Compile Data Set for Download or QSAR
Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 50032358
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327662(11H-Dibenzo[b,e]azepine-3-carboxylic acid methyl e...)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327673(Dibenzo[b,f][1,4]oxazepine-6-carbonitrile | CHEMBL...)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50203072(Allylisothiocyanate | 3-isothiocyanatoprop-1-ene |...)
Affinity DataEC50:  1.20E+4nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at -30 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50203072(Allylisothiocyanate | 3-isothiocyanatoprop-1-ene |...)
Affinity DataEC50:  5.75E+3nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as time point of maximal current amplitude by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327656(Dibenzo[b,f][1,4]oxazepin-3-o | CHEMBL1256339)
Affinity DataEC50:  2.10nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327672(Dibenzo[b,f][1,4]oxazepine-4-carbonitrile | CHEMBL...)
Affinity DataEC50:  0.150nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50203072(Allylisothiocyanate | 3-isothiocyanatoprop-1-ene |...)
Affinity DataEC50:  2.24E+4nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at -75 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327668(8-Bromo-11H-dibenzo[b,e]azepine | CHEMBL1255819)
Affinity DataEC50:  33nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327674(11H-Dibenzo[b,e]azepine-10-carboxylic amide | CHEM...)
Affinity DataEC50:  2.5nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327663(11H-dibenzo[b,e]azepine-4-carboxylic acid methyl e...)
Affinity DataEC50:  31nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50240520(benzyl isothiocyanate | BITC, 17 | Isothiocyanic a...)
Affinity DataEC50:  1.10E+4nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as time point of maximal current amplitude by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327664(11H-Dibenzo[b,e]azepine-7-carboxylic acid methyl e...)
Affinity DataEC50:  31nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327670(11H-dibenzo[b,e]azepine-8-carbonitrile | CHEMBL125...)
Affinity DataEC50:  158nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50240520(benzyl isothiocyanate | BITC, 17 | Isothiocyanic a...)
Affinity DataEC50:  2.75E+4nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at -75 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318515(bromo benzyl cyanide | CHEMBL1085832)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327657(2-chlorobenzylidenemalononitrile | CHEMBL1256101)
Affinity DataEC50:  0.900nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327654(dibenzo[b,f][1,4]thiazepine | CHEMBL1256377)
Affinity DataEC50:  9nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM7873(2-chloro-1-phenylethan-1-one | CHEMBL105712 | Halo...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327669(10-Bromo-11H-dibenzo[b,e]azepine hydrochloride | C...)
Affinity DataEC50:  3.5nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50240520(benzyl isothiocyanate | BITC, 17 | Isothiocyanic a...)
Affinity DataEC50:  2.40E+4nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at 75 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327658(11H-Dibenzo[b,e]-azepine-10-carboxylic Acid Methyl...)
Affinity DataEC50:  38nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at -30 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327667(Dibenzo[b,f][1,4]oxazepine-4-carboxylic Acid Methy...)
Affinity DataEC50:  83.2nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at -30 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50240520(benzyl isothiocyanate | BITC, 17 | Isothiocyanic a...)
Affinity DataEC50:  1.55E+4nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at -30 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50203072(Allylisothiocyanate | 3-isothiocyanatoprop-1-ene |...)
Affinity DataEC50:  1.05E+4nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at 75 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327658(11H-Dibenzo[b,e]-azepine-10-carboxylic Acid Methyl...)
Affinity DataEC50:  72nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at -75 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327665(11H-dibenzo[b,e]azepine-8-carboxylic Acid MethylEs...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318511(dibenzo[b,f][1,4]oxazepine | CHEMBL1085100)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327659(11H-dibenzo[b,e]azepine | morphanthridine | CHEMBL...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327666(Dibenzo[b,f][1,4]oxazepine-3-carboxylic acid methy...)
Affinity DataEC50:  6nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327658(11H-Dibenzo[b,e]-azepine-10-carboxylic Acid Methyl...)
Affinity DataEC50:  38nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at -30 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327667(Dibenzo[b,f][1,4]oxazepine-4-carboxylic Acid Methy...)
Affinity DataEC50:  83nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at -30 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327658(11H-Dibenzo[b,e]-azepine-10-carboxylic Acid Methyl...)
Affinity DataEC50:  9.80nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at 75 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327667(Dibenzo[b,f][1,4]oxazepine-4-carboxylic Acid Methy...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at 75 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327679(11H-Dibenzo[b,e]azepine-10-carboxylic acid | CHEMB...)
Affinity DataEC50:  245nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50203072(Allylisothiocyanate | 3-isothiocyanatoprop-1-ene |...)
Affinity DataEC50:  398nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327680(11H-Dibenzo[b,e]azepine-10-carboxylic acid(3-metho...)
Affinity DataEC50:  7.70nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327677(11H-dibenzo[b,e]azepine-8-carboxylic acid isopropy...)
Affinity DataEC50:  933nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327667(Dibenzo[b,f][1,4]oxazepine-4-carboxylic Acid Methy...)
Affinity DataEC50:  126nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at -75 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327660(11H-Dibenzo[b,e]azepine-1-carboxylic acid methyl e...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327681(11H-Dibenzo[b,e]azepine-10-carboxylic acid diethyl...)
Affinity DataEC50:  40nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327658(11H-Dibenzo[b,e]-azepine-10-carboxylic Acid Methyl...)
Affinity DataEC50:  4.40nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as time point of maximal current amplitude by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327667(Dibenzo[b,f][1,4]oxazepine-4-carboxylic Acid Methy...)
Affinity DataEC50:  7.40nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as time point of maximal current amplitude by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327655(3-methoxydibenzo[b,f][1,4]oxazepine | CHEMBL125631...)
Affinity DataEC50:  14nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327661(11H-dibenzo[b,e]azepine-2-carboxylic acid methyl e...)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327676(Dibenzo[b,f][1,4]oxazepine-6-carboxylic acid amide...)
Affinity DataEC50:  0.110nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327678(CHEMBL1258323 | CHEMBL1084638 | 11H-dibenzo[b,e]az...)
Affinity DataEC50:  6.20nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327675(Dibenzo[b,f][1,4]oxazepine-4-carboxylic Acid Amide...)
Affinity DataEC50:  0.0800nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327671(11H-Dibenzo[b,e]azepine-10-carbonitrile hydrochlor...)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed