNGBDBM310911(US10150767, Example 44 | 6-methyl-4-(2-methyl-3,4-...)
Affinity DataIC50: 54nMAssay Description:His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310880(US10150767, Example 17 | 7-(6-methyl-7-oxo-1H-pyrr...)
Affinity DataIC50: 58nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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LigandPNGBDBM310915(US10150767, Example 37 | N-benzyl-4-(6-methyl-7-ox...)
Affinity DataIC50: 63nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetBromodomain-containing protein 9 [134-239](Human)
Genentech

US Patent
LigandPNGBDBM310903(US10150767, Example 45 | 6-methyl-4-[4-[(1-methyl-...)
Affinity DataIC50: 64nMAssay Description:His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetChromatin remodeling regulator CECR2 [424-538](Human)
Genentech

US Patent
LigandPNGBDBM310910(US10150767, Example 35 | 4-(6-methyl-7-oxo-1H-pyrr...)
Affinity DataIC50: 75nMAssay Description:His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310879(US10150767, Example 15 | 2-(6-methyl-7-oxo-1H-pyrr...)
Affinity DataIC50: 81nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310884(US10150767, Example 27 | 4-[4-(3-fluoroazetidine-1...)
Affinity DataIC50: 84nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetBromodomain-containing protein 9 [134-239](Human)
Genentech

US Patent
LigandPNGBDBM310894(US10150767, Example 6 | tert-butyl N-[4-(6-methyl-...)
Affinity DataIC50: 85nMAssay Description:His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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LigandPNGBDBM310913(US10150767, Example 24 | N-methyl-3-(6-methyl-7-ox...)
Affinity DataIC50: 96nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetBromodomain-containing protein 9 [134-239](Human)
Genentech

US Patent
LigandPNGBDBM310901(US10150767, Example 41 | 6-cyclopropyl-4-(4-(2-hyd...)
Affinity DataIC50: 110nMAssay Description:His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310874(US10150767, Example 4 | tert-butyl 6-(6-methyl-7-o...)
Affinity DataIC50: 110nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310876(US10150767, Example 10 | 3-methyl-6-(6-methyl-7-ox...)
Affinity DataIC50: 110nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310878(US10150767, Example 14 | 3-isopropyl-6-(6-methyl-7...)
Affinity DataIC50: 110nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 9 [134-239](Human)
Genentech

US Patent
LigandPNGBDBM310893(US10150767, Example 5 | tert-butyl 7-(6-methyl-7-o...)
Affinity DataIC50: 130nMAssay Description:His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetChromatin remodeling regulator CECR2 [424-538](Human)
Genentech

US Patent
LigandPNGBDBM310912(US10150767, Example 47 | 3-(2,6-dimethyl-7-oxo-1H-...)
Affinity DataIC50: 130nMAssay Description:His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetChromatin remodeling regulator CECR2 [424-538](Human)
Genentech

US Patent
LigandPNGBDBM310909(US10150767, Example 28 | 4-[4-(3,3-difluoroazetidi...)
Affinity DataIC50: 130nMAssay Description:His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310882(US10150767, Example 23 | 3-(6-methyl-7-oxo-1H-pyrr...)
Affinity DataIC50: 150nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310877(US10150767, Example 13 | 4-methyl-7-(6-methyl-7-ox...)
Affinity DataIC50: 170nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetChromatin remodeling regulator CECR2 [424-538](Human)
Genentech

US Patent
LigandPNGBDBM310904(US10150767, Example 7 | 3-methoxy-N-[4-(6-methyl-7...)
Affinity DataIC50: 170nMAssay Description:His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310886(US10150767, Example 31 | 6-methyl-4-[4-(4-methylpi...)
Affinity DataIC50: 170nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310881(US10150767, Example 21 | 3-(6-methyl-7-oxo-1H-pyrr...)
Affinity DataIC50: 180nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310891(US10150767, Example 38 | N-(cyanomethyl)-N-methyl-...)
Affinity DataIC50: 200nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310873(US10150767, Example 2 | 6-methyl-4-(2-oxoindolin-5...)
Affinity DataIC50: 210nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 9 [134-239](Human)
Genentech

US Patent
LigandPNGBDBM310897(US10150767, Example 19 | N,N-dimethyl-3-(7-oxo-6-p...)
Affinity DataIC50: 238nMAssay Description:His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetChromatin remodeling regulator CECR2 [424-538](Human)
Genentech

US Patent
LigandPNGBDBM310908(US10150767, Example 26 | 6-methyl-4-(4-(4-methyl-3...)
Affinity DataIC50: 240nMAssay Description:His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310886(US10150767, Example 31 | 6-methyl-4-[4-(4-methylpi...)
Affinity DataIC50: 260nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310885(US10150767, Example 29 | 6-methyl-4-[4-(pyrrolidin...)
Affinity DataIC50: 280nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310875(US10150767, Example 9 | 8-(6-methyl-7-oxo-6,7-dihy...)
Affinity DataIC50: 310nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310887(US10150767, Example 32 | 4-[4-(4-acetylpiperazine-...)
Affinity DataIC50: 320nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310890(US10150767, Example 36 | N-methyl-4-(6-methyl-7-ox...)
Affinity DataIC50: 340nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

LigandPNGBDBM310914(US10150767, Example 30 | 6-methyl-4-[4-(morpholine...)
Affinity DataIC50: 350nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

LigandPNGBDBM310917(US10150767, Example 46 | 6-methyl-4-[3-[(1-methyl-...)
Affinity DataIC50: 440nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310872(US10150767, Example 1 | 6-methyl-4-phenyl-1H-pyrro...)
Affinity DataIC50: 540nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

LigandPNGBDBM310916(US10150767, Example 43 | 6-methyl-4-[3-(1-methyl-4...)
Affinity DataIC50: 680nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310883(US10150767, Example 25 | 4-[4-(hydroxymethyl)pheny...)
Affinity DataIC50: 710nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetChromatin remodeling regulator CECR2 [424-538](Human)
Genentech

US Patent
LigandPNGBDBM310906(US10150767, Example 18 | N,N-dimethyl-4-(6-methyl-...)
Affinity DataIC50: 730nMAssay Description:His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetChromatin remodeling regulator CECR2 [424-538](Human)
Genentech

US Patent
LigandPNGBDBM310907(US10150767, Example 20 | 3-(6-ethyl-7-oxo-1H-pyrro...)
Affinity DataIC50: 1.30E+3nMAssay Description:His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 9 [134-239](Human)
Genentech

US Patent
LigandPNGBDBM310900(US10150767, Example 40 | 4-[4-(1-hydroxy-1-methyl-...)
Affinity DataIC50: 4.10E+3nMAssay Description:His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent