Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 50048989
TargetHigh affinity nerve growth factor receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50232542(CHEMBL4090531 | US10323022, Example 135)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of recombinant human TrkA expressed in DHFR deficient CHO cells assessed as inhibition of human beta-nerve growth factor-induced calcium i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of juxtamembrane region containing recombinant human N-terminal His6-tagged/GST-tagged TrkA (473 to 796 residues) expressed in baculovirus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity nerve growth factor receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50232542(CHEMBL4090531 | US10323022, Example 135)
Affinity DataIC50: 6nMAssay Description:Inhibition of juxtamembrane region containing recombinant human N-terminal His6-tagged/GST-tagged TrkA (473 to 796 residues) expressed in baculovirus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of recombinant human TrkB expressed in DHFR deficient CHO cells assessed as inhibition of human brain-derived neurotrophic factor-induced ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of recombinant human TrkC expressed in DHFR deficient CHO cells assessed as inhibition of human neurotrophin-3-induced calcium influx by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of juxtamembrane region deficient recombinant human N-terminal His6-tagged/GST-tagged TrkA (498 to 796 residues) expressed in baculovirus ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity nerve growth factor receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of recombinant human TrkA expressed in DHFR deficient CHO cells assessed as inhibition of human beta-nerve growth factor-induced calcium i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity nerve growth factor receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50022672(CHEMBL3298266)
Affinity DataIC50: 85nMAssay Description:Inhibition of juxtamembrane region containing recombinant human N-terminal His6-tagged/GST-tagged TrkA (473 to 796 residues) expressed in baculovirus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50022672(CHEMBL3298266)
Affinity DataIC50: 119nMAssay Description:Inhibition of juxtamembrane region containing recombinant human N-terminal His6-tagged/GST-tagged TrkA (473 to 796 residues) expressed in baculovirus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50022672(CHEMBL3298266)
Affinity DataIC50: 132nMAssay Description:Inhibition of recombinant human TrkB expressed in DHFR deficient CHO cells assessed as inhibition of human brain-derived neurotrophic factor-induced ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50022672(CHEMBL3298266)
Affinity DataIC50: 142nMAssay Description:Inhibition of recombinant human TrkC expressed in DHFR deficient CHO cells assessed as inhibition of human neurotrophin-3-induced calcium influx by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50022672(CHEMBL3298266)
Affinity DataIC50: 287nMAssay Description:Inhibition of juxtamembrane region deficient recombinant human N-terminal His6-tagged/GST-tagged TrkA (498 to 796 residues) expressed in baculovirus ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50232542(CHEMBL4090531 | US10323022, Example 135)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant human TrkB expressed in DHFR deficient CHO cells assessed as inhibition of human brain-derived neurotrophic factor-induced ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50232542(CHEMBL4090531 | US10323022, Example 135)
Affinity DataIC50: 2.48E+3nMAssay Description:Inhibition of recombinant human TrkC expressed in DHFR deficient CHO cells assessed as inhibition of human neurotrophin-3-induced calcium influx by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50232542(CHEMBL4090531 | US10323022, Example 135)
Affinity DataIC50: 3.72E+4nMAssay Description:Inhibition of juxtamembrane region deficient recombinant human N-terminal His6-tagged/GST-tagged TrkA (498 to 796 residues) expressed in baculovirus ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMed