Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50016433
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50537681(CHEMBL4640167)
Affinity DataEC50:  3.56E+3nMAssay Description:Inhibition of NAE-mediated neddylation in human MGC-803 cells assessed as effect on NEDD8-UBC12 coupling product formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50594972(CHEMBL5177755)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM320991(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50: 0.955nMAssay Description:Inhibition of recombinant human APPBP1/UBA3 expressed in Escherichia coli assessed as Ub/Ubl thioester transferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50: 4nMAssay Description:Inhibition of NAE1/UBA3 in human HCT-116 cells assessed as reduction in Ubc12-NEDD8 level incubated for 24 hrs by immunoblot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetUbiquitin-like modifier-activating enzyme 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50594972(CHEMBL5177755)
Affinity DataIC50: 66nMAssay Description:Inhibition of UAE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetUbiquitin-like modifier-activating enzyme 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM320991(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50: 449nMAssay Description:Inhibition of recombinant C-terminal His-tagged human full length UAE1 expressed in Escherichia coli BL21 (lambdaDE3) assessed as reduction in transf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM320991(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50: 730nMAssay Description:Inhibition of human erythrocyte carbonic anhydrase 2 using 4-Nitrophenyl acetate as substrate preincubated for 15 mins followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSUMO-activating enzyme subunit 1/2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM320991(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of recombinant human SAE1/UBA2 expressed in Escherichia coli assessed as reduction in transfer of UMO1 to UBE2I enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetUbiquitin-like modifier-activating enzyme 1(Mouse)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of mouse UAE1 in human HCT-116 cells assessed as reduction in Ubc10-Ub thioester level incubated for 24 hrs by immunoblot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetUbiquitin-like modifier-activating enzyme 6(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of His-tagged UBA6 (unknown origin) expressed in sf9 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSUMO-activating enzyme subunit 1/2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of SAE1/UBA2 in human HCT-116 cells assessed as reduction in Ubc9-SUMO level incubated for 24 hrs by immunoblot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetUbiquitin-like modifier-activating enzyme ATG7(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of His-tagged ATG7 (unknown origin) expressed in sf9 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNEDD8-conjugating enzyme Ubc12(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50311743(CHEMBL487992 | GARTANIN)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of Ubc12 (unknown origin)-neddylation incubated for 30 mins in presence of ATP by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed