Release Notes for 2025-07-04: Number of new affinity data: 13034 Number of compounds (ligands) new to BindingDB: 7753 Number of Targets new to BindingDB: 30 New Targets: Cytochrome P450 4A2 (P20816): 3 inhibitors Cytochrome P450 4F1 (P33274): 4 inhibitors Diacylglycerol kinase epsilon (P52429): 88 inhibitors E3 ubiquitin-protein ligase CBL-B/(E3-independent) E2 ubiquitin-conjugating enzyme D2 (P62837,Q13191): 42 inhibitors Epidermal growth factor receptor (EGFR)(L858R)(T790M) (P00533[T790M,L858R]): 106 inhibitors Epidermal growth factor receptor [1-18,20-745,751-1210,T790M,C797S] (P00533[1-18,20-1210,C797S]): 98 inhibitors Epidermal growth factor receptor [1-18,20-745,751-1210,T790M] (P00533[1-18,20-745,751-1210,T790M]): 80 inhibitors Epidermal growth factor receptor [669-1210] (P00533[669-1210]): 165 inhibitors Histone deacetylase 6 [482-800] (Q9UBN7): 187 inhibitors Isocitrate dehydrogenase [NADP] cytoplasmic [R132H,S280F] (O75874[R132H,S280F]): 8 inhibitors Lipoprotein(a) /B receptor (P08519,Q0VD83): 7 inhibitors Mitogen-activated protein kinase 14/Eukaryotic translation initiation factor 4E-binding protein 1 (Q13541,Q16539): 506 inhibitors Mitogen-activated protein kinase 14/Mitogen-activated protein kinase 1 (P28482,Q16539): 511 inhibitors Nuclear receptor ROR-gamma [C278S] (P51449[C278S]): 2 inhibitors Nuclear receptor ROR-gamma [C285S] (P51449[C285S]): 2 inhibitors Nuclear receptor ROR-gamma [C320A] (P51449[C320A]): 2 inhibitors Nuclear receptor ROR-gamma [C320S] (P51449[C320S]): 2 inhibitors Nuclear receptor ROR-gamma [C345S] (P51449[C345S]): 2 inhibitors Nuclear receptor ROR-gamma [C366S] (P51449[C366S]): 2 inhibitors Nuclear receptor ROR-gamma [C393S] (P51449[C393S]): 2 inhibitors Nuclear receptor ROR-gamma [C455S] (P51449[C455S]): 2 inhibitors Peroxidase C1A/Choline Oxidase (P16101,P00433): 118 inhibitors Poly(ADP-ribose) glycohydrolase [389-976] (Q86W56[389-976]): 85 inhibitors Proto-oncogene tyrosine-protein kinase receptor Ret/Coiled-coil domain-containing protein 6 (P07949,Q16204): 7 inhibitors Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (Q15738): 5 inhibitors Tau-tubulin kinase 2 [1-450] (Q6IQ55[1-450]): 24 inhibitors Transcriptional enhancer factor TEF-1 [209-426] (P28347[209-426]): 10 inhibitors Tyrosine-protein kinase JAK2 [536-812,V617F] (O60674[536-812,V617F]): 12 inhibitors Tyrosine-protein kinase JAK2 [536-812] (O60674[536-812]): 39 inhibitors Number of new Entries: 103 PubMed id or Patent id Title US12208088 Spirocyclic 2,3-dihydro-7-azaindole compounds and uses thereof US12209074 SHP2 phosphatase allosteric inhibitor US12209075 Pyridine-sulfonamide derivatives as sodium channel inhibitors US12209085 RET inhibitors, pharmaceutical compositions and uses thereof US12215095 Compounds for the treatment of respiratory diseases US12215098 Solid form, crystalline form, and crystal form a of FXR agonist, and preparation method and application thereof US12215173 Kappa opioid receptor peptide amide ligands US12220415 WEE1 kinase inhibitors and methods of treating cancer using the same US12220419 BCL-2 inhibitors US12221426 Inhibitory material against human body-derived nicotinamide adenine dinucleotide phosphate-dependent steroid dehydrogenase-like, and anticancer agent comprising same as effective ingredient or pharmaceutical composition comprising same as effective ingredient for treatment of hyperlipidemia US12221439 Tetrahydropyridopyrimidine derivatives as AhR modulators US12221449 Pyrrolopyrimidine derivative and use thereof US12221453 Substituted pyrazolo[5′,1′:2,3]pyrimido[5,4-b][1,4]oxazines as TYK2 inhibitors US12226405 Compounds and compositions for inhibiting the activity of HIF2-alpha and their methods of use US12226414 1-isopropyl-3-methyl-8-(pyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c] cinnolin-2-one as selective modulators of ataxia telangiectasia mutated (ATM) kinase and uses thereof US12226418 Dosing regimen for the treatment of PI3K related disorders US12227501 3-amino-2-[2-(acylamino)pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one as CSNK1 inhibitors US12227502 1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c] pyridin-7(6H)-ones as inhibitors of BET proteins US12227509 Dihydropyrazolopyrazinone derivative having MGAT2 inhibitory activity US12227515 In-flow photooxygenation of aminothienopyridinones generates novel PTP4A3 phosphatase inhibitors US12227517 Pyridazinyl-thiazolecarboxamide compound US12234202 Covalent inhibitors of coronavirus papain-like protease US12234222 Piperazine amide derivative, preparation method therefor, and use thereof in medicine US12234230 Substituted benzyl-triazole compounds for Cbl-b inhibition, and further uses thereof US20250032476 ALPHA-2A ADRENERGIC RECEPTOR MODULATORS AND USES THEREOF US20250032489 MIXED LINEAGE KINASE INHIBITORS AND METHODS OF USE US20250032527 MEDICAL USE OF N4-HYDROXY CITICOLINE COMPOUNDS US20250032625 HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS US20250034106 3-CYCLOAMINO-INDOLE COMPOUNDS AS SEROTONERGIC AGENTS USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO US20250034108 SODIUM CHANNEL BLOCKERS US20250034112 IMPROVED SELECTIVE JAK2 INHIBITORS AND METHODS OF USE US20250034116 1,4-DIHETEROCYCLIC SUBSTITUTED AROMATIC RING OR AROMATIC HETEROCYCLIC COMPOUND AND USE THEREOF US20250034117 Deuterated 1,3 Dihydro -2H-indole-2-one derivatives US20250034122 SUBSTITUTED N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS US20250034134 15-PGDH INHIBITOR AND USE THEREOF US20250034135 ANTI-APOPTOTIC PROTEIN BCL-2 INHIBITOR, PHARMACEUTICAL COMPOSITION AND USES THEREOF US20250034136 WRN INHIBITORS US20250034153 TRIAZOLOPYRIMIDINES AS A2A / A2B INHIBITORS US20250034159 INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR US20250034165 COMPOUND CONTAINING CYCLOALKYL OR HALOALKYL US20250034168 NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE PARP INHIBITOR AND USE THEREOF US20250034169 NOVEL PYRIMIDOPYRIDINE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF US20250034173 PYRIDO[4,3-D]PYRIMIDINE COMPOUNDS US20250041279 THERAPEUTIC MEDICINE FOR HEART DISEASE OR SKELETAL MUSCLE DISEASE US20250041310 Combination Therapy Comprising A2A/A2B and PD-1/PD-L1 Inhibitors US20250042847 SUBSTITUTED PHENYLPROPIONIC ACID DERIVATIVE AND USE THEREOF US20250042850 PHARMACEUTICAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME US20250042853 BICYCLIC COMPOUND AND APPLICATION THEREOF US20250042857 SOS1 Inhibitor With Pyrido-Fused Six-Membered Ring Structure US20250042862 AROMATIC HETEROCYCLIC COMPOUND AND APPLICATION THEREOF US20250042884 3-ARYLOXYL-3-FIVE-MEMBERED HETEROARYL PROPYLAMINE COMPOUND AND USE THEREOF US20250042889 3CLPRO PROTEASE INHIBITOR US20250042890 METHIONINE ADENOSYLTRANSFERASE 2a (MAT2A) INHIBITORS AND USES THEREOF US20250042891 Compound containing structure of a heteroaromatic ring, pharmaceutical composition thereof and application thereof US20250042896 POLYCYCLIC COMPOUND AS CBL-B INHIBITOR US20250042898 Pharmaceutical Compounds And Compositions As c-Kit Kinase Inhibitors US20250042903 TRIAZINE INHIBITORS OF CYCLIN-DEPENDENT KINASES US20250042904 COMPOUNDS USED AS SRC INHIBITORS US20250042914 PIKFYVE KINASE INHIBITOR US20250042919 TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF US20250049736 SULFONAMIDE DERIVATIVES AND THEIR USE AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS US20250049765 BICYCLO [3.2.0] HEPTANE BIS(AMIDE) RXFP1 AGONISTS US20250049777 PHARMACEUTICALLY ACCEPTABLE SALT AND CRYSTALLINE FORM OF GLP-1 RECEPTOR AGONIST AND PREPARATION METHOD THEREFOR US20250049780 THIENOPYRROLE COMPOUNDS US20250049786 DOPAMINE D3/D2 RECEPTOR MODULATING COMPOUNDS US20250049809 INHIBITORS OF MUTANT IDH1 AND IDH2 US20250049817 JAK INHIBITOR WITH A VITAMIN D ANALOG FOR TREATMENT OF SKIN DISEASES US20250049967 PET TRACERS FOR VISUALIZING GABAA GAMMA1 RECEPTORS US20250051275 PYRROLE DERIVATIVE OR PHARMACEUTICALLY OR SITOLOGICALLY ACCEPTABLE SALTS THEREOF, AND COMPOSITION FOR PREVENTION, AMELIORATION OR TREATMENT OF GASTROINTESTINAL DISORDERS COMPRISING SAME AS ACTIVE INGREDIENT US20250051277 DELIVERY OF THERAPEUTIC ALKALOID COMPOUNDS US20250051303 SUBSTITUTED OXOPYRIDINE DERIVATIVES FOR THE TREATMENT AND/OR PROPHYLAXIS OF THROMBOTIC OR THROMBOEMBOLIC DISORDERS AND/OR THROMBOTIC OR THROMBOEMBOLIC COMPLICATIONS US20250051307 SALT OF 3,4-DIHYDROISOQUINOLINE COMPOUND AND USE THEREOF US20250051309 MK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME US20250051313 PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS US20250051319 COMPOUNDS AND USE THEREOF AS HDAC6 INHIBITORS US20250051321 TRICYCLIC DERIVATIVE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF US20250051323 BICYCLIC AMINE DERIVATIVES AS GABAA alpha5 RECEPTOR MODULATORS US20250051324 PARP INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF US20250051327 MALT-1 MODULATORS US20250051330 HETEROCYCLIC COMPOUND HAVING ANTI-TUMOR ACTIVITY AND USE THEREOF US20250051335 TAU-TUBULIN KINASE (TTBK) INHIBITOR COMPOUNDS US20250051337 INHIBITORS OF SERINE/THREONINE PROTEIN KINASE STK3 OR STK4 AND USES THEREOF US20250051345 PYRIDINE-3-CARBOXYLATE COMPOUNDS AS CAV1.2 ACTIVATORS US20250051362 SUBSTITUTED FUSED HETEROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF US20250051363 Substituted Pyrazolopyridines US20250051367 HETEROCYCLE-CONTAINING LONP1 INHIBITOR COMPOUNDS, USES AND METHODS US20250051375 ANTI-HIV COMPOUNDS US20250057848 GAL475 COMPOSITIONS AND METHODS OF USE THEREOF US20250059154 CYSTEINE-DEPENDENT INVERSE AGONISTS OF NUCLEAR RECEPTORS ROR-GAMMA/ROR-GAMMA-T AND METHODS OF TREATING DISEASES OR DISORDERS THEREWITH US20250059156 THERAPEUTIC ALKALOID COMPOUNDS US20250059159 PLPRO INHIBITORS US20250059172 INDAZOLE COMPOUND AND PHARMACEUTICAL US20250059174 Pharmaceutical Compounds and Compositions as C-Kit Kinase Inhibitors US20250059185 BICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS MONOACYLGLYCEROL LIPASE INHIBITORS US20250059186 Tricyclic Fused Heterocyclic PDE3/4 Dual Inhibitor and Use Thereof US20250059188 ARYLSULPHONAMIDE COMPOUNDS US20250059194 ULK1 AND ULK2 INHIBITORS US20250059196 TRICYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF US20250059204 FUSED BENZOISOXAZOLYL COMPOUNDS AS KAT6A INHIBITORS US20250059213 LONP1 INHIBITORS, USES AND METHODS US20250059214 AMIDE-CONTAINING LONP1 INHIBITOR COMPOUNDS, USES AND METHODS US20250059218 ENPP1 Inhibitors and Methods of Modulating Immune Response US20250059220 SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AND METHODS OF USE THEREOF