Compile Data Set for Download or QSAR
Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 1889
TargetSerine/threonine-protein kinase Chk1(Human)
Vernalis (R&D)

LigandPNGBDBM14805(3-({5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}a...)
Affinity DataIC50: 1.40E+3nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14805(3-({5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}a...)
Affinity DataIC50: 1.50E+3nMpH: 7.5 T: 2°CAssay Description:Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Vernalis (R&D)

LigandPNGBDBM14803(2-({5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}a...)
Affinity DataIC50: 2.30E+3nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14804(1-({5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}a...)
Affinity DataIC50: 3.70E+3nMpH: 7.5 T: 2°CAssay Description:Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14803(2-({5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}a...)
Affinity DataIC50: 5.00E+3nMpH: 7.5 T: 2°CAssay Description:Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Vernalis (R&D)

LigandPNGBDBM14804(1-({5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}a...)
Affinity DataIC50: 5.50E+3nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Vernalis (R&D)

LigandPNGBDBM14801(2-({5,6-diphenylfuro[2,3-d]pyrimidin-4-yl}(methyl)...)
Affinity DataIC50: 6.10E+3nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Vernalis (R&D)

LigandPNGBDBM14799(2-{[5,6-bis(4-methoxyphenyl)furo[2,3-d]pyrimidin-4...)
Affinity DataIC50: 1.54E+4nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Vernalis (R&D)

LigandPNGBDBM14800(2-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-et...)
Affinity DataIC50: 2.09E+4nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Vernalis (R&D)

LigandPNGBDBM14802((5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-acet...)
Affinity DataIC50: 2.29E+4nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14799(2-{[5,6-bis(4-methoxyphenyl)furo[2,3-d]pyrimidin-4...)
Affinity DataIC50: 2.94E+4nMpH: 7.5 T: 2°CAssay Description:Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Vernalis (R&D)

LigandPNGBDBM14813(2-({5,6-diphenylfuro[2,3-d]pyrimidin-4-yl}amino)pr...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Vernalis (R&D)

LigandPNGBDBM14812((5,6-Diphenyl-furo[2,3-d]pyrimidin-4-yl)-(2-methox...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Vernalis (R&D)

LigandPNGBDBM14811(N-(2-aminoethyl)-5,6-diphenylfuro[2,3-d]pyrimidin-...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Vernalis (R&D)

LigandPNGBDBM14810(2-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-2-...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Vernalis (R&D)

LigandPNGBDBM14809(N-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-yl)-benzami...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Vernalis (R&D)

LigandPNGBDBM14808(N-benzyl-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine ...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Vernalis (R&D)

LigandPNGBDBM14807(DFP-4AP | 3-({5,6-diphenylfuro[2,3-d]pyrimidin-4-y...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Vernalis (R&D)

LigandPNGBDBM14806(DFP-4A | 5,6-diphenylfuro[2,3-d]pyrimidin-4-amine ...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14801(2-({5,6-diphenylfuro[2,3-d]pyrimidin-4-yl}(methyl)...)
Affinity DataIC50: 1.11E+5nMpH: 7.5 T: 2°CAssay Description:Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14800(2-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-et...)
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14802((5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-acet...)
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14799(2-{[5,6-bis(4-methoxyphenyl)furo[2,3-d]pyrimidin-4...)
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14800(2-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-et...)
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14801(2-({5,6-diphenylfuro[2,3-d]pyrimidin-4-yl}(methyl)...)
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14802((5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-acet...)
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14803(2-({5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}a...)
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14804(1-({5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}a...)
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14805(3-({5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}a...)
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed