Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50006656
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501645(CHEMBL4084281)
Affinity DataKd:  1.73E+4nMAssay Description:Binding affinity to human N-terminal 6His-tagged DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) after 150 secs by SPR-based bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501649(CHEMBL4083341)
Affinity DataIC50: 3.96E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) at preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501647(CHEMBL4074436)
Affinity DataIC50: 4.09E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) at preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501648(CHEMBL4068051)
Affinity DataIC50: 4.48E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) at preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501651(CHEMBL4102247)
Affinity DataIC50: 4.64E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) at preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501650(CHEMBL4092036)
Affinity DataIC50: 6.47E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) at preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501649(CHEMBL4083341)
Affinity DataIC50: 6.75E+3nMAssay Description:Inhibition of DOT1L in human MV4-11 cells assessed as reduction in cell viability after 72 hrs by alamar blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501651(CHEMBL4102247)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of DOT1L in human MV4-11 cells assessed as reduction in cell viability after 72 hrs by alamar blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501645(CHEMBL4084281)
Affinity DataIC50: 8.29E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) at preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM34422(3-(1-benzotriazolylmethyl)-6-(2,3-dihydro-1,4-benz...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) at preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501648(CHEMBL4068051)
Affinity DataIC50: 1.31E+4nMAssay Description:Inhibition of DOT1L in human MV4-11 cells assessed as reduction in cell viability after 72 hrs by alamar blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501646(CHEMBL4102657)
Affinity DataIC50: 1.74E+4nMAssay Description:Inhibition of N-terminal 6His-tagged human DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) at preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM34300(3-(benzotriazol-1-ylmethyl)-6-(phenylmethyl)-[1,2,...)
Affinity DataIC50: 1.94E+4nMAssay Description:Inhibition of N-terminal 6His-tagged human DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) at preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501645(CHEMBL4084281)
Affinity DataIC50: 2.19E+4nMAssay Description:Inhibition of DOT1L in human MV4-11 cells assessed as reduction in cell viability after 72 hrs by alamar blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501647(CHEMBL4074436)
Affinity DataIC50: 2.68E+4nMAssay Description:Inhibition of DOT1L in human MV4-11 cells assessed as reduction in cell viability after 72 hrs by alamar blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501645(CHEMBL4084281)
Affinity DataIC50: 2.81E+4nMAssay Description:Inhibition of DOT1L in human KOPN8 cells assessed as reduction in cell viability after 72 hrs by alamar blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM34422(3-(1-benzotriazolylmethyl)-6-(2,3-dihydro-1,4-benz...)
Affinity DataIC50: 4.07E+4nMAssay Description:Inhibition of DOT1L in human MV4-11 cells assessed as reduction in cell viability after 72 hrs by alamar blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM34300(3-(benzotriazol-1-ylmethyl)-6-(phenylmethyl)-[1,2,...)
Affinity DataIC50: 4.88E+4nMAssay Description:Inhibition of DOT1L in human MV4-11 cells assessed as reduction in cell viability after 72 hrs by alamar blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501645(CHEMBL4084281)
Affinity DataIC50: 5.58E+4nMAssay Description:Inhibition of DOT1L in human THP-1 cells assessed as reduction in cell viability after 72 hrs by alamar blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501646(CHEMBL4102657)
Affinity DataIC50: 6.40E+4nMAssay Description:Inhibition of DOT1L in human MV4-11 cells assessed as reduction in cell viability after 72 hrs by alamar blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501650(CHEMBL4092036)
Affinity DataIC50: 6.42E+4nMAssay Description:Inhibition of DOT1L in human MV4-11 cells assessed as reduction in cell viability after 72 hrs by alamar blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed