Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50048986
TargetMetabotropic glutamate receptor 5(Human)
Institute For Advanced Chemistry of Catalonia (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50232462(ADX-10059 | Raseglurant)
Affinity DataIC50: 17nMAssay Description:Negative allosteric modulation of mGlu5 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Institute For Advanced Chemistry of Catalonia (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-phenylethynyl-pyridine | CHEMBL66654 | ...)
Affinity DataIC50: 36nMAssay Description:Negative allosteric modulation of recombinant human mGlu5a receptor assessed as inhibition of quisqualate-stimulated phosphoinositide hydrolysis by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Institute For Advanced Chemistry of Catalonia (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50179663(1-(3-chlorophenyl)-3-(1-methyl-5-oxoimidazolidin-2...)
Affinity DataIC50: 58nMAssay Description:Negative allosteric modulation of human mGlu5a receptor expressed in HEK293 cells co-expressing EAAC1 assessed as inhibition of quisqualate-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Institute For Advanced Chemistry of Catalonia (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50232458(CHEMBL4064885)
Affinity DataIC50: 430nMAssay Description:Negative allosteric modulation of rat N-terminal HA-tagged mGlu5 receptor expressed in HEK293 cells co-expressing N-terminal HA-tagged EAAC1 assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Institute For Advanced Chemistry of Catalonia (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50232463(CHEMBL4073483)
Affinity DataIC50: 960nMAssay Description:Negative allosteric modulation of rat N-terminal HA-tagged mGlu5 receptor expressed in HEK293 cells co-expressing N-terminal HA-tagged EAAC1 assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Institute For Advanced Chemistry of Catalonia (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50232459(CHEMBL4094126)
Affinity DataIC50: 1.21E+3nMAssay Description:Negative allosteric modulation of rat N-terminal HA-tagged mGlu5 receptor expressed in HEK293 cells co-expressing N-terminal HA-tagged EAAC1 assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Institute For Advanced Chemistry of Catalonia (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50179663(1-(3-chlorophenyl)-3-(1-methyl-5-oxoimidazolidin-2...)
Affinity DataIC50: 2.30E+3nMAssay Description:Negative allosteric modulation of rat N-terminal HA-tagged mGlu5 receptor expressed in HEK293 cells co-expressing N-terminal HA-tagged EAAC1 assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Institute For Advanced Chemistry of Catalonia (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50232460(CHEMBL4101860)
Affinity DataIC50: 3.09E+3nMAssay Description:Negative allosteric modulation of rat N-terminal HA-tagged mGlu5 receptor expressed in HEK293 cells co-expressing N-terminal HA-tagged EAAC1 assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Institute For Advanced Chemistry of Catalonia (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50232461(CHEMBL4083861)
Affinity DataIC50: 4.92E+3nMAssay Description:Negative allosteric modulation of rat N-terminal HA-tagged mGlu5 receptor expressed in HEK293 cells co-expressing N-terminal HA-tagged EAAC1 assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Institute For Advanced Chemistry of Catalonia (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50232472(CHEMBL4063852)
Affinity DataIC50: 6.13E+3nMAssay Description:Negative allosteric modulation of rat N-terminal HA-tagged mGlu5 receptor expressed in HEK293 cells co-expressing N-terminal HA-tagged EAAC1 assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details Article
PubMed