BDBM50432515 CHEMBL2349464

SMILES CC1(C)Cc2ccc(cc2C2(COC(N)=N2)C1)-c1cncc(F)c1

InChI Key InChIKey=GVUGSHHDPCGBJP-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50432515   

TargetBeta-secretase 1(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50432515(CHEMBL2349464)
Affinity DataEC50:  220nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing wild type APP assessed as level of amyloid beta (1 to 40) after 48 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50432515(CHEMBL2349464)
Affinity DataIC50: 5.84E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells using biotin-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCathepsin D(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50432515(CHEMBL2349464)
Affinity DataIC50: 4.86E+4nMAssay Description:Inhibition of human spleen cathepsin D using 5-FAM/QXL as peptide substrate after 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed