BDBM478989 (R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrolidine-1-carbonyl)-2- methylphenyl)acrylamide::US10894788, Example 29::US11390618, Example 29

SMILES Cc1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1

InChI Key InChIKey=MATPVGHWQGMDHM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 478989   

TargetCyclin-dependent kinase 12(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM478989((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Affinity DataIC50: 550nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM478989((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Affinity DataIC50: 100nMAssay Description:For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM478989((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Affinity DataIC50: 550nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM478989((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent