Compile Data Set for Download or QSAR
Report error Found 32 Enz. Inhib. hit(s) with all data for entry = 50017775
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-phenylethynyl-pyridine | CHEMBL66654 | ...)
Affinity DataIC50: 13nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-phenylethynyl-pyridine | CHEMBL66654 | ...)
Affinity DataIC50: 39nMAssay Description:Antagonist activity against mGluR5 expressed in CHO cells assessed as inhibition of agonist-induced phosphoinositide hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186330(3-cyano-N-(6-methylpyridin-2-yl)benzamide | CHEMBL...)
Affinity DataIC50: 330nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50122758(3-(2-(2-methylthiazol-4-yl)ethynyl)pyridine | 3-[(...)
Affinity DataIC50: 462nMAssay Description:Antagonist activity against mGluR5 expressed in CHO cells assessed as inhibition of agonist-induced phosphoinositide hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186324(3-bromo-N-(6-methylpyridin-2-yl)benzamide | CHEMBL...)
Affinity DataIC50: 650nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186325(3-iodo-N-(6-methylpyridin-2-yl)benzamide | CHEMBL2...)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50084141((E)-2-methyl-6-styrylpyridine | SIB-1757 | 2-Methy...)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186323(3-chloro-N-(6-methylpyridin-2-yl)benzamide | CHEMB...)
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM86717(CAS_5218788 | NSC_5218788 | CHEMBL88553 | SIB-1757)
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186322(3-chloro-N-(6-chloropyridin-2-yl)benzamide | CHEMB...)
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186319(3-methyl-N-(6-methylpyridin-2-yl)benzamide | CHEMB...)
Affinity DataIC50: 1.84E+3nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186330(3-cyano-N-(6-methylpyridin-2-yl)benzamide | CHEMBL...)
Affinity DataIC50: 5.33E+3nMAssay Description:Antagonist activity against mGluR5 expressed in CHO cells assessed as inhibition of agonist-induced phosphoinositide hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186324(3-bromo-N-(6-methylpyridin-2-yl)benzamide | CHEMBL...)
Affinity DataIC50: 5.48E+3nMAssay Description:Antagonist activity against mGluR5 expressed in CHO cells assessed as inhibition of agonist-induced phosphoinositide hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186320(3-chloro-N-(4-methylthiazol-2-yl)benzamide | CHEMB...)
Affinity DataIC50: 5.49E+3nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186319(3-methyl-N-(6-methylpyridin-2-yl)benzamide | CHEMB...)
Affinity DataIC50: 5.90E+3nMAssay Description:Antagonist activity against mGluR5 expressed in CHO cells assessed as inhibition of agonist-induced phosphoinositide hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186331(biphenyl-3-carboxylic acid (6-methyl-pyridin-2-yl)...)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186332(CHEMBL211740 | cid_2679292 | 3-methoxy-N-(4-methyl...)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186321(3-methoxy-N-(6-methylpyridin-2-yl)benzamide | CHEM...)
Affinity DataIC50: 9.76E+3nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186325(3-iodo-N-(6-methylpyridin-2-yl)benzamide | CHEMBL2...)
Affinity DataIC50: 1.08E+4nMAssay Description:Antagonist activity against mGluR5 expressed in CHO cells assessed as inhibition of agonist-induced phosphoinositide hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186322(3-chloro-N-(6-chloropyridin-2-yl)benzamide | CHEMB...)
Affinity DataIC50: 1.27E+4nMAssay Description:Antagonist activity against mGluR5 expressed in CHO cells assessed as inhibition of agonist-induced phosphoinositide hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186320(3-chloro-N-(4-methylthiazol-2-yl)benzamide | CHEMB...)
Affinity DataIC50: 1.50E+4nMAssay Description:Antagonist activity against mGluR5 expressed in CHO cells assessed as inhibition of agonist-induced phosphoinositide hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186331(biphenyl-3-carboxylic acid (6-methyl-pyridin-2-yl)...)
Affinity DataIC50: 1.83E+4nMAssay Description:Antagonist activity against mGluR5 expressed in CHO cells assessed as inhibition of agonist-induced phosphoinositide hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186327(N-(6-methylpyridin-2-yl)-3-(trifluoromethyl)benzam...)
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186334(N-(6-methylpyridin-2-yl)-3-phenethoxybenzamide | C...)
Affinity DataIC50: 2.36E+4nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186333(3-(benzyloxy)-N-(6-methylpyridin-2-yl)benzamide | ...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186336(N-(6-methylpyridin-2-yl)benzamide | CHEMBL209461)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186321(3-methoxy-N-(6-methylpyridin-2-yl)benzamide | CHEM...)
Affinity DataIC50: 4.60E+4nMAssay Description:Antagonist activity against mGluR5 expressed in CHO cells assessed as inhibition of agonist-induced phosphoinositide hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186337(N-(6-methylpyridin-2-yl)-3-phenoxybenzamide | CHEM...)
Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186326(N-(6-methylpyridin-2-yl)-1-naphthamide | CHEMBL210...)
Affinity DataIC50: 6.28E+4nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186335(N-(4-methylthiazol-2-yl)benzamide | CHEMBL209410)
Affinity DataIC50: 6.50E+4nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186328(3-((6-methylpyridin-2-yl)carbamoyl)phenyl methanes...)
Affinity DataIC50: 8.36E+4nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186329(N-(pyridin-2-yl)benzamide | N-Pyridin-2-yl-benzami...)
Affinity DataIC50: 9.54E+4nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed