Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 2742
LigandPNGBDBM24019(1-benzyl-5-methyl-5'-(4-methylphenyl)-1,2-dihydro-...)
Affinity DataIC50: 610nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24008(CHEMBL401435 | 1-benzyl-5'-(4-methoxyphenyl)-5-met...)
Affinity DataIC50: 640nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24006(5'-(4-methoxyphenyl)-6-propyl-1,2-dihydro-3'H-spir...)
Affinity DataIC50: 780nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24007(1-benzyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
Affinity DataIC50: 870nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24009(5'-(4-methoxyphenyl)-5-methyl-1-(2-methylphenyl)-1...)
Affinity DataIC50: 900nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24022(1-benzyl-5'-(4-methoxyphenyl)-5-methyl-6-propyl-1,...)
Affinity DataIC50: 950nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24013(6-chloro-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
Affinity DataIC50: 1.20E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24018(5-methyl-1-(2-methylphenyl)-5'-(4-methylphenyl)-1,...)
Affinity DataIC50: 1.20E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24001(5'-(4-methylphenyl)-6-propyl-1,2-dihydro-3'H-spiro...)
Affinity DataIC50: 1.40E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24004(5-ethyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spiro...)
Affinity DataIC50: 1.40E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24012(5'-(4-methoxyphenyl)-6-methyl-1,2-dihydro-3'H-spir...)
Affinity DataIC50: 1.40E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24021(1-(4-chlorophenyl)-5'-(4-methoxyphenyl)-5-methyl-1...)
Affinity DataIC50: 1.50E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM24006(5'-(4-methoxyphenyl)-6-propyl-1,2-dihydro-3'H-spir...)
Affinity DataIC50: 1.70E+3nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24000(5-ethyl-5'-(4-methylphenyl)-1,2-dihydro-3'H-spiro[...)
Affinity DataIC50: 1.90E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24005(5-chloro-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
Affinity DataIC50: 2.00E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24010(5-bromo-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spiro...)
Affinity DataIC50: 2.40E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24003(5'-(4-methoxyphenyl)-5-methyl-1,2-dihydro-3'H-spir...)
Affinity DataIC50: 2.50E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24016(1,5'-diphenyl-1,2-dihydro-3'H-spiro[indole-3,2'-[1...)
Affinity DataIC50: 2.60E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM23999(5-methyl-5'-(4-methylphenyl)-1,2-dihydro-3'H-spiro...)
Affinity DataIC50: 3.00E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24015(5'-phenyl-1-(propan-2-yl)-1,2-dihydro-3'H-spiro[in...)
Affinity DataIC50: 3.10E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM23998(5'-(4-methylphenyl)-1,2-dihydro-3'H-spiro[indole-3...)
Affinity DataIC50: 3.70E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24011(5'-(4-methoxyphenyl)-5-nitro-1,2-dihydro-3'H-spiro...)
Affinity DataIC50: 4.40E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24017(1-methyl-5'-(4-methylphenyl)-1,2-dihydro-3'H-spiro...)
Affinity DataIC50: 4.60E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM24007(1-benzyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
Affinity DataIC50: 5.60E+3nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM23997(5'-phenyl-5-(trifluoromethoxy)-1,2-dihydro-3'H-spi...)
Affinity DataIC50: 7.20E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24020(5'-(4-methoxyphenyl)-1-methyl-1,2-dihydro-3'H-spir...)
Affinity DataIC50: 7.50E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM23996(5-ethyl-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,2...)
Affinity DataIC50: 9.60E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24009(5'-(4-methoxyphenyl)-5-methyl-1-(2-methylphenyl)-1...)
Affinity DataIC50: 1.05E+4nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM23995(5-methyl-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,...)
Affinity DataIC50: 1.11E+4nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24002(5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spiro[indole-...)
Affinity DataIC50: 1.34E+4nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM23994(5-bromo-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,2...)
Affinity DataIC50: 1.36E+4nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM24009(5'-(4-methoxyphenyl)-5-methyl-1-(2-methylphenyl)-1...)
Affinity DataIC50: 2.20E+4nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM24008(CHEMBL401435 | 1-benzyl-5'-(4-methoxyphenyl)-5-met...)
Affinity DataIC50: 2.20E+4nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM24006(5'-(4-methoxyphenyl)-6-propyl-1,2-dihydro-3'H-spir...)
Affinity DataIC50: 2.20E+4nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24008(CHEMBL401435 | 1-benzyl-5'-(4-methoxyphenyl)-5-met...)
Affinity DataIC50: 2.20E+4nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24007(1-benzyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
Affinity DataIC50: 2.20E+4nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24006(5'-(4-methoxyphenyl)-6-propyl-1,2-dihydro-3'H-spir...)
Affinity DataIC50: 2.20E+4nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM24014(1-methyl-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,...)
Affinity DataIC50: 2.41E+4nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
LigandPNGBDBM23992(5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,2'-[1,3,4...)
Affinity DataIC50: 2.42E+4nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM24009(5'-(4-methoxyphenyl)-5-methyl-1-(2-methylphenyl)-1...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM24008(CHEMBL401435 | 1-benzyl-5'-(4-methoxyphenyl)-5-met...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM24007(1-benzyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed