Release Notes for 2026-04-26: Number of new affinity data: 3175 Number of compounds (ligands) new to BindingDB: 2426 Number of Targets new to BindingDB: 8 255 entries whose assays containing "cell based", "cell-based", or "cell_based" were removed from the databased; as a result, 9,285 affinity data are deleted. New Targets: Bifunctional farnesyl/geranylgeranyl diphosphate synthase (Q8II79): 13 inhibitors DNA repair protein XRCC1 (P09874): 15 inhibitors Dipeptidyl peptidase 7 (R4GN05): 1 inhibitors GTPase KRas [1-169,G12C] (P01116[1-169,G12C]): 81 inhibitors PRKR-interacting protein 1 (Q9H875): 8 inhibitors Poly(ADP-ribose) glycohydrolase [448-976,L473S,N479S,S802A,R811K,M841I,S858P,I916T,T924D,D927K,C963S,A967T] (Q86W56[448-976,L473S,N479S,S802A,R811K,M841I,S858P,I916T,T924D,D927K,C963S,A967T]): 1 inhibitors SH3 domain-binding glutamic acid-rich-like protein 3/Microtubule-associated protein tau/Tyrosine-protein kinase Fyn (Q9H299,P10636,P06241): 29 inhibitors Transient receptor potential cation channel subfamily M member 3 (J9SQF3): 887 inhibitors Number of new Entries: 41 PubMed id or Patent id Title US12209081 Heterocycle derivatives for treating TRPM3 mediated disorders US12478607 Compounds useful for inhibiting BFL1 and their use in therapy US12478616 PI3K inhibitors and uses thereof US12479800 Phenylpropionamide compound and use thereof US12479829 2-[2-methylazetidin-1-yl]-4-phenyl-6-(trifluoromethyl)-pyrimidine compounds US12479838 D3 receptor agonist compounds; methods of preparation; intermediates thereof; and methods of use thereof US12479839 Crystalline form of ATR inhibitor and use thereof US12479845 Imidazopyridine derivative compounds and use of same US12479866 Boron-containing rho kinase inhibitors US12479887 Inhibitors for protein n-terminal methyltransferase and uses thereof US12485157 Method of treating COVID-19 US12486251 CBP/EP300 inhibitor and use thereof US12486266 Crystalline form of JAK inhibitor and application thereof US12486270 Receptor tyrosine kinase inhibitors for treatment of protein kinase modulation-responsive disease or disorder US12486273 Hydro-1H-pyrrolo[1,2-a]pyrazine compounds for the treatment of autoimmune disease US12486274 Substituted pyrazolo-pyrimidines and uses thereof US12486280 CDK inhibitors and uses thereof US12491188 Small molecule PARG inhibitors and methods of use thereof US12492163 9H-fluorene derivatives or their pharmaceutically acceptable salts US12492186 Bicyclic heterocyclic compounds useful as IRAK4 inhibitors US12492199 Pyridopyrimidines as histamine H4-receptor inhibitors US12492202 Macrocyclic PAD4 inhibitors useful as immunosuppressant US12492204 Substituted (7H-pyrrolo[2,3-D]pyrimidin-4-yl) amino compounds useful as JAK 1 inhibitors US12492215 Pyrrolotriazine compounds acting as MNK inhibitor US20250360145 CSF-1R INHIBITORS AND USES THEREOF US20250361235 PIPERIDINYL-METHYLPURINE BENZENES AND RELATED COMPOUNDS AND THEIR USE IN TREATING DISEASES AND CONDITIONS US20250361240 PYRANOPYRIDINE COMPOUND, PROCESS FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITION AND USE THEREOF US20250361241 HPK1 INHIBITOR AND MEDICAL USE THEREOF US20250367209 IDENTIFICATION OF NOVEL BENZOTHIAZONES AS TAU-SH3 INTERACTION INHIBITORS FOR THE TREATMENT OF ALZHEIMER’S DISEASE US20250367283 MEVALONATE PATHWAY INHIBITOR AS HIGHLY-EFFICIENT VACCINE ADJUVANT US20250368608 SELECTIVE HDAC6 INHIBITOR US20250368616 NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF US20250368624 M24B AMINOPEPTIDASE INHIBITORS FOR CARD8 INFLAMMASOME ACTIVATION US20250368634 PHENYL AMIDE COMPOUNDS AND METHODS OF USE US20250368637 SOLID-STATE FORMS OF N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOETHYL)-6-MORPHOLINOQUINOLINE-4-CARBOXAMIDE US20250368640 MULTIPLE KINASE DEGRADERS, COMPOSITIONS COMPRISING THE DEGRADER, AND METHODS OF USING THE SAME US20250368647 NITROGEN CONTAINING CONDENSED 2,3-DIHYDROQUINAZOLINONE COMPOUNDS AS NAV1.8 INHIBITORS US20250368650 5-(4-FLUOROPHENYL)-2,3-DIHYDRO-1H-IMIDAZO[1,2-A]IMIDAZOLE DERIVATIVES AS ALK INHIBITORS FOR THE TREATMENT OF FIBROSIS US20250368667 USP1 INHIBITOR US20250376464 Compounds for treatment a coronavirus infection WO2024074497 PARG INHIBITORY COMPOUND